Developmental nonlinearity drives phenotypic robustness
Developmental processes often involve nonlinearities, but the consequences for translating genotype to phenotype are not well characterized. Here, Green et al. vary Fgf8 signaling across allelic series of mice and show that phenotypic robustness in craniofacial shape is explained by a nonlinear effe...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-02037-7 |
| _version_ | 1818749151124389888 |
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| author | Rebecca M. Green Jennifer L. Fish Nathan M. Young Francis J. Smith Benjamin Roberts Katie Dolan Irene Choi Courtney L. Leach Paul Gordon James M. Cheverud Charles C. Roseman Trevor J. Williams Ralph S. Marcucio Benedikt Hallgrímsson |
| author_facet | Rebecca M. Green Jennifer L. Fish Nathan M. Young Francis J. Smith Benjamin Roberts Katie Dolan Irene Choi Courtney L. Leach Paul Gordon James M. Cheverud Charles C. Roseman Trevor J. Williams Ralph S. Marcucio Benedikt Hallgrímsson |
| author_sort | Rebecca M. Green |
| collection | DOAJ |
| description | Developmental processes often involve nonlinearities, but the consequences for translating genotype to phenotype are not well characterized. Here, Green et al. vary Fgf8 signaling across allelic series of mice and show that phenotypic robustness in craniofacial shape is explained by a nonlinear effect of Fgf8 expression. |
| first_indexed | 2024-12-18T03:59:13Z |
| format | Article |
| id | doaj.art-4cead5cb41ca4d3196d3cbf94d5c65c2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T03:59:13Z |
| publishDate | 2017-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4cead5cb41ca4d3196d3cbf94d5c65c22022-12-21T21:21:43ZengNature PortfolioNature Communications2041-17232017-12-018111210.1038/s41467-017-02037-7Developmental nonlinearity drives phenotypic robustnessRebecca M. Green0Jennifer L. Fish1Nathan M. Young2Francis J. Smith3Benjamin Roberts4Katie Dolan5Irene Choi6Courtney L. Leach7Paul Gordon8James M. Cheverud9Charles C. Roseman10Trevor J. Williams11Ralph S. Marcucio12Benedikt Hallgrímsson13Department of Cell Biology & Anatomy, Alberta Children’s Hospital Research Institute and McCaig Bone and Joint Institute, Cumming School of Medicine, University of CalgaryDepartment of Biological Sciences, University of Massachusetts LowellDepartment of Orthopaedic Surgery, School of Medicine, University of California San FranciscoDepartment of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical CampusDepartment of Biological Sciences, University of Massachusetts LowellDepartment of Biological Sciences, University of Massachusetts LowellDepartment of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical CampusDepartment of Cell Biology & Anatomy, Alberta Children’s Hospital Research Institute and McCaig Bone and Joint Institute, Cumming School of Medicine, University of CalgaryAlberta Children’s Hospital Research Institute, Cumming School of Medicine, University of CalgaryDepartment of Biology, Loyola University ChicagoDepartment of Animal Biology, University of Illinois Urbana ChampaignDepartment of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical CampusDepartment of Orthopaedic Surgery, School of Medicine, University of California San FranciscoDepartment of Cell Biology & Anatomy, Alberta Children’s Hospital Research Institute and McCaig Bone and Joint Institute, Cumming School of Medicine, University of CalgaryDevelopmental processes often involve nonlinearities, but the consequences for translating genotype to phenotype are not well characterized. Here, Green et al. vary Fgf8 signaling across allelic series of mice and show that phenotypic robustness in craniofacial shape is explained by a nonlinear effect of Fgf8 expression.https://doi.org/10.1038/s41467-017-02037-7 |
| spellingShingle | Rebecca M. Green Jennifer L. Fish Nathan M. Young Francis J. Smith Benjamin Roberts Katie Dolan Irene Choi Courtney L. Leach Paul Gordon James M. Cheverud Charles C. Roseman Trevor J. Williams Ralph S. Marcucio Benedikt Hallgrímsson Developmental nonlinearity drives phenotypic robustness Nature Communications |
| title | Developmental nonlinearity drives phenotypic robustness |
| title_full | Developmental nonlinearity drives phenotypic robustness |
| title_fullStr | Developmental nonlinearity drives phenotypic robustness |
| title_full_unstemmed | Developmental nonlinearity drives phenotypic robustness |
| title_short | Developmental nonlinearity drives phenotypic robustness |
| title_sort | developmental nonlinearity drives phenotypic robustness |
| url | https://doi.org/10.1038/s41467-017-02037-7 |
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