Genistein Suppresses IL-6 and MMP-13 to Attenuate Osteoarthritis in Obese Diabetic Mice

Genistein Suppresses IL-6 and MMP-13 to Attenuate Osteoarthritis in Obese Diabetic Mice

Type 2 diabetes mellitus and osteoarthritis (OA) often present as comorbidities. We examined the role of plasma IL-6, chondrocyte MMP-13, and col10a expression in the development of OA in obese diabetic mice. We further investigated dietary genistein and exercise training as potential mitigators of...

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Bibliographic Details
Main Authors: Janelle Lopez, Layla Al-Nakkash, Tom L. Broderick, Monica Castro, Brielle Tobin, Jeffrey H. Plochocki
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Metabolites
Subjects:
obesity
type 2 diabetes
osteoarthritis
genistein
exercise
Online Access:https://www.mdpi.com/2218-1989/13/9/1014

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