Changes of Structural and Functional Attention Control Networks in Subclinical Hypothyroidism
Objective: This study aimed to explore the structural changes in patients with subclinical hypothyroidism (SCH) using voxel-based morphometry (VBM) and to investigate the altered attentional control networks using functional MRI (fMRI) during the performance of a modified Stroop task with Chinese ch...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-10-01
|
| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnbeh.2021.725908/full |
| _version_ | 1819005297608359936 |
|---|---|
| author | Jingjing Yin Jingjing Yin Jingjing Yin Lei Xie Lei Xie Lei Xie DongXue Luo Jinzhuang Huang Jinzhuang Huang Jinzhuang Huang Ruiwei Guo Ruiwei Guo Ruiwei Guo Yanmin Zheng Yanmin Zheng Yanmin Zheng Wencan Xu Shouxing Duan Shouxing Duan Zhirong Lin Shuhua Ma Shuhua Ma Shuhua Ma |
| author_facet | Jingjing Yin Jingjing Yin Jingjing Yin Lei Xie Lei Xie Lei Xie DongXue Luo Jinzhuang Huang Jinzhuang Huang Jinzhuang Huang Ruiwei Guo Ruiwei Guo Ruiwei Guo Yanmin Zheng Yanmin Zheng Yanmin Zheng Wencan Xu Shouxing Duan Shouxing Duan Zhirong Lin Shuhua Ma Shuhua Ma Shuhua Ma |
| author_sort | Jingjing Yin |
| collection | DOAJ |
| description | Objective: This study aimed to explore the structural changes in patients with subclinical hypothyroidism (SCH) using voxel-based morphometry (VBM) and to investigate the altered attentional control networks using functional MRI (fMRI) during the performance of a modified Stroop task with Chinese characters.Methods: High-resolution three-dimensional (3D) T1-weighted images and an fMRI scan were taken from 18 patients with SCH and 18 matched control subjects. The Montreal Cognitive Assessment Chinese-revised (MoCA-CR) and the Stroop task were used to evaluate the cognitive and attention control of the participants.Results: Compared to controls, the VBM results showed decreased gray matter volumes (GMVs) in bilateral prefrontal cortices (PFCs, including middle, medial, and inferior frontal gyri), cingulate gyrus, precuneus, left middle temporal gyrus, and insula in patients with SCH. The fMRI results showed a distributed network of brain regions in both groups, consisting of PFCs (including superior and middle and inferior frontal cortices), anterior cingulate cortex (ACC), posterior cingulate cortex, and precuneus, as well as the insula and caudate nucleus. Compared to controls, the SCH group had lower activation of the above brain areas, especially during the color-naming task. In addition, the normalized GMV (nGMV) was negatively correlated with thyroid-stimulating hormone (TSH) level (r = −0.722, p < 0.001).Conclusion: Results indicate that patients with SCH exhibit reduced GMVs, altered BOLD signals, and activation in regions associated with attention control, which further suggest that patients with SCH may have attentional control deficiency, and the weakened PFC–ACC–precuneus brain network might be one of the neural mechanisms. Negative correlations between nGMV and TSH suggest that TSH elevation may induce abnormalities in the cortex. |
| first_indexed | 2024-12-20T23:50:33Z |
| format | Article |
| id | doaj.art-4cebc418a3e64e9692bad721178d299b |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-20T23:50:33Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-4cebc418a3e64e9692bad721178d299b2022-12-21T19:22:50ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532021-10-011510.3389/fnbeh.2021.725908725908Changes of Structural and Functional Attention Control Networks in Subclinical HypothyroidismJingjing Yin0Jingjing Yin1Jingjing Yin2Lei Xie3Lei Xie4Lei Xie5DongXue Luo6Jinzhuang Huang7Jinzhuang Huang8Jinzhuang Huang9Ruiwei Guo10Ruiwei Guo11Ruiwei Guo12Yanmin Zheng13Yanmin Zheng14Yanmin Zheng15Wencan Xu16Shouxing Duan17Shouxing Duan18Zhirong Lin19Shuhua Ma20Shuhua Ma21Shuhua Ma22Department of Radiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Medical Imaging and Nuclear Medicine, Shantou University Medical College, Shantou, ChinaLaboratory of Medical Molecular Imaging, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Radiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Medical Imaging and Nuclear Medicine, Shantou University Medical College, Shantou, ChinaLaboratory of Medical Molecular Imaging, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Nuclear Medicine, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Radiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Medical Imaging and Nuclear Medicine, Shantou University Medical College, Shantou, ChinaLaboratory of Medical Molecular Imaging, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Radiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Medical Imaging and Nuclear Medicine, Shantou University Medical College, Shantou, ChinaLaboratory of Medical Molecular Imaging, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Radiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Medical Imaging and Nuclear Medicine, Shantou University Medical College, Shantou, ChinaLaboratory of Medical Molecular Imaging, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaLaboratory of Medical Molecular Imaging, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Pediatric Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Radiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Radiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Medical Imaging and Nuclear Medicine, Shantou University Medical College, Shantou, ChinaLaboratory of Medical Molecular Imaging, The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaObjective: This study aimed to explore the structural changes in patients with subclinical hypothyroidism (SCH) using voxel-based morphometry (VBM) and to investigate the altered attentional control networks using functional MRI (fMRI) during the performance of a modified Stroop task with Chinese characters.Methods: High-resolution three-dimensional (3D) T1-weighted images and an fMRI scan were taken from 18 patients with SCH and 18 matched control subjects. The Montreal Cognitive Assessment Chinese-revised (MoCA-CR) and the Stroop task were used to evaluate the cognitive and attention control of the participants.Results: Compared to controls, the VBM results showed decreased gray matter volumes (GMVs) in bilateral prefrontal cortices (PFCs, including middle, medial, and inferior frontal gyri), cingulate gyrus, precuneus, left middle temporal gyrus, and insula in patients with SCH. The fMRI results showed a distributed network of brain regions in both groups, consisting of PFCs (including superior and middle and inferior frontal cortices), anterior cingulate cortex (ACC), posterior cingulate cortex, and precuneus, as well as the insula and caudate nucleus. Compared to controls, the SCH group had lower activation of the above brain areas, especially during the color-naming task. In addition, the normalized GMV (nGMV) was negatively correlated with thyroid-stimulating hormone (TSH) level (r = −0.722, p < 0.001).Conclusion: Results indicate that patients with SCH exhibit reduced GMVs, altered BOLD signals, and activation in regions associated with attention control, which further suggest that patients with SCH may have attentional control deficiency, and the weakened PFC–ACC–precuneus brain network might be one of the neural mechanisms. Negative correlations between nGMV and TSH suggest that TSH elevation may induce abnormalities in the cortex.https://www.frontiersin.org/articles/10.3389/fnbeh.2021.725908/fullsubclinical hypothyroidismattentionvoxel-based morphometryfunctional magnetic resonance imagingbrain function |
| spellingShingle | Jingjing Yin Jingjing Yin Jingjing Yin Lei Xie Lei Xie Lei Xie DongXue Luo Jinzhuang Huang Jinzhuang Huang Jinzhuang Huang Ruiwei Guo Ruiwei Guo Ruiwei Guo Yanmin Zheng Yanmin Zheng Yanmin Zheng Wencan Xu Shouxing Duan Shouxing Duan Zhirong Lin Shuhua Ma Shuhua Ma Shuhua Ma Changes of Structural and Functional Attention Control Networks in Subclinical Hypothyroidism Frontiers in Behavioral Neuroscience subclinical hypothyroidism attention voxel-based morphometry functional magnetic resonance imaging brain function |
| title | Changes of Structural and Functional Attention Control Networks in Subclinical Hypothyroidism |
| title_full | Changes of Structural and Functional Attention Control Networks in Subclinical Hypothyroidism |
| title_fullStr | Changes of Structural and Functional Attention Control Networks in Subclinical Hypothyroidism |
| title_full_unstemmed | Changes of Structural and Functional Attention Control Networks in Subclinical Hypothyroidism |
| title_short | Changes of Structural and Functional Attention Control Networks in Subclinical Hypothyroidism |
| title_sort | changes of structural and functional attention control networks in subclinical hypothyroidism |
| topic | subclinical hypothyroidism attention voxel-based morphometry functional magnetic resonance imaging brain function |
| url | https://www.frontiersin.org/articles/10.3389/fnbeh.2021.725908/full |
| work_keys_str_mv | AT jingjingyin changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT jingjingyin changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT jingjingyin changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT leixie changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT leixie changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT leixie changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT dongxueluo changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT jinzhuanghuang changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT jinzhuanghuang changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT jinzhuanghuang changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT ruiweiguo changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT ruiweiguo changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT ruiweiguo changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT yanminzheng changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT yanminzheng changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT yanminzheng changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT wencanxu changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT shouxingduan changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT shouxingduan changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT zhironglin changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT shuhuama changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT shuhuama changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism AT shuhuama changesofstructuralandfunctionalattentioncontrolnetworksinsubclinicalhypothyroidism |