Polymorphous Low Grade Adenocarcinoma of the Parotid Gland. Cytological, Histological and Immunohistochemical Features and Review of the Literature
Aim: Polymorphous low grade adenocarcinoma of the salivary glands (PLGA) is a low grade neoplasm that predominantly occurs in the minor salivary glands. In this site is amenable to biopsy and histologic diagnosis. However, experience with cytological findings in these tumors is limited. We describe...
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| Format: | Article |
| Language: | English |
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Karolinum Press
2004-01-01
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| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/online_first/18059694.2018.57/ |
| _version_ | 1818548441834323968 |
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| author | Demetrio Tamiolakis Vasilios Thomaidis Ioannis Tsamis Eleni Kariki Athanasia Kotini Maria Lambropoulou Panagiotis Boglou Nikolaos Papadopoulos |
| author_facet | Demetrio Tamiolakis Vasilios Thomaidis Ioannis Tsamis Eleni Kariki Athanasia Kotini Maria Lambropoulou Panagiotis Boglou Nikolaos Papadopoulos |
| author_sort | Demetrio Tamiolakis |
| collection | DOAJ |
| description | Aim: Polymorphous low grade adenocarcinoma of the salivary glands (PLGA) is a low grade neoplasm that predominantly occurs in the minor salivary glands. In this site is amenable to biopsy and histologic diagnosis. However, experience with cytological findings in these tumors is limited. We describe the cytology of this entity. Experimental design: Touch imprint cytology of a primary parotid PLGA is specified and correlated with histology. Results: Smears were hypercellular showing branching papillae, sheets and clusters of uniform cells with bland nuclei, dispersed chromatin and no nucleoli. The cells had a scant to moderate amount of eosinophilic cytoplasm. They formed tubular structures containing hyaline globules. Conclusions. The cytologic differential diagnosis of PLGA includes adenoid cystic carcinoma, pleomorphic adenoma, and monomorphic adenoma. PLGA should be considered in the differential diagnosis of head and neck tumors, where the cytology suggests on of the above mentioned tumors, even when the clinical findings (involvement of a major salivary gland, lymph node metastasis) is not typical of PLGA. |
| first_indexed | 2024-12-12T08:19:57Z |
| format | Article |
| id | doaj.art-4ced31bb09884634b7c4ab3c6291e0c4 |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-12-12T08:19:57Z |
| publishDate | 2004-01-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-4ced31bb09884634b7c4ab3c6291e0c42022-12-22T00:31:25ZengKarolinum PressActa Medica1211-42861805-96942004-01-014713610.14712/18059694.2018.57Polymorphous Low Grade Adenocarcinoma of the Parotid Gland. Cytological, Histological and Immunohistochemical Features and Review of the LiteratureDemetrio Tamiolakis0Vasilios Thomaidis1Ioannis Tsamis2Eleni Kariki3Athanasia Kotini4Maria Lambropoulou5Panagiotis Boglou6Nikolaos Papadopoulos7General Hospital of Alexandroupolis, Department of Cytology, GreeceGeneral Hospital of Alexandroupolis, Department of Maxillofacial Surgery, GreeceGeneral Hospital of Alexandroupolis, Department of Maxillofacial Surgery, GreecePapanicolaou Hospital of Salonica, Department of Pathology, GreeceDemocritus University of Thrace, Department of Medical Physics, GreeceDemocritus University of Thrace, Department of Histology – Embryology, GreeceDemocritus University of Thrace, Department of Histology – Embryology, GreeceDemocritus University of Thrace, Department of Histology – Embryology, GreeceAim: Polymorphous low grade adenocarcinoma of the salivary glands (PLGA) is a low grade neoplasm that predominantly occurs in the minor salivary glands. In this site is amenable to biopsy and histologic diagnosis. However, experience with cytological findings in these tumors is limited. We describe the cytology of this entity. Experimental design: Touch imprint cytology of a primary parotid PLGA is specified and correlated with histology. Results: Smears were hypercellular showing branching papillae, sheets and clusters of uniform cells with bland nuclei, dispersed chromatin and no nucleoli. The cells had a scant to moderate amount of eosinophilic cytoplasm. They formed tubular structures containing hyaline globules. Conclusions. The cytologic differential diagnosis of PLGA includes adenoid cystic carcinoma, pleomorphic adenoma, and monomorphic adenoma. PLGA should be considered in the differential diagnosis of head and neck tumors, where the cytology suggests on of the above mentioned tumors, even when the clinical findings (involvement of a major salivary gland, lymph node metastasis) is not typical of PLGA.https://actamedica.lfhk.cuni.cz/online_first/18059694.2018.57/PLGASalivary gland tumorsCytologyHistology |
| spellingShingle | Demetrio Tamiolakis Vasilios Thomaidis Ioannis Tsamis Eleni Kariki Athanasia Kotini Maria Lambropoulou Panagiotis Boglou Nikolaos Papadopoulos Polymorphous Low Grade Adenocarcinoma of the Parotid Gland. Cytological, Histological and Immunohistochemical Features and Review of the Literature Acta Medica PLGA Salivary gland tumors Cytology Histology |
| title | Polymorphous Low Grade Adenocarcinoma of the Parotid Gland. Cytological, Histological and Immunohistochemical Features and Review of the Literature |
| title_full | Polymorphous Low Grade Adenocarcinoma of the Parotid Gland. Cytological, Histological and Immunohistochemical Features and Review of the Literature |
| title_fullStr | Polymorphous Low Grade Adenocarcinoma of the Parotid Gland. Cytological, Histological and Immunohistochemical Features and Review of the Literature |
| title_full_unstemmed | Polymorphous Low Grade Adenocarcinoma of the Parotid Gland. Cytological, Histological and Immunohistochemical Features and Review of the Literature |
| title_short | Polymorphous Low Grade Adenocarcinoma of the Parotid Gland. Cytological, Histological and Immunohistochemical Features and Review of the Literature |
| title_sort | polymorphous low grade adenocarcinoma of the parotid gland cytological histological and immunohistochemical features and review of the literature |
| topic | PLGA Salivary gland tumors Cytology Histology |
| url | https://actamedica.lfhk.cuni.cz/online_first/18059694.2018.57/ |
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