Genetic Variation in the 3'-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese Population.
NBN plays a crucial role in carcinogenesis as a core component for both homologous recombination (HR) and non-homologous end-joining (NHEJ) DNA double-strand breaks (DSBs) repair pathways. Genetic variants in the NBN gene have been associated with multiple cancers risk, suggesting pleiotropic effect...
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| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4581712?pdf=render |
| _version_ | 1818020750492172288 |
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| author | Ping Sun Jiangbo Du Xun Zhu Chuanli Ren Lan Xie Ningbin Dai Yayun Gu Caiwang Yan Juncheng Dai Hongxia Ma Yue Jiang Jiaping Chen Zhibin Hu Hongbing Shen Haorong Wu Guangfu Jin |
| author_facet | Ping Sun Jiangbo Du Xun Zhu Chuanli Ren Lan Xie Ningbin Dai Yayun Gu Caiwang Yan Juncheng Dai Hongxia Ma Yue Jiang Jiaping Chen Zhibin Hu Hongbing Shen Haorong Wu Guangfu Jin |
| author_sort | Ping Sun |
| collection | DOAJ |
| description | NBN plays a crucial role in carcinogenesis as a core component for both homologous recombination (HR) and non-homologous end-joining (NHEJ) DNA double-strand breaks (DSBs) repair pathways. Genetic variants in the NBN gene have been associated with multiple cancers risk, suggesting pleiotropic effect on cancer. We hypothesized that genetic variants in the NBN gene may modify the risk of gastric cancer. To test this hypothesis, we evaluated the association between four potentially functional single nucleotide polymorphisms in NBN and gastric cancer risk in a case-control study of 1,140 gastric cancer cases and 1,547 controls in a Chinese population. We found that the A allele of rs10464867 (G>A) was significantly associated with a decreased risk of gastric cancer (odds ratio [OR] = 0.81, 95% confidence interval [95% CI] = 0.71-0.94; P = 4.71×10-3). Furthermore, the association between A allele of rs10464867 and decreased risk of gastric cancer was more significantly in elder individuals (per-allele OR = 0.72[0.59-0.88], P = 1.07×10-3), and male individuals (per-allele OR = 0.73[0.62-0.87], P = 3.68×10-4). We further conducted a haplotype analysis and identified that the NBN Ars10464867Grs14448Grs1063053 haplotype conferred stronger protective effect on gastric cancer (OR = 0.76[0.65-0.89], P = 6.39×10-4). In summary, these findings indicate that genetic variants at NBN gene may contribute to gastric cancer susceptibility and may further advance our understanding of NBN gene in cancer development. |
| first_indexed | 2024-04-14T08:09:47Z |
| format | Article |
| id | doaj.art-4cedbb9d7eb44c93a2b313ae3bb7d609 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T08:09:47Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4cedbb9d7eb44c93a2b313ae3bb7d6092022-12-22T02:04:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01109e013905910.1371/journal.pone.0139059Genetic Variation in the 3'-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese Population.Ping SunJiangbo DuXun ZhuChuanli RenLan XieNingbin DaiYayun GuCaiwang YanJuncheng DaiHongxia MaYue JiangJiaping ChenZhibin HuHongbing ShenHaorong WuGuangfu JinNBN plays a crucial role in carcinogenesis as a core component for both homologous recombination (HR) and non-homologous end-joining (NHEJ) DNA double-strand breaks (DSBs) repair pathways. Genetic variants in the NBN gene have been associated with multiple cancers risk, suggesting pleiotropic effect on cancer. We hypothesized that genetic variants in the NBN gene may modify the risk of gastric cancer. To test this hypothesis, we evaluated the association between four potentially functional single nucleotide polymorphisms in NBN and gastric cancer risk in a case-control study of 1,140 gastric cancer cases and 1,547 controls in a Chinese population. We found that the A allele of rs10464867 (G>A) was significantly associated with a decreased risk of gastric cancer (odds ratio [OR] = 0.81, 95% confidence interval [95% CI] = 0.71-0.94; P = 4.71×10-3). Furthermore, the association between A allele of rs10464867 and decreased risk of gastric cancer was more significantly in elder individuals (per-allele OR = 0.72[0.59-0.88], P = 1.07×10-3), and male individuals (per-allele OR = 0.73[0.62-0.87], P = 3.68×10-4). We further conducted a haplotype analysis and identified that the NBN Ars10464867Grs14448Grs1063053 haplotype conferred stronger protective effect on gastric cancer (OR = 0.76[0.65-0.89], P = 6.39×10-4). In summary, these findings indicate that genetic variants at NBN gene may contribute to gastric cancer susceptibility and may further advance our understanding of NBN gene in cancer development.http://europepmc.org/articles/PMC4581712?pdf=render |
| spellingShingle | Ping Sun Jiangbo Du Xun Zhu Chuanli Ren Lan Xie Ningbin Dai Yayun Gu Caiwang Yan Juncheng Dai Hongxia Ma Yue Jiang Jiaping Chen Zhibin Hu Hongbing Shen Haorong Wu Guangfu Jin Genetic Variation in the 3'-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese Population. PLoS ONE |
| title | Genetic Variation in the 3'-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese Population. |
| title_full | Genetic Variation in the 3'-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese Population. |
| title_fullStr | Genetic Variation in the 3'-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese Population. |
| title_full_unstemmed | Genetic Variation in the 3'-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese Population. |
| title_short | Genetic Variation in the 3'-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese Population. |
| title_sort | genetic variation in the 3 untranslated region of nbn gene is associated with gastric cancer risk in a chinese population |
| url | http://europepmc.org/articles/PMC4581712?pdf=render |
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