Improved Accuracy and Sensitivity in Diagnosis and Staging of Lung Cancer with Systematic and Combined Endobronchial and Endoscopic Ultrasound (EBUS-EUS): Experience from a Tertiary Center
Background: Combined endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and endoscopic ultrasound-guided tissue acquisition (EUS-TA) are accurate procedures for the diagnosis and staging of mediastinal lymph nodes (MLNs) in lung cancer. However, the respective contribution...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/16/4/728 |
| _version_ | 1797298685057433600 |
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| author | Abdenor Badaoui Marion De Wergifosse Benoit Rondelet Pierre H. Deprez Claudia Stanciu-Pop Laurent Bairy Philippe Eucher Monique Delos Sebahat Ocak Cédric Gillain Fabrice Duplaquet Lionel Pirard |
| author_facet | Abdenor Badaoui Marion De Wergifosse Benoit Rondelet Pierre H. Deprez Claudia Stanciu-Pop Laurent Bairy Philippe Eucher Monique Delos Sebahat Ocak Cédric Gillain Fabrice Duplaquet Lionel Pirard |
| author_sort | Abdenor Badaoui |
| collection | DOAJ |
| description | Background: Combined endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and endoscopic ultrasound-guided tissue acquisition (EUS-TA) are accurate procedures for the diagnosis and staging of mediastinal lymph nodes (MLNs) in lung cancer. However, the respective contribution of separate and combined procedures in diagnosis and staging has not been fully studied. The aim of this study was to assess their respective performances. Methods: Patients with suspected malignant MLNs in lung cancer or recurrence identified by PET-CT who underwent combined EBUS-TBNA and EUS-TA were retrospectively reviewed. Results: A total of 141 patients underwent both procedures. Correct diagnosis was obtained in 82% with EBUS-TBNA, 91% with EUS-TA, and 94% with the combined procedure. The overall sensitivity, specificity, and positive and negative predictive values (PPV and NPV) of EBUS-TBNA, EUS-TA, and the combined procedure for diagnosing malignancy were [75%, 100%, 100%, 58%], [87%, 100%, 100%, 75%], and [93%, 100%, 100%, 80%], respectively, with a significantly better sensitivity of the combined procedure (<i>p</i> < 0.0001). Staging (82/141 patients) was correctly assessed in 74% with EBUS-TBNA, 68% with EUS-TA, and 85% with the combined procedure. The overall sensitivity, specificity, PPV, and NPV of EBUS-TBNA, EUS-TA, and the combined procedure for lung cancer staging were [62%, 100%, 100%, 55%], [54%, 100%, 100%, 50%], and [79%, 100%, 100%, 68%], respectively, significantly better in terms of sensitivity for the combined procedure (<i>p</i> < 0.001). Conclusion: The combined EBUS-EUS approach in lung cancer patients showed better accuracy and sensitivity in diagnosis and staging when compared with EBUS-TBNA and EUS-TA alone. |
| first_indexed | 2024-03-07T22:38:33Z |
| format | Article |
| id | doaj.art-4cee5e17282c4d2c86768296435db024 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-07T22:38:33Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-4cee5e17282c4d2c86768296435db0242024-02-23T15:10:43ZengMDPI AGCancers2072-66942024-02-0116472810.3390/cancers16040728Improved Accuracy and Sensitivity in Diagnosis and Staging of Lung Cancer with Systematic and Combined Endobronchial and Endoscopic Ultrasound (EBUS-EUS): Experience from a Tertiary CenterAbdenor Badaoui0Marion De Wergifosse1Benoit Rondelet2Pierre H. Deprez3Claudia Stanciu-Pop4Laurent Bairy5Philippe Eucher6Monique Delos7Sebahat Ocak8Cédric Gillain9Fabrice Duplaquet10Lionel Pirard11Department of Gastroenterology and Hepatology, CHU UCL Namur, Université catholique de Louvain, 5530 Yvoir, BelgiumDepartment of Pneumology, CHU UCL Namur, Université catholique de Louvain, 5530 Yvoir, BelgiumDepartment of Vascular and Thoracic Surgery, CHU UCL Namur, Université catholique de Louvain, 5530 Yvoir, BelgiumDepartment of Gastroenterology and Hepatology, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, 1200 Bruxelles, BelgiumDepartment of Pathological Anatomy, CHU UCL Namur, Université catholique de Louvain, 5530 Yvoir, BelgiumDepartment of Anesthesiology, CHU UCL Namur, Université catholique de Louvain, 5530 Yvoir, BelgiumDepartment of Vascular and Thoracic Surgery, CHU UCL Namur, Université catholique de Louvain, 5530 Yvoir, BelgiumDepartment of Pathological Anatomy, CHU UCL Namur, Université catholique de Louvain, 5530 Yvoir, BelgiumDepartment of Pneumology, CHU UCL Namur, Université catholique de Louvain, 5530 Yvoir, BelgiumDepartment of Gastroenterology and Hepatology, CHU UCL Namur, Université catholique de Louvain, 5530 Yvoir, BelgiumDepartment of Pneumology, CHU UCL Namur, Université catholique de Louvain, 5530 Yvoir, BelgiumDepartment of Pneumology, CHU UCL Namur, Université catholique de Louvain, 5530 Yvoir, BelgiumBackground: Combined endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and endoscopic ultrasound-guided tissue acquisition (EUS-TA) are accurate procedures for the diagnosis and staging of mediastinal lymph nodes (MLNs) in lung cancer. However, the respective contribution of separate and combined procedures in diagnosis and staging has not been fully studied. The aim of this study was to assess their respective performances. Methods: Patients with suspected malignant MLNs in lung cancer or recurrence identified by PET-CT who underwent combined EBUS-TBNA and EUS-TA were retrospectively reviewed. Results: A total of 141 patients underwent both procedures. Correct diagnosis was obtained in 82% with EBUS-TBNA, 91% with EUS-TA, and 94% with the combined procedure. The overall sensitivity, specificity, and positive and negative predictive values (PPV and NPV) of EBUS-TBNA, EUS-TA, and the combined procedure for diagnosing malignancy were [75%, 100%, 100%, 58%], [87%, 100%, 100%, 75%], and [93%, 100%, 100%, 80%], respectively, with a significantly better sensitivity of the combined procedure (<i>p</i> < 0.0001). Staging (82/141 patients) was correctly assessed in 74% with EBUS-TBNA, 68% with EUS-TA, and 85% with the combined procedure. The overall sensitivity, specificity, PPV, and NPV of EBUS-TBNA, EUS-TA, and the combined procedure for lung cancer staging were [62%, 100%, 100%, 55%], [54%, 100%, 100%, 50%], and [79%, 100%, 100%, 68%], respectively, significantly better in terms of sensitivity for the combined procedure (<i>p</i> < 0.001). Conclusion: The combined EBUS-EUS approach in lung cancer patients showed better accuracy and sensitivity in diagnosis and staging when compared with EBUS-TBNA and EUS-TA alone.https://www.mdpi.com/2072-6694/16/4/728mediastinal staginglung cancerendoscopic ultrasoundendobronchial ultrasoundmediastinoscopy |
| spellingShingle | Abdenor Badaoui Marion De Wergifosse Benoit Rondelet Pierre H. Deprez Claudia Stanciu-Pop Laurent Bairy Philippe Eucher Monique Delos Sebahat Ocak Cédric Gillain Fabrice Duplaquet Lionel Pirard Improved Accuracy and Sensitivity in Diagnosis and Staging of Lung Cancer with Systematic and Combined Endobronchial and Endoscopic Ultrasound (EBUS-EUS): Experience from a Tertiary Center Cancers mediastinal staging lung cancer endoscopic ultrasound endobronchial ultrasound mediastinoscopy |
| title | Improved Accuracy and Sensitivity in Diagnosis and Staging of Lung Cancer with Systematic and Combined Endobronchial and Endoscopic Ultrasound (EBUS-EUS): Experience from a Tertiary Center |
| title_full | Improved Accuracy and Sensitivity in Diagnosis and Staging of Lung Cancer with Systematic and Combined Endobronchial and Endoscopic Ultrasound (EBUS-EUS): Experience from a Tertiary Center |
| title_fullStr | Improved Accuracy and Sensitivity in Diagnosis and Staging of Lung Cancer with Systematic and Combined Endobronchial and Endoscopic Ultrasound (EBUS-EUS): Experience from a Tertiary Center |
| title_full_unstemmed | Improved Accuracy and Sensitivity in Diagnosis and Staging of Lung Cancer with Systematic and Combined Endobronchial and Endoscopic Ultrasound (EBUS-EUS): Experience from a Tertiary Center |
| title_short | Improved Accuracy and Sensitivity in Diagnosis and Staging of Lung Cancer with Systematic and Combined Endobronchial and Endoscopic Ultrasound (EBUS-EUS): Experience from a Tertiary Center |
| title_sort | improved accuracy and sensitivity in diagnosis and staging of lung cancer with systematic and combined endobronchial and endoscopic ultrasound ebus eus experience from a tertiary center |
| topic | mediastinal staging lung cancer endoscopic ultrasound endobronchial ultrasound mediastinoscopy |
| url | https://www.mdpi.com/2072-6694/16/4/728 |
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