Diagnostic modality for evaluation of right ventricle in chronic thromboembolic pulmonary hypertension patients
Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive disease of pulmonary hypertension (PH) as a consequence obstructive of pulmonary arteries with thromboembolism. Augmented pulmonary vascular resistance and pulmonary artery pressure (PAP) can ultimately lead to the ri...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2019-01-01
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| Series: | International Journal of the Cardiovascular Academy |
| Subjects: | |
| Online Access: | http://www.ijcva.com/article.asp?issn=2405-8181;year=2019;volume=5;issue=4;spage=152;epage=158;aulast=Oguz |
| _version_ | 1797707387808776192 |
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| author | Mustafa Oguz Tarik Kivrak Murat Sunbul Fuad Dede Bedrettin Yildizeli Bulent Mutlu |
| author_facet | Mustafa Oguz Tarik Kivrak Murat Sunbul Fuad Dede Bedrettin Yildizeli Bulent Mutlu |
| author_sort | Mustafa Oguz |
| collection | DOAJ |
| description | Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive disease of pulmonary hypertension (PH) as a consequence obstructive of pulmonary arteries with thromboembolism. Augmented pulmonary vascular resistance and pulmonary artery pressure (PAP) can ultimately lead to the right ventricular dysfunction, which leads to adaptive and maladaptive changes. Right ventricle (RV) remodeling can cause clinical deterioration and RV failure. Aims and Objectives: We aimed to evaluate the RV functions with a new diagnostic modality 2-deoxy-2-(18F)-fluoro-D-glucose (FDG)-positron emission tomography (PET) in patients with CTEPH. Materials and Methods: We included 53 patients diagnosed with CTEPH who were planned to have pulmonary thromboendarterectomy (PEA) and did not have any contraindication for cardiac PET/computed tomography (CT). We performed transthoracic echo, cardiac PET/CT, 6-minute walk distance (6-MWT), and right heart catheterization 1 week before PEA surgery. Results: The patients divided into two groups according to RV/left ventricle (LV) FDG-PET uptake ratio, RV/LV ≤1, and RV/LV >1. Six-MWD was significantly higher in the RV/LV ≤1 group (P = 0.005). Pro-BNP was considerably higher in the RV/LV >1 group (P = 0.041). Conclusion: The present study aims to demonstrate the RV/LV FDG-PET uptake ratio could be used in the noninvasive diagnostic method in diagnosing, treatment strategy, and clinical follow-up in patients with CTEPH. |
| first_indexed | 2024-03-12T06:05:39Z |
| format | Article |
| id | doaj.art-4ceed762d4f7498f8b203254b563678f |
| institution | Directory Open Access Journal |
| issn | 2405-8181 2405-819X |
| language | English |
| last_indexed | 2024-03-12T06:05:39Z |
| publishDate | 2019-01-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | International Journal of the Cardiovascular Academy |
| spelling | doaj.art-4ceed762d4f7498f8b203254b563678f2023-09-03T03:35:48ZengGalenos Publishing HouseInternational Journal of the Cardiovascular Academy2405-81812405-819X2019-01-015415215810.4103/IJCA.IJCA_35_19Diagnostic modality for evaluation of right ventricle in chronic thromboembolic pulmonary hypertension patientsMustafa OguzTarik KivrakMurat SunbulFuad DedeBedrettin YildizeliBulent MutluBackground: Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive disease of pulmonary hypertension (PH) as a consequence obstructive of pulmonary arteries with thromboembolism. Augmented pulmonary vascular resistance and pulmonary artery pressure (PAP) can ultimately lead to the right ventricular dysfunction, which leads to adaptive and maladaptive changes. Right ventricle (RV) remodeling can cause clinical deterioration and RV failure. Aims and Objectives: We aimed to evaluate the RV functions with a new diagnostic modality 2-deoxy-2-(18F)-fluoro-D-glucose (FDG)-positron emission tomography (PET) in patients with CTEPH. Materials and Methods: We included 53 patients diagnosed with CTEPH who were planned to have pulmonary thromboendarterectomy (PEA) and did not have any contraindication for cardiac PET/computed tomography (CT). We performed transthoracic echo, cardiac PET/CT, 6-minute walk distance (6-MWT), and right heart catheterization 1 week before PEA surgery. Results: The patients divided into two groups according to RV/left ventricle (LV) FDG-PET uptake ratio, RV/LV ≤1, and RV/LV >1. Six-MWD was significantly higher in the RV/LV ≤1 group (P = 0.005). Pro-BNP was considerably higher in the RV/LV >1 group (P = 0.041). Conclusion: The present study aims to demonstrate the RV/LV FDG-PET uptake ratio could be used in the noninvasive diagnostic method in diagnosing, treatment strategy, and clinical follow-up in patients with CTEPH.http://www.ijcva.com/article.asp?issn=2405-8181;year=2019;volume=5;issue=4;spage=152;epage=158;aulast=Oguzcardiac fluoro-d-glucose positron emission tomographychronic thromboembolic pulmonary hypertensionpulmonary vascular resistanceright ventricular remodeling |
| spellingShingle | Mustafa Oguz Tarik Kivrak Murat Sunbul Fuad Dede Bedrettin Yildizeli Bulent Mutlu Diagnostic modality for evaluation of right ventricle in chronic thromboembolic pulmonary hypertension patients International Journal of the Cardiovascular Academy cardiac fluoro-d-glucose positron emission tomography chronic thromboembolic pulmonary hypertension pulmonary vascular resistance right ventricular remodeling |
| title | Diagnostic modality for evaluation of right ventricle in chronic thromboembolic pulmonary hypertension patients |
| title_full | Diagnostic modality for evaluation of right ventricle in chronic thromboembolic pulmonary hypertension patients |
| title_fullStr | Diagnostic modality for evaluation of right ventricle in chronic thromboembolic pulmonary hypertension patients |
| title_full_unstemmed | Diagnostic modality for evaluation of right ventricle in chronic thromboembolic pulmonary hypertension patients |
| title_short | Diagnostic modality for evaluation of right ventricle in chronic thromboembolic pulmonary hypertension patients |
| title_sort | diagnostic modality for evaluation of right ventricle in chronic thromboembolic pulmonary hypertension patients |
| topic | cardiac fluoro-d-glucose positron emission tomography chronic thromboembolic pulmonary hypertension pulmonary vascular resistance right ventricular remodeling |
| url | http://www.ijcva.com/article.asp?issn=2405-8181;year=2019;volume=5;issue=4;spage=152;epage=158;aulast=Oguz |
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