Chemical Profiling and Antioxidant and Anti-Amyloid Capacities of <i>Salvia fruticosa</i> Extracts from Greece
An increasingly common ailment in elderly persons is Alzheimer’s disease (AD), a neurodegenerative illness. Present treatment is restricted to alleviating symptoms; hence, there is a requirement to develop an effective approach to AD treatment. <i>Salvia fruticosa</i> (SF) is a medicinal...
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| Format: | Article |
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MDPI AG
2023-09-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/12/18/3191 |
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| author | Antonis Ververis Sotiris Kyriakou Kristia Ioannou Paschalina S. Chatzopoulou Mihalis I. Panayiotidis Michael Plioukas Kyproula Christodoulou |
| author_facet | Antonis Ververis Sotiris Kyriakou Kristia Ioannou Paschalina S. Chatzopoulou Mihalis I. Panayiotidis Michael Plioukas Kyproula Christodoulou |
| author_sort | Antonis Ververis |
| collection | DOAJ |
| description | An increasingly common ailment in elderly persons is Alzheimer’s disease (AD), a neurodegenerative illness. Present treatment is restricted to alleviating symptoms; hence, there is a requirement to develop an effective approach to AD treatment. <i>Salvia fruticosa</i> (SF) is a medicinal plant with a documented neuroprotective potential. To identify extracts of increased neuroprotectivity, we partitioned the methanolic extract of SF aerial parts from Greece into several fractions, by employing solvents of different polarities. The fractions were chemically identified and evaluated for their antioxidancy and anti-neurotoxic potential against amyloid beta peptides 25–35 (Aβ<sub>25–35</sub>). Carnosol and carnosic acid were among the prominent compounds, while all partitions showed significant antioxidant capacity, with the diethyl ether and ethyl acetate partitions being the most potent. These, along with the aqueous and the butanolic fractions, demonstrated statistically significant anti-neurotoxic potential. Thus, our findings further validate the neuroprotective potential of SF and support its ethnopharmacological usage as an antioxidant. The particular properties found define SF as a promising source for obtaining extracts or bioactive compounds, possibly beneficial for generating AD-related functional foods or medications. Finally, our results encourage plant extract partitioning for acquiring fractions of enhanced biological properties. |
| first_indexed | 2024-03-10T22:13:11Z |
| format | Article |
| id | doaj.art-4cf13ff49a1043489af2fe36057102be |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-10T22:13:11Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-4cf13ff49a1043489af2fe36057102be2023-11-19T12:31:24ZengMDPI AGPlants2223-77472023-09-011218319110.3390/plants12183191Chemical Profiling and Antioxidant and Anti-Amyloid Capacities of <i>Salvia fruticosa</i> Extracts from GreeceAntonis Ververis0Sotiris Kyriakou1Kristia Ioannou2Paschalina S. Chatzopoulou3Mihalis I. Panayiotidis4Michael Plioukas5Kyproula Christodoulou6Neurogenetics Department, The Cyprus Institute of Neurology and Genetics, Nicosia 2371, CyprusDepartment of Cancer Genetics, Therapeutics and Ultrastructural Pathology, The Cyprus Institute of Neurology and Genetics, Nicosia 2371, CyprusNeurogenetics Department, The Cyprus Institute of Neurology and Genetics, Nicosia 2371, CyprusHellenic Agricultural Organization-DIMITRA, Institute of Plant Breeding and Genetic Resources, 57001 Thessaloniki, GreeceDepartment of Cancer Genetics, Therapeutics and Ultrastructural Pathology, The Cyprus Institute of Neurology and Genetics, Nicosia 2371, CyprusDepartment of Life and Health Sciences, School of Sciences and Engineering, University of Nicosia, Nicosia 2417, CyprusNeurogenetics Department, The Cyprus Institute of Neurology and Genetics, Nicosia 2371, CyprusAn increasingly common ailment in elderly persons is Alzheimer’s disease (AD), a neurodegenerative illness. Present treatment is restricted to alleviating symptoms; hence, there is a requirement to develop an effective approach to AD treatment. <i>Salvia fruticosa</i> (SF) is a medicinal plant with a documented neuroprotective potential. To identify extracts of increased neuroprotectivity, we partitioned the methanolic extract of SF aerial parts from Greece into several fractions, by employing solvents of different polarities. The fractions were chemically identified and evaluated for their antioxidancy and anti-neurotoxic potential against amyloid beta peptides 25–35 (Aβ<sub>25–35</sub>). Carnosol and carnosic acid were among the prominent compounds, while all partitions showed significant antioxidant capacity, with the diethyl ether and ethyl acetate partitions being the most potent. These, along with the aqueous and the butanolic fractions, demonstrated statistically significant anti-neurotoxic potential. Thus, our findings further validate the neuroprotective potential of SF and support its ethnopharmacological usage as an antioxidant. The particular properties found define SF as a promising source for obtaining extracts or bioactive compounds, possibly beneficial for generating AD-related functional foods or medications. Finally, our results encourage plant extract partitioning for acquiring fractions of enhanced biological properties.https://www.mdpi.com/2223-7747/12/18/3191<i>Salvia fruticosa</i>neuroprotectionplant extractsAlzheimer’s diseasepartitioning |
| spellingShingle | Antonis Ververis Sotiris Kyriakou Kristia Ioannou Paschalina S. Chatzopoulou Mihalis I. Panayiotidis Michael Plioukas Kyproula Christodoulou Chemical Profiling and Antioxidant and Anti-Amyloid Capacities of <i>Salvia fruticosa</i> Extracts from Greece Plants <i>Salvia fruticosa</i> neuroprotection plant extracts Alzheimer’s disease partitioning |
| title | Chemical Profiling and Antioxidant and Anti-Amyloid Capacities of <i>Salvia fruticosa</i> Extracts from Greece |
| title_full | Chemical Profiling and Antioxidant and Anti-Amyloid Capacities of <i>Salvia fruticosa</i> Extracts from Greece |
| title_fullStr | Chemical Profiling and Antioxidant and Anti-Amyloid Capacities of <i>Salvia fruticosa</i> Extracts from Greece |
| title_full_unstemmed | Chemical Profiling and Antioxidant and Anti-Amyloid Capacities of <i>Salvia fruticosa</i> Extracts from Greece |
| title_short | Chemical Profiling and Antioxidant and Anti-Amyloid Capacities of <i>Salvia fruticosa</i> Extracts from Greece |
| title_sort | chemical profiling and antioxidant and anti amyloid capacities of i salvia fruticosa i extracts from greece |
| topic | <i>Salvia fruticosa</i> neuroprotection plant extracts Alzheimer’s disease partitioning |
| url | https://www.mdpi.com/2223-7747/12/18/3191 |
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