The effect of tyrosine residues on α-synuclein fibrillation

The effect of tyrosine residues on α-synuclein fibrillation

Aggregation of the intrinsically disordered protein α-synuclein into ordered amyloid fibrils is implicated in the pathogenesis of Parkinson’s disease. To unravel the role of Tyr residues in α-synuclein fibrillation, we prepared recombinant N-terminal (Y39A) and C-terminal (Y(125,133,136)A) mutants o...

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Bibliographic Details
Main Authors: Katja Pirc, Miha Škarabot, Lea Pogačnik, Eva Žerovnik, natasa poklar ulrih
Format: Article
Language:English
Published: Slovenian Chemical Society 2015-01-01
Series:Acta Chimica Slovenica
Subjects:
α-synuclein
fibrillation
Parkinson’s disease
site-directed mutagenesis
ThT fluorescence
tyrosine
Online Access:https://journals.matheo.si/index.php/ACSi/article/view/882

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