Spectral CT - a new supplementary method for preoperative assessment of pathological grades of esophageal squamous cell carcinoma
Abstract Background Spectral CT imaging parameters have been reported to be useful in the differentiation of pathological grades in different malignancies. This study aims to investigate the value of spectral CT in the quantitative assessment of esophageal squamous cell carcinoma (ESCC) with differe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Medical Imaging |
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| Online Access: | https://doi.org/10.1186/s12880-023-01068-5 |
| _version_ | 1797451041319419904 |
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| author | Yi Wang Weizhong Tian Shuangfeng Tian Liang He Jianguo Xia Ji Zhang |
| author_facet | Yi Wang Weizhong Tian Shuangfeng Tian Liang He Jianguo Xia Ji Zhang |
| author_sort | Yi Wang |
| collection | DOAJ |
| description | Abstract Background Spectral CT imaging parameters have been reported to be useful in the differentiation of pathological grades in different malignancies. This study aims to investigate the value of spectral CT in the quantitative assessment of esophageal squamous cell carcinoma (ESCC) with different degrees of differentiation. Methods There were 191 patients with proven ESCC who underwent enhanced spectral CT from June 2018 to March 2020 retrospectively enrolled. These patients were divided into three groups based on pathological results: well differentiated ESCC, moderately differentiated ESCC, and poorly differentiated ESCC. Virtual monoenergetic 40 keV-equivalent image (VMI40keV), iodine concentration (IC), water concentration (WC), effective atomic number (Eff-Z), and the slope of the spectral curve(λHU) of the arterial phase (AP) and venous phase (VP) were measured or calculated. The quantitative parameters of the three groups were compared by using one-way ANOVA and pairwise comparisons were performed with LSD. Receiver operating characteristic (ROC) analysis was used to evaluate the diagnostic performance of these parameters in poorly differentiated groups and non-poorly differentiated groups. Results There were significant differences in VMI40keV, IC, Eff-Z, and λHU in AP and VP among the three groups (all p < 0.05) except for WC (p > 0.05). The VMI40keV, IC, Eff-Z, and λHU in the poorly differentiated group were significantly higher than those in the other groups both in AP and VP (all p < 0.05). In the ROC analysis, IC performed the best in the identification of the poorly differentiated group and non-poorly differentiated group in VP (AUC = 0.729, Sensitivity = 0.829, and Specificity = 0.569 under the threshold of 21.08 mg/ml). Conclusions Quantitative parameters of spectral CT could offer supplemental information for the preoperative differential diagnosis of ESCC with different degrees of differentiation. |
| first_indexed | 2024-03-09T14:49:14Z |
| format | Article |
| id | doaj.art-4cf1a4fb826f476694aacb7e25a7cf8b |
| institution | Directory Open Access Journal |
| issn | 1471-2342 |
| language | English |
| last_indexed | 2024-03-09T14:49:14Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj.art-4cf1a4fb826f476694aacb7e25a7cf8b2023-11-26T14:35:13ZengBMCBMC Medical Imaging1471-23422023-08-012311810.1186/s12880-023-01068-5Spectral CT - a new supplementary method for preoperative assessment of pathological grades of esophageal squamous cell carcinomaYi Wang0Weizhong Tian1Shuangfeng Tian2Liang He3Jianguo Xia4Ji Zhang5Department of Radiology, Taizhou People’s HospitalDepartment of Radiology, Taizhou People’s HospitalDepartment of Radiology, Taizhou People’s HospitalDepartment of Radiology, Taizhou People’s HospitalDepartment of Radiology, Taizhou People’s HospitalDepartment of Radiology, Taizhou People’s HospitalAbstract Background Spectral CT imaging parameters have been reported to be useful in the differentiation of pathological grades in different malignancies. This study aims to investigate the value of spectral CT in the quantitative assessment of esophageal squamous cell carcinoma (ESCC) with different degrees of differentiation. Methods There were 191 patients with proven ESCC who underwent enhanced spectral CT from June 2018 to March 2020 retrospectively enrolled. These patients were divided into three groups based on pathological results: well differentiated ESCC, moderately differentiated ESCC, and poorly differentiated ESCC. Virtual monoenergetic 40 keV-equivalent image (VMI40keV), iodine concentration (IC), water concentration (WC), effective atomic number (Eff-Z), and the slope of the spectral curve(λHU) of the arterial phase (AP) and venous phase (VP) were measured or calculated. The quantitative parameters of the three groups were compared by using one-way ANOVA and pairwise comparisons were performed with LSD. Receiver operating characteristic (ROC) analysis was used to evaluate the diagnostic performance of these parameters in poorly differentiated groups and non-poorly differentiated groups. Results There were significant differences in VMI40keV, IC, Eff-Z, and λHU in AP and VP among the three groups (all p < 0.05) except for WC (p > 0.05). The VMI40keV, IC, Eff-Z, and λHU in the poorly differentiated group were significantly higher than those in the other groups both in AP and VP (all p < 0.05). In the ROC analysis, IC performed the best in the identification of the poorly differentiated group and non-poorly differentiated group in VP (AUC = 0.729, Sensitivity = 0.829, and Specificity = 0.569 under the threshold of 21.08 mg/ml). Conclusions Quantitative parameters of spectral CT could offer supplemental information for the preoperative differential diagnosis of ESCC with different degrees of differentiation.https://doi.org/10.1186/s12880-023-01068-5Esophageal squamous cell carcinomaSpectral CTPathological grade |
| spellingShingle | Yi Wang Weizhong Tian Shuangfeng Tian Liang He Jianguo Xia Ji Zhang Spectral CT - a new supplementary method for preoperative assessment of pathological grades of esophageal squamous cell carcinoma BMC Medical Imaging Esophageal squamous cell carcinoma Spectral CT Pathological grade |
| title | Spectral CT - a new supplementary method for preoperative assessment of pathological grades of esophageal squamous cell carcinoma |
| title_full | Spectral CT - a new supplementary method for preoperative assessment of pathological grades of esophageal squamous cell carcinoma |
| title_fullStr | Spectral CT - a new supplementary method for preoperative assessment of pathological grades of esophageal squamous cell carcinoma |
| title_full_unstemmed | Spectral CT - a new supplementary method for preoperative assessment of pathological grades of esophageal squamous cell carcinoma |
| title_short | Spectral CT - a new supplementary method for preoperative assessment of pathological grades of esophageal squamous cell carcinoma |
| title_sort | spectral ct a new supplementary method for preoperative assessment of pathological grades of esophageal squamous cell carcinoma |
| topic | Esophageal squamous cell carcinoma Spectral CT Pathological grade |
| url | https://doi.org/10.1186/s12880-023-01068-5 |
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