Abnormal regional signal in the left cerebellum as a potential neuroimaging biomarker of sudden sensorineural hearing loss
ObjectiveWhile prior reports have characterized visible changes in neuroimaging findings in individuals suffering from sudden sensorineural hearing loss (SSNHL), the utility of regional homogeneity (ReHo) as a means of diagnosing SSNHL has yet to be established. The present study was thus conducted...
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.967391/full |
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| author | Lei Liu Jun Fan Hui Zhan Junli Huang Rui Cao Xiaoran Xiang Shuai Tian Hongwei Ren Miao Tong Qian Li |
| author_facet | Lei Liu Jun Fan Hui Zhan Junli Huang Rui Cao Xiaoran Xiang Shuai Tian Hongwei Ren Miao Tong Qian Li |
| author_sort | Lei Liu |
| collection | DOAJ |
| description | ObjectiveWhile prior reports have characterized visible changes in neuroimaging findings in individuals suffering from sudden sensorineural hearing loss (SSNHL), the utility of regional homogeneity (ReHo) as a means of diagnosing SSNHL has yet to be established. The present study was thus conducted to assess ReHo abnormalities in SSNHL patients and to establish whether these abnormalities offer value as a diagnostic neuroimaging biomarker of SSNHL through a support vector machine (SVM) analysis approach.MethodsResting-state functional magnetic resonance imaging (rs-fMRI) analyses of 27 SSNHL patients and 27 normal controls were conducted, with the resultant imaging data then being analyzed based on a combination of ReHo and SVM approaches.ResultsRelative to normal control individuals, patients diagnosed with SSNHL exhibited significant reductions in ReHo values in the left cerebellum, bilateral inferior temporal gyrus (ITG), left superior temporal pole (STP), right parahippocampal gyrus (PHG), left posterior cingulum cortex (PCC), and right superior frontal gyrus (SFG). SVM analyses suggested that reduced ReHo values in the left cerebellum were associated with high levels of diagnostic accuracy (96.30%, 52/54), sensitivity (92.59%, 25/27), and specificity (100.00%, 27/27) when distinguishing between SSNHL patients and control individuals.ConclusionThese data suggest that SSNHL patients exhibit abnormal resting-state neurological activity, with changes in the ReHo of the left cerebellum offering value as a diagnostic neuroimaging biomarker associated with this condition. |
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| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-13T20:29:20Z |
| publishDate | 2022-07-01 |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-4cf218ba411d4d82945c7f255248dd872022-12-22T02:31:14ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-07-011310.3389/fpsyt.2022.967391967391Abnormal regional signal in the left cerebellum as a potential neuroimaging biomarker of sudden sensorineural hearing lossLei Liu0Jun Fan1Hui Zhan2Junli Huang3Rui Cao4Xiaoran Xiang5Shuai Tian6Hongwei Ren7Miao Tong8Qian Li9Department of Otorhinolaryngology, Tianyou Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, ChinaDepartment of Otorhinolaryngology, Tianyou Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, ChinaDepartment of Otorhinolaryngology, Tianyou Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, ChinaDepartment of Medical Imaging, Tianyou Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, ChinaDepartment of Otorhinolaryngology, Tianyou Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, ChinaDepartment of Otorhinolaryngology, Tianyou Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, ChinaDepartment of Otorhinolaryngology, Tianyou Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, ChinaDepartment of Medical Imaging, Tianyou Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, ChinaDepartment of Stomatology, Tianyou Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, ChinaDepartment of Otorhinolaryngology, Tianyou Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, ChinaObjectiveWhile prior reports have characterized visible changes in neuroimaging findings in individuals suffering from sudden sensorineural hearing loss (SSNHL), the utility of regional homogeneity (ReHo) as a means of diagnosing SSNHL has yet to be established. The present study was thus conducted to assess ReHo abnormalities in SSNHL patients and to establish whether these abnormalities offer value as a diagnostic neuroimaging biomarker of SSNHL through a support vector machine (SVM) analysis approach.MethodsResting-state functional magnetic resonance imaging (rs-fMRI) analyses of 27 SSNHL patients and 27 normal controls were conducted, with the resultant imaging data then being analyzed based on a combination of ReHo and SVM approaches.ResultsRelative to normal control individuals, patients diagnosed with SSNHL exhibited significant reductions in ReHo values in the left cerebellum, bilateral inferior temporal gyrus (ITG), left superior temporal pole (STP), right parahippocampal gyrus (PHG), left posterior cingulum cortex (PCC), and right superior frontal gyrus (SFG). SVM analyses suggested that reduced ReHo values in the left cerebellum were associated with high levels of diagnostic accuracy (96.30%, 52/54), sensitivity (92.59%, 25/27), and specificity (100.00%, 27/27) when distinguishing between SSNHL patients and control individuals.ConclusionThese data suggest that SSNHL patients exhibit abnormal resting-state neurological activity, with changes in the ReHo of the left cerebellum offering value as a diagnostic neuroimaging biomarker associated with this condition.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.967391/fullsudden sensorineural hearing lossregional homogeneityresting-state fMRIsupport vector machineneuroimaging biomarker |
| spellingShingle | Lei Liu Jun Fan Hui Zhan Junli Huang Rui Cao Xiaoran Xiang Shuai Tian Hongwei Ren Miao Tong Qian Li Abnormal regional signal in the left cerebellum as a potential neuroimaging biomarker of sudden sensorineural hearing loss Frontiers in Psychiatry sudden sensorineural hearing loss regional homogeneity resting-state fMRI support vector machine neuroimaging biomarker |
| title | Abnormal regional signal in the left cerebellum as a potential neuroimaging biomarker of sudden sensorineural hearing loss |
| title_full | Abnormal regional signal in the left cerebellum as a potential neuroimaging biomarker of sudden sensorineural hearing loss |
| title_fullStr | Abnormal regional signal in the left cerebellum as a potential neuroimaging biomarker of sudden sensorineural hearing loss |
| title_full_unstemmed | Abnormal regional signal in the left cerebellum as a potential neuroimaging biomarker of sudden sensorineural hearing loss |
| title_short | Abnormal regional signal in the left cerebellum as a potential neuroimaging biomarker of sudden sensorineural hearing loss |
| title_sort | abnormal regional signal in the left cerebellum as a potential neuroimaging biomarker of sudden sensorineural hearing loss |
| topic | sudden sensorineural hearing loss regional homogeneity resting-state fMRI support vector machine neuroimaging biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.967391/full |
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