Remote Ischemic Postconditioning for Ischemic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Background: Remote ischemic postconditioning (RIPostC) appears to protect distant organs from ischemia-reperfusion injury (IRI). However, cerebral protection results have remained inconclusive. In the present study, a meta-analysis was performed to compare stroke patients with and without RIPostC. M...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2018-01-01
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| Series: | Chinese Medical Journal |
| Subjects: | |
| Online Access: | http://www.cmj.org/article.asp?issn=0366-6999;year=2018;volume=131;issue=8;spage=956;epage=965;aulast=Zhao |
| _version_ | 1818152085591425024 |
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| author | Jing-Jing Zhao Hui Xiao Wen-Bo Zhao Xiao-Pei Zhang Yu Xiang Zeng-Jie Ye Miao-Miao Mo Xue-Ting Peng Lin Wei |
| author_facet | Jing-Jing Zhao Hui Xiao Wen-Bo Zhao Xiao-Pei Zhang Yu Xiang Zeng-Jie Ye Miao-Miao Mo Xue-Ting Peng Lin Wei |
| author_sort | Jing-Jing Zhao |
| collection | DOAJ |
| description | Background: Remote ischemic postconditioning (RIPostC) appears to protect distant organs from ischemia-reperfusion injury (IRI). However, cerebral protection results have remained inconclusive. In the present study, a meta-analysis was performed to compare stroke patients with and without RIPostC.
Methods: CNKI, WanFang, VIP, CBM, PubMed, and Cochrane Library databases were searched up to July 2016. Data were analyzed using both fixed-effects and random-effects models by Review Manager. For each outcome, risk ratio (RR) and mean difference (MD) with 95% confidence interval (CI) were calculated.
Results: A total of 13 randomized controlled trials that enrolled a total of 794 study participants who suffered from or are at risk for brain IRI were selected. Compared with controls, RIPostC significantly reduced the recurrence of stroke or transient ischemic attacks (RR = 0.37; 95% CI: 0.26–0.55; P < 0.00001). Moreover, it can reduce the levels of the National Institutes of Health Stroke Scale score (MD: 1.96; 95% CI: 2.18–1.75; P < 0.00001), modified Rankin Scale score (MD: 0.73; 95% CI: 1.20–0.25; P = 0.00300), and high-sensitivity C-reactive protein (MD: 4.17; 95% CI: 4.71–3.62; P < 0.00001) between the two groups. There was no side effect of RIPostC using tourniquet cuff around the limb on ischemic stroke treating based on different intervention duration.
Conclusion: The present meta-analysis suggests that RIPostC might offer cerebral protection for stroke patients suffering from or are at risk of brain IRI. |
| first_indexed | 2024-12-11T13:49:07Z |
| format | Article |
| id | doaj.art-4cf2aa0003c24108988ec0b5637d9b51 |
| institution | Directory Open Access Journal |
| issn | 0366-6999 |
| language | English |
| last_indexed | 2024-12-11T13:49:07Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-4cf2aa0003c24108988ec0b5637d9b512022-12-22T01:04:20ZengWolters KluwerChinese Medical Journal0366-69992018-01-01131895696510.4103/0366-6999.229892Remote Ischemic Postconditioning for Ischemic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsJing-Jing ZhaoHui XiaoWen-Bo ZhaoXiao-Pei ZhangYu XiangZeng-Jie YeMiao-Miao MoXue-Ting PengLin WeiBackground: Remote ischemic postconditioning (RIPostC) appears to protect distant organs from ischemia-reperfusion injury (IRI). However, cerebral protection results have remained inconclusive. In the present study, a meta-analysis was performed to compare stroke patients with and without RIPostC. Methods: CNKI, WanFang, VIP, CBM, PubMed, and Cochrane Library databases were searched up to July 2016. Data were analyzed using both fixed-effects and random-effects models by Review Manager. For each outcome, risk ratio (RR) and mean difference (MD) with 95% confidence interval (CI) were calculated. Results: A total of 13 randomized controlled trials that enrolled a total of 794 study participants who suffered from or are at risk for brain IRI were selected. Compared with controls, RIPostC significantly reduced the recurrence of stroke or transient ischemic attacks (RR = 0.37; 95% CI: 0.26–0.55; P < 0.00001). Moreover, it can reduce the levels of the National Institutes of Health Stroke Scale score (MD: 1.96; 95% CI: 2.18–1.75; P < 0.00001), modified Rankin Scale score (MD: 0.73; 95% CI: 1.20–0.25; P = 0.00300), and high-sensitivity C-reactive protein (MD: 4.17; 95% CI: 4.71–3.62; P < 0.00001) between the two groups. There was no side effect of RIPostC using tourniquet cuff around the limb on ischemic stroke treating based on different intervention duration. Conclusion: The present meta-analysis suggests that RIPostC might offer cerebral protection for stroke patients suffering from or are at risk of brain IRI.http://www.cmj.org/article.asp?issn=0366-6999;year=2018;volume=131;issue=8;spage=956;epage=965;aulast=ZhaoIschemic Stroke; Meta-Analysis; Remote Ischemic Postconditioning |
| spellingShingle | Jing-Jing Zhao Hui Xiao Wen-Bo Zhao Xiao-Pei Zhang Yu Xiang Zeng-Jie Ye Miao-Miao Mo Xue-Ting Peng Lin Wei Remote Ischemic Postconditioning for Ischemic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Chinese Medical Journal Ischemic Stroke; Meta-Analysis; Remote Ischemic Postconditioning |
| title | Remote Ischemic Postconditioning for Ischemic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_full | Remote Ischemic Postconditioning for Ischemic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_fullStr | Remote Ischemic Postconditioning for Ischemic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_full_unstemmed | Remote Ischemic Postconditioning for Ischemic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_short | Remote Ischemic Postconditioning for Ischemic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_sort | remote ischemic postconditioning for ischemic stroke a systematic review and meta analysis of randomized controlled trials |
| topic | Ischemic Stroke; Meta-Analysis; Remote Ischemic Postconditioning |
| url | http://www.cmj.org/article.asp?issn=0366-6999;year=2018;volume=131;issue=8;spage=956;epage=965;aulast=Zhao |
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