Comparative analysis of chlorambucil-induced DNA lesion formation and repair in a spectrum of different human cell systems

Comparative analysis of chlorambucil-induced DNA lesion formation and repair in a spectrum of different human cell systems

Chlorambucil (CLB) belongs to the class of nitrogen mustards (NMs), which are highly reactive bifunctional alkylating agents and were the first chemotherapeutic agents developed. They form DNA interstrand crosslinks (ICLs), which cause a blockage of DNA strand separation, inhibiting essential proces...

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Bibliographic Details
Main Authors: Sarah Ceylan Krassnig, Marina Mäser, Nicola Anna Probst, Jens Werner, Charlotte Schlett, Nina Schumann, Gudrun von Scheven, Aswin Mangerich, Alexander Bürkle
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Toxicology Reports
Subjects:
Nitrogen mustard
Chlorambucil
Interstrand crosslink
Monoalkylated DNA adducts
DNA repair kinetics
Mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750023000100

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http://www.sciencedirect.com/science/article/pii/S2214750023000100

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