Gray Matter and White Matter Abnormalities in Temporal Lobe Epilepsy Patients with and without Hippocampal Sclerosis
The presentation and distribution of gray matter (GM) and white matter (WM) abnormalities in temporal lobe epilepsy (TLE) have been widely studied. Here, we investigated the GM and WM abnormalities in TLE patients with and without hippocampal sclerosis (HS) in five groups of participants: healthy co...
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Frontiers Media S.A.
2018-03-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fneur.2018.00107/full |
| _version_ | 1819088951798923264 |
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| author | Iman Beheshti Daichi Sone Farnaz Farokhian Farnaz Farokhian Norihide Maikusa Hiroshi Matsuda |
| author_facet | Iman Beheshti Daichi Sone Farnaz Farokhian Farnaz Farokhian Norihide Maikusa Hiroshi Matsuda |
| author_sort | Iman Beheshti |
| collection | DOAJ |
| description | The presentation and distribution of gray matter (GM) and white matter (WM) abnormalities in temporal lobe epilepsy (TLE) have been widely studied. Here, we investigated the GM and WM abnormalities in TLE patients with and without hippocampal sclerosis (HS) in five groups of participants: healthy controls (HCs) (n = 28), right TLE patients with HS (n = 26), right TLE patients without HS (n = 30), left TLE patients with HS (n = 25), and left TLE patients without HS (n = 27). We performed a flexible factorial statistical test in a whole-brain voxel-based morphometry analysis to identify significant GM and WM abnormalities and analysis of variance of hippocampal and amygdala regions among the five groups using the FreeSurfer procedure. Furthermore, we conducted multiple regression analysis to assess regional GM and WM changes with disease duration. We observed significant ipsilateral mesiotemporal GM and WM volume reductions in TLE patients with HS compared with HCs. We also observed a slight GM amygdala swelling in right TLE patients without HS. The regression analysis revealed significant negative GM and WM changes with disease duration specifically in left TLE patients with HS. The observed GM and WM abnormalities may contribute to our understanding of the root of epilepsy mechanisms. |
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| id | doaj.art-4cf41df9119c405cb3d71efb5b9b6d79 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-21T22:00:12Z |
| publishDate | 2018-03-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj.art-4cf41df9119c405cb3d71efb5b9b6d792022-12-21T18:48:51ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-03-01910.3389/fneur.2018.00107303266Gray Matter and White Matter Abnormalities in Temporal Lobe Epilepsy Patients with and without Hippocampal SclerosisIman Beheshti0Daichi Sone1Farnaz Farokhian2Farnaz Farokhian3Norihide Maikusa4Hiroshi Matsuda5Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Kodaira, JapanIntegrative Brain Imaging Center, National Center of Neurology and Psychiatry, Kodaira, JapanIntegrative Brain Imaging Center, National Center of Neurology and Psychiatry, Kodaira, JapanCollege of Life Science and Bioengineering, Beijing University of Technology, Beijing, ChinaIntegrative Brain Imaging Center, National Center of Neurology and Psychiatry, Kodaira, JapanIntegrative Brain Imaging Center, National Center of Neurology and Psychiatry, Kodaira, JapanThe presentation and distribution of gray matter (GM) and white matter (WM) abnormalities in temporal lobe epilepsy (TLE) have been widely studied. Here, we investigated the GM and WM abnormalities in TLE patients with and without hippocampal sclerosis (HS) in five groups of participants: healthy controls (HCs) (n = 28), right TLE patients with HS (n = 26), right TLE patients without HS (n = 30), left TLE patients with HS (n = 25), and left TLE patients without HS (n = 27). We performed a flexible factorial statistical test in a whole-brain voxel-based morphometry analysis to identify significant GM and WM abnormalities and analysis of variance of hippocampal and amygdala regions among the five groups using the FreeSurfer procedure. Furthermore, we conducted multiple regression analysis to assess regional GM and WM changes with disease duration. We observed significant ipsilateral mesiotemporal GM and WM volume reductions in TLE patients with HS compared with HCs. We also observed a slight GM amygdala swelling in right TLE patients without HS. The regression analysis revealed significant negative GM and WM changes with disease duration specifically in left TLE patients with HS. The observed GM and WM abnormalities may contribute to our understanding of the root of epilepsy mechanisms.http://journal.frontiersin.org/article/10.3389/fneur.2018.00107/fulltemporal lobe epilepsyhippocampal sclerosisvoxel-based morphometryFreeSurfermagnetic resonance imaging |
| spellingShingle | Iman Beheshti Daichi Sone Farnaz Farokhian Farnaz Farokhian Norihide Maikusa Hiroshi Matsuda Gray Matter and White Matter Abnormalities in Temporal Lobe Epilepsy Patients with and without Hippocampal Sclerosis Frontiers in Neurology temporal lobe epilepsy hippocampal sclerosis voxel-based morphometry FreeSurfer magnetic resonance imaging |
| title | Gray Matter and White Matter Abnormalities in Temporal Lobe Epilepsy Patients with and without Hippocampal Sclerosis |
| title_full | Gray Matter and White Matter Abnormalities in Temporal Lobe Epilepsy Patients with and without Hippocampal Sclerosis |
| title_fullStr | Gray Matter and White Matter Abnormalities in Temporal Lobe Epilepsy Patients with and without Hippocampal Sclerosis |
| title_full_unstemmed | Gray Matter and White Matter Abnormalities in Temporal Lobe Epilepsy Patients with and without Hippocampal Sclerosis |
| title_short | Gray Matter and White Matter Abnormalities in Temporal Lobe Epilepsy Patients with and without Hippocampal Sclerosis |
| title_sort | gray matter and white matter abnormalities in temporal lobe epilepsy patients with and without hippocampal sclerosis |
| topic | temporal lobe epilepsy hippocampal sclerosis voxel-based morphometry FreeSurfer magnetic resonance imaging |
| url | http://journal.frontiersin.org/article/10.3389/fneur.2018.00107/full |
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