TFPI1 mediates resistance to doxorubicin in breast cancer cells by inducing a hypoxic-like response.

TFPI1 mediates resistance to doxorubicin in breast cancer cells by inducing a hypoxic-like response.

Thrombin and hypoxia are important players in breast cancer progression. Breast cancers often develop drug resistance, but mechanisms linking thrombin and hypoxia to drug resistance remain unresolved. Our studies using Doxorubicin (DOX) resistant MCF7 breast cancer cells reveals a mechanism linking...

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Bibliographic Details
Main Authors: Gerald F Davies, Arnie Berg, Spike D L Postnikoff, Heather L Wilson, Terra G Arnason, Anthony Kusalik, Troy A A Harkness
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3904823?pdf=render

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