Prickle isoforms control the direction of tissue polarity by microtubule independent and dependent mechanisms
Planar cell polarity signaling directs the polarization of cells within the plane of many epithelia. While these tissues exhibit asymmetric localization of a set of core module proteins, in Drosophila, more than one mechanism links the direction of core module polarization to the tissue axes. One si...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
The Company of Biologists
2016-03-01
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| Series: | Biology Open |
| Subjects: | |
| Online Access: | http://bio.biologists.org/content/5/3/229 |
| _version_ | 1818734492747038720 |
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| author | Katherine A. Sharp Jeffrey D. Axelrod |
| author_facet | Katherine A. Sharp Jeffrey D. Axelrod |
| author_sort | Katherine A. Sharp |
| collection | DOAJ |
| description | Planar cell polarity signaling directs the polarization of cells within the plane of many epithelia. While these tissues exhibit asymmetric localization of a set of core module proteins, in Drosophila, more than one mechanism links the direction of core module polarization to the tissue axes. One signaling system establishes a polarity bias in the parallel, apical microtubules upon which vesicles containing core proteins traffic. Swapping expression of the differentially expressed Prickle isoforms, Prickle and Spiny-legs, reverses the direction of core module polarization. Studies in the proximal wing and the anterior abdomen indicated that this results from their differential control of microtubule polarity. Prickle and Spiny-legs also control the direction of polarization in the distal wing (D-wing) and the posterior abdomen (P-abd). We report here that this occurs without affecting microtubule polarity in these tissues. The direction of polarity in the D-wing is therefore likely determined by a novel mechanism independent of microtubule polarity. In the P-abd, Prickle and Spiny-legs interpret at least two directional cues through a microtubule-polarity-independent mechanism. |
| first_indexed | 2024-12-18T00:06:14Z |
| format | Article |
| id | doaj.art-4cf5b44f27884c169b845a65146b247a |
| institution | Directory Open Access Journal |
| issn | 2046-6390 |
| language | English |
| last_indexed | 2024-12-18T00:06:14Z |
| publishDate | 2016-03-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Biology Open |
| spelling | doaj.art-4cf5b44f27884c169b845a65146b247a2022-12-21T21:27:48ZengThe Company of BiologistsBiology Open2046-63902016-03-015322923610.1242/bio.016162016162Prickle isoforms control the direction of tissue polarity by microtubule independent and dependent mechanismsKatherine A. Sharp0Jeffrey D. Axelrod1 Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, L235, Stanford, CA 94305, USA Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, L235, Stanford, CA 94305, USA Planar cell polarity signaling directs the polarization of cells within the plane of many epithelia. While these tissues exhibit asymmetric localization of a set of core module proteins, in Drosophila, more than one mechanism links the direction of core module polarization to the tissue axes. One signaling system establishes a polarity bias in the parallel, apical microtubules upon which vesicles containing core proteins traffic. Swapping expression of the differentially expressed Prickle isoforms, Prickle and Spiny-legs, reverses the direction of core module polarization. Studies in the proximal wing and the anterior abdomen indicated that this results from their differential control of microtubule polarity. Prickle and Spiny-legs also control the direction of polarization in the distal wing (D-wing) and the posterior abdomen (P-abd). We report here that this occurs without affecting microtubule polarity in these tissues. The direction of polarity in the D-wing is therefore likely determined by a novel mechanism independent of microtubule polarity. In the P-abd, Prickle and Spiny-legs interpret at least two directional cues through a microtubule-polarity-independent mechanism.http://bio.biologists.org/content/5/3/229Planar cell polarityPrickleSpiny-legsDrosophilaFat |
| spellingShingle | Katherine A. Sharp Jeffrey D. Axelrod Prickle isoforms control the direction of tissue polarity by microtubule independent and dependent mechanisms Biology Open Planar cell polarity Prickle Spiny-legs Drosophila Fat |
| title | Prickle isoforms control the direction of tissue polarity by microtubule independent and dependent mechanisms |
| title_full | Prickle isoforms control the direction of tissue polarity by microtubule independent and dependent mechanisms |
| title_fullStr | Prickle isoforms control the direction of tissue polarity by microtubule independent and dependent mechanisms |
| title_full_unstemmed | Prickle isoforms control the direction of tissue polarity by microtubule independent and dependent mechanisms |
| title_short | Prickle isoforms control the direction of tissue polarity by microtubule independent and dependent mechanisms |
| title_sort | prickle isoforms control the direction of tissue polarity by microtubule independent and dependent mechanisms |
| topic | Planar cell polarity Prickle Spiny-legs Drosophila Fat |
| url | http://bio.biologists.org/content/5/3/229 |
| work_keys_str_mv | AT katherineasharp prickleisoformscontrolthedirectionoftissuepolaritybymicrotubuleindependentanddependentmechanisms AT jeffreydaxelrod prickleisoformscontrolthedirectionoftissuepolaritybymicrotubuleindependentanddependentmechanisms |