Preterm birth and weight-for-gestational age for risks of autism spectrum disorder and intellectual disability: A nationwide population-based cohort study
Purpose: To evaluate gestational age (GA) and small-for-gestational age (SGA) as continuums and gender on the incidences of autism spectrum disorder (ASD) and co-occurring intellectual disability (ID). Methods: This is a population-based cohort study using the 2004–2008 Taiwan Maternal and Child Hea...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664622003898 |
| _version_ | 1797823345682546688 |
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| author | Yu-Shan Chang Li-Wen Chen Tsung Yu Sheng-Hsiang Lin Pao-Lin Kuo |
| author_facet | Yu-Shan Chang Li-Wen Chen Tsung Yu Sheng-Hsiang Lin Pao-Lin Kuo |
| author_sort | Yu-Shan Chang |
| collection | DOAJ |
| description | Purpose: To evaluate gestational age (GA) and small-for-gestational age (SGA) as continuums and gender on the incidences of autism spectrum disorder (ASD) and co-occurring intellectual disability (ID). Methods: This is a population-based cohort study using the 2004–2008 Taiwan Maternal and Child Health Database. The diagnosis of ASD was determined by International Classification of Diseases, 9th Revision (ICD-9). Generalized estimating equations models were fit to evaluate associations between perinatal variables and ASD. Results: This study included 916,315 individuals. A total of 9474 (1.0%) children were diagnosed with ASD, among whom 1594 (16.8%) had co-occurring ID. Lower GA carried higher odds of ASD with ID (GA < 28 weeks, aOR: 4.26, 95% CI: 2.13, 8.50; GA 28–30 weeks, aOR: 2.80, 95% CI: 1.57, 4.97; GA 31–33 weeks, aOR: 1.63, 95% CI: 1.05, 2.55; GA 34–36 weeks, aOR: 1.39, 95% CI: 1.16, 1.67) and ASD without ID (GA < 28 weeks, aOR:2.05, 95% CI: 1.25, 3.36; GA 28–30 weeks, aOR: 2.02, 95% CI: 1.46, 2.79; GA 31–33 weeks, aOR: 1.42, 95% CI: 1.13, 1.77; GA 34–36 weeks, aOR: 1.18, 95% CI: 1.08, 1.29). Male preterm infants had ASD risks negatively correlated to GA, while ASD risks were significantly increased only among female infants born late preterm. The degree of SGA showed a stepwise increased risk for ASD with and without ID in both male and female infants. Conclusion: Lower GA and the degree of SGA are both associated with ASD susceptibility, either with or without co-occurring ID, and remarkably increased the risk of ID. |
| first_indexed | 2024-03-13T10:22:44Z |
| format | Article |
| id | doaj.art-4cf6a35d3bed49b6b71552148e6a744b |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-03-13T10:22:44Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-4cf6a35d3bed49b6b71552148e6a744b2023-05-20T04:29:27ZengElsevierJournal of the Formosan Medical Association0929-66462023-06-011226493504Preterm birth and weight-for-gestational age for risks of autism spectrum disorder and intellectual disability: A nationwide population-based cohort studyYu-Shan Chang0Li-Wen Chen1Tsung Yu2Sheng-Hsiang Lin3Pao-Lin Kuo4Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROCDepartment of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Public Health, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC; Department of Public Health, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Biostatistics Consulting Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Corresponding author. 138 Sheng-Li Road, Tainan 704, Taiwan. Fax: +886 6 2758781.Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Corresponding author. 138 Sheng-Li Road, Tainan 704, Taiwan. Fax: +886 6 2766185.Purpose: To evaluate gestational age (GA) and small-for-gestational age (SGA) as continuums and gender on the incidences of autism spectrum disorder (ASD) and co-occurring intellectual disability (ID). Methods: This is a population-based cohort study using the 2004–2008 Taiwan Maternal and Child Health Database. The diagnosis of ASD was determined by International Classification of Diseases, 9th Revision (ICD-9). Generalized estimating equations models were fit to evaluate associations between perinatal variables and ASD. Results: This study included 916,315 individuals. A total of 9474 (1.0%) children were diagnosed with ASD, among whom 1594 (16.8%) had co-occurring ID. Lower GA carried higher odds of ASD with ID (GA < 28 weeks, aOR: 4.26, 95% CI: 2.13, 8.50; GA 28–30 weeks, aOR: 2.80, 95% CI: 1.57, 4.97; GA 31–33 weeks, aOR: 1.63, 95% CI: 1.05, 2.55; GA 34–36 weeks, aOR: 1.39, 95% CI: 1.16, 1.67) and ASD without ID (GA < 28 weeks, aOR:2.05, 95% CI: 1.25, 3.36; GA 28–30 weeks, aOR: 2.02, 95% CI: 1.46, 2.79; GA 31–33 weeks, aOR: 1.42, 95% CI: 1.13, 1.77; GA 34–36 weeks, aOR: 1.18, 95% CI: 1.08, 1.29). Male preterm infants had ASD risks negatively correlated to GA, while ASD risks were significantly increased only among female infants born late preterm. The degree of SGA showed a stepwise increased risk for ASD with and without ID in both male and female infants. Conclusion: Lower GA and the degree of SGA are both associated with ASD susceptibility, either with or without co-occurring ID, and remarkably increased the risk of ID.http://www.sciencedirect.com/science/article/pii/S0929664622003898Autism spectrum disorderGestational ageIntellectual disabilityPrematureSex factors |
| spellingShingle | Yu-Shan Chang Li-Wen Chen Tsung Yu Sheng-Hsiang Lin Pao-Lin Kuo Preterm birth and weight-for-gestational age for risks of autism spectrum disorder and intellectual disability: A nationwide population-based cohort study Journal of the Formosan Medical Association Autism spectrum disorder Gestational age Intellectual disability Premature Sex factors |
| title | Preterm birth and weight-for-gestational age for risks of autism spectrum disorder and intellectual disability: A nationwide population-based cohort study |
| title_full | Preterm birth and weight-for-gestational age for risks of autism spectrum disorder and intellectual disability: A nationwide population-based cohort study |
| title_fullStr | Preterm birth and weight-for-gestational age for risks of autism spectrum disorder and intellectual disability: A nationwide population-based cohort study |
| title_full_unstemmed | Preterm birth and weight-for-gestational age for risks of autism spectrum disorder and intellectual disability: A nationwide population-based cohort study |
| title_short | Preterm birth and weight-for-gestational age for risks of autism spectrum disorder and intellectual disability: A nationwide population-based cohort study |
| title_sort | preterm birth and weight for gestational age for risks of autism spectrum disorder and intellectual disability a nationwide population based cohort study |
| topic | Autism spectrum disorder Gestational age Intellectual disability Premature Sex factors |
| url | http://www.sciencedirect.com/science/article/pii/S0929664622003898 |
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