Preparation of a number of 4,3,1-oxadiazole substituted derived from imidazole and evaluation of their biological effectiveness
<strong>ABSTRACT</strong><br /> Ethyl 2-(1H-imidazol-1-yl)acetate (A<sub>1</sub>) was synthesized by the reaction of ethylchloroacetate with imidazol, Then refluxed with hydrazine hydrate to obtain 2-(1H-imidazol-1-yl)acidhydrazid (A<sub>2</sub>) ....
| Main Authors: | , , |
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| Format: | Article |
| Language: | Arabic |
| Published: |
College of Education for Pure Sciences
2013-12-01
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| Series: | مجلة التربية والعلم |
| Subjects: | |
| Online Access: | https://edusj.mosuljournals.com/article_163107_600a730b6b2fa44633455144565199c2.pdf |
| Summary: | <strong>ABSTRACT</strong><br /> Ethyl 2-(1H-imidazol-1-yl)acetate (A<sub>1</sub>) was synthesized by the reaction of ethylchloroacetate with imidazol, Then refluxed with hydrazine hydrate to obtain 2-(1H-imidazol-1-yl)acidhydrazid (A<sub>2</sub>) . (A<sub>2</sub>) was reaction with various substituted benzyldehyd to gain 6 novel compounds shiffe bases(A<sub>3-8</sub>).and 5-(1H-imidazol-1-yl)methyl)3-N-acetyl-2-(aryl)-1,3,4-(2H)-Oxadiazol (A<sub>9-12</sub>) were synthesized by the reaction of shiffe bases(A<sub>3-8</sub>)with acetic anhydride . In order to show the antibacterial activity of prepared compounds are evaluated against four types of common bacteria (<em>psedomonus, Staphylococcus aureus, Eschershia coli, Klebsiella peneuomina</em>). The result of biological study are compared with standered antibiotic (metheprem & Gentamycin) . The structure of the synthesized compounds are confirmed by I.R, <sup>1</sup>H-NMR & <sup>13</sup>C-NMR spectra and Some chemical physical data. |
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| ISSN: | 1812-125X 2664-2530 |