Preparation of a number of 4,3,1-oxadiazole substituted derived from imidazole and evaluation of their biological effectiveness

<strong>ABSTRACT</strong><br />          Ethyl 2-(1H-imidazol-1-yl)acetate (A<sub>1</sub>)  was synthesized by the reaction of ethylchloroacetate with imidazol, Then refluxed with hydrazine hydrate to obtain 2-(1H-imidazol-1-yl)acidhydrazid (A<sub>2</sub>) ....

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Main Authors: Khaled Al Badrani, Khalid Al-Janabi, Ammar Saad Eddin
Format: Article
Language:Arabic
Published: College of Education for Pure Sciences 2013-12-01
Series:مجلة التربية والعلم
Subjects:
Online Access:https://edusj.mosuljournals.com/article_163107_600a730b6b2fa44633455144565199c2.pdf
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author Khaled Al Badrani
Khalid Al-Janabi
Ammar Saad Eddin
author_facet Khaled Al Badrani
Khalid Al-Janabi
Ammar Saad Eddin
author_sort Khaled Al Badrani
collection DOAJ
description <strong>ABSTRACT</strong><br />          Ethyl 2-(1H-imidazol-1-yl)acetate (A<sub>1</sub>)  was synthesized by the reaction of ethylchloroacetate with imidazol, Then refluxed with hydrazine hydrate to obtain 2-(1H-imidazol-1-yl)acidhydrazid (A<sub>2</sub>) . (A<sub>2</sub>)  was reaction  with various substituted benzyldehyd  to gain 6 novel compounds shiffe bases(A<sub>3-8</sub>).and 5-(1H-imidazol-1-yl)methyl)3-N-acetyl-2-(aryl)-1,3,4-(2H)-Oxadiazol (A<sub>9-12</sub>) were synthesized by the reaction of shiffe bases(A<sub>3-8</sub>)with acetic anhydride . In order to show the antibacterial  activity of prepared compounds are evaluated against four types of common bacteria (<em>psedomonus, Staphylococcus aureus, Eschershia coli, Klebsiella peneuomina</em>). The result of biological study are compared with standered antibiotic (metheprem & Gentamycin) . The structure of the synthesized compounds are confirmed by I.R, <sup>1</sup>H-NMR & <sup>13</sup>C-NMR spectra and Some chemical physical data.
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spelling doaj.art-4cf88d1e079b46c28c78bb166eb0165d2022-12-21T20:18:17ZaraCollege of Education for Pure Sciencesمجلة التربية والعلم1812-125X2664-25302013-12-0126530631310.33899/edusj.2013.163107163107Preparation of a number of 4,3,1-oxadiazole substituted derived from imidazole and evaluation of their biological effectivenessKhaled Al Badrani0Khalid Al-Janabi1Ammar Saad Eddin2Department of Food Science / College of Agriculture / University of TikritDepartment of Chemistry / College of Education / University of TikritDepartment of Chemistry / College of Science / University of Kirkuk<strong>ABSTRACT</strong><br />          Ethyl 2-(1H-imidazol-1-yl)acetate (A<sub>1</sub>)  was synthesized by the reaction of ethylchloroacetate with imidazol, Then refluxed with hydrazine hydrate to obtain 2-(1H-imidazol-1-yl)acidhydrazid (A<sub>2</sub>) . (A<sub>2</sub>)  was reaction  with various substituted benzyldehyd  to gain 6 novel compounds shiffe bases(A<sub>3-8</sub>).and 5-(1H-imidazol-1-yl)methyl)3-N-acetyl-2-(aryl)-1,3,4-(2H)-Oxadiazol (A<sub>9-12</sub>) were synthesized by the reaction of shiffe bases(A<sub>3-8</sub>)with acetic anhydride . In order to show the antibacterial  activity of prepared compounds are evaluated against four types of common bacteria (<em>psedomonus, Staphylococcus aureus, Eschershia coli, Klebsiella peneuomina</em>). The result of biological study are compared with standered antibiotic (metheprem & Gentamycin) . The structure of the synthesized compounds are confirmed by I.R, <sup>1</sup>H-NMR & <sup>13</sup>C-NMR spectra and Some chemical physical data.https://edusj.mosuljournals.com/article_163107_600a730b6b2fa44633455144565199c2.pdf431-oxadiazole derivativesamidazolebiological effectiveness
spellingShingle Khaled Al Badrani
Khalid Al-Janabi
Ammar Saad Eddin
Preparation of a number of 4,3,1-oxadiazole substituted derived from imidazole and evaluation of their biological effectiveness
مجلة التربية والعلم
4
3
1-oxadiazole derivatives
amidazole
biological effectiveness
title Preparation of a number of 4,3,1-oxadiazole substituted derived from imidazole and evaluation of their biological effectiveness
title_full Preparation of a number of 4,3,1-oxadiazole substituted derived from imidazole and evaluation of their biological effectiveness
title_fullStr Preparation of a number of 4,3,1-oxadiazole substituted derived from imidazole and evaluation of their biological effectiveness
title_full_unstemmed Preparation of a number of 4,3,1-oxadiazole substituted derived from imidazole and evaluation of their biological effectiveness
title_short Preparation of a number of 4,3,1-oxadiazole substituted derived from imidazole and evaluation of their biological effectiveness
title_sort preparation of a number of 4 3 1 oxadiazole substituted derived from imidazole and evaluation of their biological effectiveness
topic 4
3
1-oxadiazole derivatives
amidazole
biological effectiveness
url https://edusj.mosuljournals.com/article_163107_600a730b6b2fa44633455144565199c2.pdf
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AT khalidaljanabi preparationofanumberof431oxadiazolesubstitutedderivedfromimidazoleandevaluationoftheirbiologicaleffectiveness
AT ammarsaadeddin preparationofanumberof431oxadiazolesubstitutedderivedfromimidazoleandevaluationoftheirbiologicaleffectiveness