Preparation of a number of 4,3,1-oxadiazole substituted derived from imidazole and evaluation of their biological effectiveness
<strong>ABSTRACT</strong><br /> Ethyl 2-(1H-imidazol-1-yl)acetate (A<sub>1</sub>) was synthesized by the reaction of ethylchloroacetate with imidazol, Then refluxed with hydrazine hydrate to obtain 2-(1H-imidazol-1-yl)acidhydrazid (A<sub>2</sub>) ....
Main Authors: | , , |
---|---|
Format: | Article |
Language: | Arabic |
Published: |
College of Education for Pure Sciences
2013-12-01
|
Series: | مجلة التربية والعلم |
Subjects: | |
Online Access: | https://edusj.mosuljournals.com/article_163107_600a730b6b2fa44633455144565199c2.pdf |
_version_ | 1818877985475788800 |
---|---|
author | Khaled Al Badrani Khalid Al-Janabi Ammar Saad Eddin |
author_facet | Khaled Al Badrani Khalid Al-Janabi Ammar Saad Eddin |
author_sort | Khaled Al Badrani |
collection | DOAJ |
description | <strong>ABSTRACT</strong><br /> Ethyl 2-(1H-imidazol-1-yl)acetate (A<sub>1</sub>) was synthesized by the reaction of ethylchloroacetate with imidazol, Then refluxed with hydrazine hydrate to obtain 2-(1H-imidazol-1-yl)acidhydrazid (A<sub>2</sub>) . (A<sub>2</sub>) was reaction with various substituted benzyldehyd to gain 6 novel compounds shiffe bases(A<sub>3-8</sub>).and 5-(1H-imidazol-1-yl)methyl)3-N-acetyl-2-(aryl)-1,3,4-(2H)-Oxadiazol (A<sub>9-12</sub>) were synthesized by the reaction of shiffe bases(A<sub>3-8</sub>)with acetic anhydride . In order to show the antibacterial activity of prepared compounds are evaluated against four types of common bacteria (<em>psedomonus, Staphylococcus aureus, Eschershia coli, Klebsiella peneuomina</em>). The result of biological study are compared with standered antibiotic (metheprem & Gentamycin) . The structure of the synthesized compounds are confirmed by I.R, <sup>1</sup>H-NMR & <sup>13</sup>C-NMR spectra and Some chemical physical data. |
first_indexed | 2024-12-19T14:06:59Z |
format | Article |
id | doaj.art-4cf88d1e079b46c28c78bb166eb0165d |
institution | Directory Open Access Journal |
issn | 1812-125X 2664-2530 |
language | Arabic |
last_indexed | 2024-12-19T14:06:59Z |
publishDate | 2013-12-01 |
publisher | College of Education for Pure Sciences |
record_format | Article |
series | مجلة التربية والعلم |
spelling | doaj.art-4cf88d1e079b46c28c78bb166eb0165d2022-12-21T20:18:17ZaraCollege of Education for Pure Sciencesمجلة التربية والعلم1812-125X2664-25302013-12-0126530631310.33899/edusj.2013.163107163107Preparation of a number of 4,3,1-oxadiazole substituted derived from imidazole and evaluation of their biological effectivenessKhaled Al Badrani0Khalid Al-Janabi1Ammar Saad Eddin2Department of Food Science / College of Agriculture / University of TikritDepartment of Chemistry / College of Education / University of TikritDepartment of Chemistry / College of Science / University of Kirkuk<strong>ABSTRACT</strong><br /> Ethyl 2-(1H-imidazol-1-yl)acetate (A<sub>1</sub>) was synthesized by the reaction of ethylchloroacetate with imidazol, Then refluxed with hydrazine hydrate to obtain 2-(1H-imidazol-1-yl)acidhydrazid (A<sub>2</sub>) . (A<sub>2</sub>) was reaction with various substituted benzyldehyd to gain 6 novel compounds shiffe bases(A<sub>3-8</sub>).and 5-(1H-imidazol-1-yl)methyl)3-N-acetyl-2-(aryl)-1,3,4-(2H)-Oxadiazol (A<sub>9-12</sub>) were synthesized by the reaction of shiffe bases(A<sub>3-8</sub>)with acetic anhydride . In order to show the antibacterial activity of prepared compounds are evaluated against four types of common bacteria (<em>psedomonus, Staphylococcus aureus, Eschershia coli, Klebsiella peneuomina</em>). The result of biological study are compared with standered antibiotic (metheprem & Gentamycin) . The structure of the synthesized compounds are confirmed by I.R, <sup>1</sup>H-NMR & <sup>13</sup>C-NMR spectra and Some chemical physical data.https://edusj.mosuljournals.com/article_163107_600a730b6b2fa44633455144565199c2.pdf431-oxadiazole derivativesamidazolebiological effectiveness |
spellingShingle | Khaled Al Badrani Khalid Al-Janabi Ammar Saad Eddin Preparation of a number of 4,3,1-oxadiazole substituted derived from imidazole and evaluation of their biological effectiveness مجلة التربية والعلم 4 3 1-oxadiazole derivatives amidazole biological effectiveness |
title | Preparation of a number of 4,3,1-oxadiazole substituted derived from imidazole and evaluation of their biological effectiveness |
title_full | Preparation of a number of 4,3,1-oxadiazole substituted derived from imidazole and evaluation of their biological effectiveness |
title_fullStr | Preparation of a number of 4,3,1-oxadiazole substituted derived from imidazole and evaluation of their biological effectiveness |
title_full_unstemmed | Preparation of a number of 4,3,1-oxadiazole substituted derived from imidazole and evaluation of their biological effectiveness |
title_short | Preparation of a number of 4,3,1-oxadiazole substituted derived from imidazole and evaluation of their biological effectiveness |
title_sort | preparation of a number of 4 3 1 oxadiazole substituted derived from imidazole and evaluation of their biological effectiveness |
topic | 4 3 1-oxadiazole derivatives amidazole biological effectiveness |
url | https://edusj.mosuljournals.com/article_163107_600a730b6b2fa44633455144565199c2.pdf |
work_keys_str_mv | AT khaledalbadrani preparationofanumberof431oxadiazolesubstitutedderivedfromimidazoleandevaluationoftheirbiologicaleffectiveness AT khalidaljanabi preparationofanumberof431oxadiazolesubstitutedderivedfromimidazoleandevaluationoftheirbiologicaleffectiveness AT ammarsaadeddin preparationofanumberof431oxadiazolesubstitutedderivedfromimidazoleandevaluationoftheirbiologicaleffectiveness |