Local brain-state dependency of effective connectivity: a pilot TMS–EEG study [version 2; peer review: 2 approved]
Background Spontaneous cortical oscillations have been shown to modulate cortical responses to transcranial magnetic stimulation (TMS). However, whether these oscillations influence cortical effective connectivity is largely unknown. We conducted a pilot study to set the basis for addressing how spo...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2022-07-01
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| Series: | Open Research Europe |
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| Online Access: | https://open-research-europe.ec.europa.eu/articles/2-45/v2 |
| _version_ | 1811309292729401344 |
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| author | Matteo Fecchio Victor H. Souza Pantelis Lioumis Mario Rosanova Risto J. Ilmoniemi Tuomas P. Mutanen Ida Granö Jaakko O. Nieminen Aino Tervo |
| author_facet | Matteo Fecchio Victor H. Souza Pantelis Lioumis Mario Rosanova Risto J. Ilmoniemi Tuomas P. Mutanen Ida Granö Jaakko O. Nieminen Aino Tervo |
| author_sort | Matteo Fecchio |
| collection | DOAJ |
| description | Background Spontaneous cortical oscillations have been shown to modulate cortical responses to transcranial magnetic stimulation (TMS). However, whether these oscillations influence cortical effective connectivity is largely unknown. We conducted a pilot study to set the basis for addressing how spontaneous oscillations affect cortical effective connectivity measured through TMS-evoked potentials (TEPs). Methods We applied TMS to the left primary motor cortex and right pre-supplementary motor area of three subjects while recording EEG. We classified trials off-line into positive- and negative-phase classes according to the mu and beta rhythms. We calculated differences in the global mean-field amplitude (GMFA) and compared the cortical spreading of the TMS-evoked activity between the two classes. Results Phase affected the GMFA in four out of 12 datasets (3 subjects × 2 stimulation sites × 2 frequency bands). Two of the observed significant intervals were before 50 ms, two between 50 and 100 ms, and one after 100 ms post-stimulus. Source estimates showed complex spatial differences between the classes in the cortical spreading of the TMS-evoked activity. Conclusions TMS-evoked effective connectivity seems to depend on the phase of local cortical oscillations at the stimulated site. This work paves the way to design future closed-loop stimulation paradigms. |
| first_indexed | 2024-04-13T09:39:44Z |
| format | Article |
| id | doaj.art-4cfa77ed99aa4f77971590a097b075f7 |
| institution | Directory Open Access Journal |
| issn | 2732-5121 |
| language | English |
| last_indexed | 2024-04-13T09:39:44Z |
| publishDate | 2022-07-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | Open Research Europe |
| spelling | doaj.art-4cfa77ed99aa4f77971590a097b075f72022-12-22T02:51:59ZengF1000 Research LtdOpen Research Europe2732-51212022-07-01216165Local brain-state dependency of effective connectivity: a pilot TMS–EEG study [version 2; peer review: 2 approved]Matteo Fecchio0https://orcid.org/0000-0002-0347-8531Victor H. Souza1https://orcid.org/0000-0002-0254-4322Pantelis Lioumis2https://orcid.org/0000-0003-2016-9199Mario Rosanova3Risto J. Ilmoniemi4Tuomas P. Mutanen5Ida Granö6https://orcid.org/0000-0003-4646-0419Jaakko O. Nieminen7Aino Tervo8Department of Biomedical and Clinical Sciences “L. Sacco”, University of Milan, Milan, ItalyDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, FinlandDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, FinlandDepartment of Biomedical and Clinical Sciences “L. Sacco”, University of Milan, Milan, ItalyDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, FinlandDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, FinlandDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, FinlandDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, FinlandDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, FinlandBackground Spontaneous cortical oscillations have been shown to modulate cortical responses to transcranial magnetic stimulation (TMS). However, whether these oscillations influence cortical effective connectivity is largely unknown. We conducted a pilot study to set the basis for addressing how spontaneous oscillations affect cortical effective connectivity measured through TMS-evoked potentials (TEPs). Methods We applied TMS to the left primary motor cortex and right pre-supplementary motor area of three subjects while recording EEG. We classified trials off-line into positive- and negative-phase classes according to the mu and beta rhythms. We calculated differences in the global mean-field amplitude (GMFA) and compared the cortical spreading of the TMS-evoked activity between the two classes. Results Phase affected the GMFA in four out of 12 datasets (3 subjects × 2 stimulation sites × 2 frequency bands). Two of the observed significant intervals were before 50 ms, two between 50 and 100 ms, and one after 100 ms post-stimulus. Source estimates showed complex spatial differences between the classes in the cortical spreading of the TMS-evoked activity. Conclusions TMS-evoked effective connectivity seems to depend on the phase of local cortical oscillations at the stimulated site. This work paves the way to design future closed-loop stimulation paradigms.https://open-research-europe.ec.europa.eu/articles/2-45/v2Transcranial magnetic stimulation; electroencephalography; brain state; effective connectivityeng |
| spellingShingle | Matteo Fecchio Victor H. Souza Pantelis Lioumis Mario Rosanova Risto J. Ilmoniemi Tuomas P. Mutanen Ida Granö Jaakko O. Nieminen Aino Tervo Local brain-state dependency of effective connectivity: a pilot TMS–EEG study [version 2; peer review: 2 approved] Open Research Europe Transcranial magnetic stimulation; electroencephalography; brain state; effective connectivity eng |
| title | Local brain-state dependency of effective connectivity: a pilot TMS–EEG study [version 2; peer review: 2 approved] |
| title_full | Local brain-state dependency of effective connectivity: a pilot TMS–EEG study [version 2; peer review: 2 approved] |
| title_fullStr | Local brain-state dependency of effective connectivity: a pilot TMS–EEG study [version 2; peer review: 2 approved] |
| title_full_unstemmed | Local brain-state dependency of effective connectivity: a pilot TMS–EEG study [version 2; peer review: 2 approved] |
| title_short | Local brain-state dependency of effective connectivity: a pilot TMS–EEG study [version 2; peer review: 2 approved] |
| title_sort | local brain state dependency of effective connectivity a pilot tms eeg study version 2 peer review 2 approved |
| topic | Transcranial magnetic stimulation; electroencephalography; brain state; effective connectivity eng |
| url | https://open-research-europe.ec.europa.eu/articles/2-45/v2 |
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