Epidemiology and molecular characterization of multidrug-resistant Gram-negative bacteria in Southeast Asia
Abstract Background Multidrug-resistant Gram-negative bacteria (MDRGN), including extended-spectrum β-lactamases (ESBLs) and multidrug-resistant glucose-nonfermenting Gram-negative bacilli (nonfermenters), have emerged and spread throughout Southeast Asia. Methods We reviewed and summarized current...
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| Format: | Article |
| Language: | English |
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BMC
2016-05-01
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| Series: | Antimicrobial Resistance and Infection Control |
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| Online Access: | http://link.springer.com/article/10.1186/s13756-016-0115-6 |
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| author | Nuntra Suwantarat Karen C. Carroll |
| author_facet | Nuntra Suwantarat Karen C. Carroll |
| author_sort | Nuntra Suwantarat |
| collection | DOAJ |
| description | Abstract Background Multidrug-resistant Gram-negative bacteria (MDRGN), including extended-spectrum β-lactamases (ESBLs) and multidrug-resistant glucose-nonfermenting Gram-negative bacilli (nonfermenters), have emerged and spread throughout Southeast Asia. Methods We reviewed and summarized current critical knowledge on the epidemiology and molecular characterization of MDRGN in Southeast Asia by PubMed searches for publications prior to 10 March 2016 with the term related to “MDRGN definition” combined with specific Southeast Asian country names (Thailand, Singapore, Malaysia, Vietnam, Indonesia, Philippines, Laos, Cambodia, Myanmar, Brunei). Results There were a total of 175 publications from the following countries: Thailand (77), Singapore (35), Malaysia (32), Vietnam (23), Indonesia (6), Philippines (1), Laos (1), and Brunei (1). We did not find any publications on MDRGN from Myanmar and Cambodia. We did not include publications related to Shigella spp., Salmonella spp., and Vibrio spp. and non-human related studies in our review. English language articles and abstracts were included for analysis. After the abstracts were reviewed, data on MDRGN in Southeast Asia from 54 publications were further reviewed and included in this study. Conclusions MDRGNs are a major contributor of antimicrobial-resistant bacteria in Southeast Asia. The high prevalence of ESBLs has been a major problem since 2005 and is possibly related to the development of carbapenem resistant organisms in this region due to the overuse of carbapenem therapy. Carbapenem–resistant Acinetobacter baumannii is the most common pathogen associated with nosocomial infections in this region followed by carbapenem-resistant Pseudomonas aeruginosa. Although Southeast Asia is not an endemic area for carbapenem-resistant Enterobacteriaceae (CRE), recently, the rate of CRE detection has been increasing. Limited infection control measures, lack of antimicrobial control, such as the presence of active antimicrobial stewardship teams in the hospital, and outpatient antibiotic restrictions, and travel throughout this region have likely contributed to the increase in MDRGN prevalence. |
| first_indexed | 2024-04-12T02:12:19Z |
| format | Article |
| id | doaj.art-4cfbdcb6e5af4a09a30e52c09cbf8065 |
| institution | Directory Open Access Journal |
| issn | 2047-2994 |
| language | English |
| last_indexed | 2024-04-12T02:12:19Z |
| publishDate | 2016-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Antimicrobial Resistance and Infection Control |
| spelling | doaj.art-4cfbdcb6e5af4a09a30e52c09cbf80652022-12-22T03:52:22ZengBMCAntimicrobial Resistance and Infection Control2047-29942016-05-01511810.1186/s13756-016-0115-6Epidemiology and molecular characterization of multidrug-resistant Gram-negative bacteria in Southeast AsiaNuntra Suwantarat0Karen C. Carroll1Chulabhorn International College of Medicine, Thammasat UniversityDivision of Medical Microbiology, Johns Hopkins University School of MedicineAbstract Background Multidrug-resistant Gram-negative bacteria (MDRGN), including extended-spectrum β-lactamases (ESBLs) and multidrug-resistant glucose-nonfermenting Gram-negative bacilli (nonfermenters), have emerged and spread throughout Southeast Asia. Methods We reviewed and summarized current critical knowledge on the epidemiology and molecular characterization of MDRGN in Southeast Asia by PubMed searches for publications prior to 10 March 2016 with the term related to “MDRGN definition” combined with specific Southeast Asian country names (Thailand, Singapore, Malaysia, Vietnam, Indonesia, Philippines, Laos, Cambodia, Myanmar, Brunei). Results There were a total of 175 publications from the following countries: Thailand (77), Singapore (35), Malaysia (32), Vietnam (23), Indonesia (6), Philippines (1), Laos (1), and Brunei (1). We did not find any publications on MDRGN from Myanmar and Cambodia. We did not include publications related to Shigella spp., Salmonella spp., and Vibrio spp. and non-human related studies in our review. English language articles and abstracts were included for analysis. After the abstracts were reviewed, data on MDRGN in Southeast Asia from 54 publications were further reviewed and included in this study. Conclusions MDRGNs are a major contributor of antimicrobial-resistant bacteria in Southeast Asia. The high prevalence of ESBLs has been a major problem since 2005 and is possibly related to the development of carbapenem resistant organisms in this region due to the overuse of carbapenem therapy. Carbapenem–resistant Acinetobacter baumannii is the most common pathogen associated with nosocomial infections in this region followed by carbapenem-resistant Pseudomonas aeruginosa. Although Southeast Asia is not an endemic area for carbapenem-resistant Enterobacteriaceae (CRE), recently, the rate of CRE detection has been increasing. Limited infection control measures, lack of antimicrobial control, such as the presence of active antimicrobial stewardship teams in the hospital, and outpatient antibiotic restrictions, and travel throughout this region have likely contributed to the increase in MDRGN prevalence.http://link.springer.com/article/10.1186/s13756-016-0115-6Gram-negative bacteriaMultidrug-resistanceSoutheast AsiaMolecularEpidemiology |
| spellingShingle | Nuntra Suwantarat Karen C. Carroll Epidemiology and molecular characterization of multidrug-resistant Gram-negative bacteria in Southeast Asia Antimicrobial Resistance and Infection Control Gram-negative bacteria Multidrug-resistance Southeast Asia Molecular Epidemiology |
| title | Epidemiology and molecular characterization of multidrug-resistant Gram-negative bacteria in Southeast Asia |
| title_full | Epidemiology and molecular characterization of multidrug-resistant Gram-negative bacteria in Southeast Asia |
| title_fullStr | Epidemiology and molecular characterization of multidrug-resistant Gram-negative bacteria in Southeast Asia |
| title_full_unstemmed | Epidemiology and molecular characterization of multidrug-resistant Gram-negative bacteria in Southeast Asia |
| title_short | Epidemiology and molecular characterization of multidrug-resistant Gram-negative bacteria in Southeast Asia |
| title_sort | epidemiology and molecular characterization of multidrug resistant gram negative bacteria in southeast asia |
| topic | Gram-negative bacteria Multidrug-resistance Southeast Asia Molecular Epidemiology |
| url | http://link.springer.com/article/10.1186/s13756-016-0115-6 |
| work_keys_str_mv | AT nuntrasuwantarat epidemiologyandmolecularcharacterizationofmultidrugresistantgramnegativebacteriainsoutheastasia AT karenccarroll epidemiologyandmolecularcharacterizationofmultidrugresistantgramnegativebacteriainsoutheastasia |