Irreversible electroporation promotes a pro-inflammatory tumor microenvironment and anti-tumor immunity in a mouse pancreatic cancer model

Irreversible electroporation promotes a pro-inflammatory tumor microenvironment and anti-tumor immunity in a mouse pancreatic cancer model

Pancreatic cancer is a significant cause of cancer-related mortality and often presents with limited treatment options. Pancreatic tumors are also notorious for their immunosuppressive microenvironment. Irreversible electroporation (IRE) is a non-thermal tumor ablation modality that employs high-vol...

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Bibliographic Details
Main Authors: Khan Mohammad Imran, Rebecca M. Brock, Natalie Beitel-White, Manali Powar, Katie Orr, Kenneth N. Aycock, Nastaran Alinezhadbalalami, Zaid S. Salameh, Paige Eversole, Benjamin Tintera, Justin Markov Madanick, Alissa Hendricks-Wenger, Sheryl Coutermarsh-Ott, Rafael V. Davalos, Irving C. Allen
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
ire
tumor ablation
immunomodulation
tumor recurrence
cell cycle arrest
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1352821/full

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