Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature
In this review, we have gathered and analyzed the available genetic evidence on the association between the methylenetetrahydrofolate reductase gene (<i>MTHFR</i>), rs1801133 and the risk of Hypertension (HTN) in African populations, which was further compared to the global data evidence...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/4/631 |
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| author | Sihle E. Mabhida Babu Muhamed Jyoti R. Sharma Teke Apalata Sibusiso Nomatshila Lawrence Mabasa Mongi Benjeddou Charity Masilela Khanyisani Ziqubu Samukelisiwe Shabalala Rabia Johnson |
| author_facet | Sihle E. Mabhida Babu Muhamed Jyoti R. Sharma Teke Apalata Sibusiso Nomatshila Lawrence Mabasa Mongi Benjeddou Charity Masilela Khanyisani Ziqubu Samukelisiwe Shabalala Rabia Johnson |
| author_sort | Sihle E. Mabhida |
| collection | DOAJ |
| description | In this review, we have gathered and analyzed the available genetic evidence on the association between the methylenetetrahydrofolate reductase gene (<i>MTHFR</i>), rs1801133 and the risk of Hypertension (HTN) in African populations, which was further compared to the global data evidence. This review was reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol and Human Genome Epidemiology Network (HuGENet) guidelines. Literature was retrieved through major search databases, including PubMed, Scopus, Web of Science, and African Journal Online. We identified 64 potential studies, of which 4 studies were from the African continent and 60 studies were reported globally. Among the studies conducted in Africa, only two (<i>n</i> = 2) reported a significant association between the <i>MTHFR</i> (rs1801133) and the risk of developing HTN. Only one (<i>n</i> = 1) study population was purely composed of black Africans, while others were of other ethnicities. Among studies conducted in other continents (<i>n</i> = 60), forty-seven (<i>n</i> = 47) studies reported a positive association between <i>MTHFR</i> (rs1801133) and the risk of developing HTN, whereas the remaining studies (<i>n</i> = 14) did not show a significant association. Available literature suggests an apparent association between rs1801133 and HTN in global regions; however, such information is still scarce in Africa, especially in the black African population. |
| first_indexed | 2024-03-09T10:36:05Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T10:36:05Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-4cfcd345f79840328904206dbfa302922023-12-01T20:57:03ZengMDPI AGGenes2073-44252022-04-0113463110.3390/genes13040631Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of LiteratureSihle E. Mabhida0Babu Muhamed1Jyoti R. Sharma2Teke Apalata3Sibusiso Nomatshila4Lawrence Mabasa5Mongi Benjeddou6Charity Masilela7Khanyisani Ziqubu8Samukelisiwe Shabalala9Rabia Johnson10Biomedical Research and Innovation Platform, South African Medical Research Council (SAMRC), Tygerberg 7505, South AfricaDivision of Infections Disease, University of Tennessee Health Sciences Center (UTHSC), Memphis, TN 38163, USABiomedical Research and Innovation Platform, South African Medical Research Council (SAMRC), Tygerberg 7505, South AfricaDivision of Medical Microbiology, Department of Laboratory-Medicine and Pathology, Faculty of Health Sciences, Walter Sisulu University, Mthatha 5100, South AfricaDivision of Preventive Medicine and Health Behavior, Department of Public Health, Faculty of Health Sciences, Walter Sisulu University, Mthatha 5100, South AfricaBiomedical Research and Innovation Platform, South African Medical Research Council (SAMRC), Tygerberg 7505, South AfricaDepartment of Biotechnology, Faculty of Natural Science, University of the Western Cape, Private Bag X17, Bellville, Cape Town 7535, South AfricaDepartment of Biochemistry, North-West University, Mafikeng Campus, Mmabatho 2735, South AfricaDepartment of Biochemistry, North-West University, Mafikeng Campus, Mmabatho 2735, South AfricaBiomedical Research and Innovation Platform, South African Medical Research Council (SAMRC), Tygerberg 7505, South AfricaBiomedical Research and Innovation Platform, South African Medical Research Council (SAMRC), Tygerberg 7505, South AfricaIn this review, we have gathered and analyzed the available genetic evidence on the association between the methylenetetrahydrofolate reductase gene (<i>MTHFR</i>), rs1801133 and the risk of Hypertension (HTN) in African populations, which was further compared to the global data evidence. This review was reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol and Human Genome Epidemiology Network (HuGENet) guidelines. Literature was retrieved through major search databases, including PubMed, Scopus, Web of Science, and African Journal Online. We identified 64 potential studies, of which 4 studies were from the African continent and 60 studies were reported globally. Among the studies conducted in Africa, only two (<i>n</i> = 2) reported a significant association between the <i>MTHFR</i> (rs1801133) and the risk of developing HTN. Only one (<i>n</i> = 1) study population was purely composed of black Africans, while others were of other ethnicities. Among studies conducted in other continents (<i>n</i> = 60), forty-seven (<i>n</i> = 47) studies reported a positive association between <i>MTHFR</i> (rs1801133) and the risk of developing HTN, whereas the remaining studies (<i>n</i> = 14) did not show a significant association. Available literature suggests an apparent association between rs1801133 and HTN in global regions; however, such information is still scarce in Africa, especially in the black African population.https://www.mdpi.com/2073-4425/13/4/631Hypertensionmethylenetetrahydrofolate reductase gene<i>MTHFR</i>single-nucleotide polymorphismAfricagenetic variation |
| spellingShingle | Sihle E. Mabhida Babu Muhamed Jyoti R. Sharma Teke Apalata Sibusiso Nomatshila Lawrence Mabasa Mongi Benjeddou Charity Masilela Khanyisani Ziqubu Samukelisiwe Shabalala Rabia Johnson Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature Genes Hypertension methylenetetrahydrofolate reductase gene <i>MTHFR</i> single-nucleotide polymorphism Africa genetic variation |
| title | Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature |
| title_full | Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature |
| title_fullStr | Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature |
| title_full_unstemmed | Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature |
| title_short | Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature |
| title_sort | methylenetetrahydrofolate reductase polymorphism rs1801133 and the risk of hypertension among african populations a narrative synthesis of literature |
| topic | Hypertension methylenetetrahydrofolate reductase gene <i>MTHFR</i> single-nucleotide polymorphism Africa genetic variation |
| url | https://www.mdpi.com/2073-4425/13/4/631 |
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