A high-throughput multiparameter screen for accelerated development and optimization of soluble genetically encoded fluorescent biosensors
Fluorescent biosensors are important tools for studying cellular metabolism, but development and optimization are challenging. Koveal et al. present a high-throughput multiparameter screen for sensor performance, and used it to generate LiLac, a high-performance, quantitative lactate sensor.
| Main Authors: | , , , , , , , , |
|---|---|
| פורמט: | Article |
| שפה: | English |
| יצא לאור: |
Nature Portfolio
2022-05-01
|
| סדרה: | Nature Communications |
| גישה מקוונת: | https://doi.org/10.1038/s41467-022-30685-x |