CircRNA—Protein Interactions in Muscle Development and Diseases
Circular RNA (circRNA) is a kind of novel endogenous noncoding RNA formed through back-splicing of mRNA precursor. The biogenesis, degradation, nucleus–cytoplasm transport, location, and even translation of circRNA are controlled by RNA-binding proteins (RBPs). Therefore, circRNAs and the chaperoned...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/6/3262 |
| _version_ | 1797540288794722304 |
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| author | Shuailong Zheng Xujia Zhang Emmanuel Odame Xiaoli Xu Yuan Chen Jiangfeng Ye Helin Zhou Dinghui Dai Bismark Kyei Siyuan Zhan Jiaxue Cao Jiazhong Guo Tao Zhong Linjie Wang Li Li Hongping Zhang |
| author_facet | Shuailong Zheng Xujia Zhang Emmanuel Odame Xiaoli Xu Yuan Chen Jiangfeng Ye Helin Zhou Dinghui Dai Bismark Kyei Siyuan Zhan Jiaxue Cao Jiazhong Guo Tao Zhong Linjie Wang Li Li Hongping Zhang |
| author_sort | Shuailong Zheng |
| collection | DOAJ |
| description | Circular RNA (circRNA) is a kind of novel endogenous noncoding RNA formed through back-splicing of mRNA precursor. The biogenesis, degradation, nucleus–cytoplasm transport, location, and even translation of circRNA are controlled by RNA-binding proteins (RBPs). Therefore, circRNAs and the chaperoned RBPs play critical roles in biological functions that significantly contribute to normal animal development and disease. In this review, we systematically characterize the possible molecular mechanism of circRNA–protein interactions, summarize the latest research on circRNA–protein interactions in muscle development and myocardial disease, and discuss the future application of circRNA in treating muscle diseases. Finally, we provide several valid prediction methods and experimental verification approaches. Our review reveals the significance of circRNAs and their protein chaperones and provides a reference for further study in this field. |
| first_indexed | 2024-03-10T12:58:53Z |
| format | Article |
| id | doaj.art-4cfe0e4aab9a4e3fae9cbeee11668634 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:58:53Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4cfe0e4aab9a4e3fae9cbeee116686342023-11-21T11:40:41ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01226326210.3390/ijms22063262CircRNA—Protein Interactions in Muscle Development and DiseasesShuailong Zheng0Xujia Zhang1Emmanuel Odame2Xiaoli Xu3Yuan Chen4Jiangfeng Ye5Helin Zhou6Dinghui Dai7Bismark Kyei8Siyuan Zhan9Jiaxue Cao10Jiazhong Guo11Tao Zhong12Linjie Wang13Li Li14Hongping Zhang15Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaCircular RNA (circRNA) is a kind of novel endogenous noncoding RNA formed through back-splicing of mRNA precursor. The biogenesis, degradation, nucleus–cytoplasm transport, location, and even translation of circRNA are controlled by RNA-binding proteins (RBPs). Therefore, circRNAs and the chaperoned RBPs play critical roles in biological functions that significantly contribute to normal animal development and disease. In this review, we systematically characterize the possible molecular mechanism of circRNA–protein interactions, summarize the latest research on circRNA–protein interactions in muscle development and myocardial disease, and discuss the future application of circRNA in treating muscle diseases. Finally, we provide several valid prediction methods and experimental verification approaches. Our review reveals the significance of circRNAs and their protein chaperones and provides a reference for further study in this field.https://www.mdpi.com/1422-0067/22/6/3262musclecircRNARNA-binding proteinmolecular interactionsfunction |
| spellingShingle | Shuailong Zheng Xujia Zhang Emmanuel Odame Xiaoli Xu Yuan Chen Jiangfeng Ye Helin Zhou Dinghui Dai Bismark Kyei Siyuan Zhan Jiaxue Cao Jiazhong Guo Tao Zhong Linjie Wang Li Li Hongping Zhang CircRNA—Protein Interactions in Muscle Development and Diseases International Journal of Molecular Sciences muscle circRNA RNA-binding protein molecular interactions function |
| title | CircRNA—Protein Interactions in Muscle Development and Diseases |
| title_full | CircRNA—Protein Interactions in Muscle Development and Diseases |
| title_fullStr | CircRNA—Protein Interactions in Muscle Development and Diseases |
| title_full_unstemmed | CircRNA—Protein Interactions in Muscle Development and Diseases |
| title_short | CircRNA—Protein Interactions in Muscle Development and Diseases |
| title_sort | circrna protein interactions in muscle development and diseases |
| topic | muscle circRNA RNA-binding protein molecular interactions function |
| url | https://www.mdpi.com/1422-0067/22/6/3262 |
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