Anticancer Drug-Induced Acute Kidney Injury
Acute kidney injury (AKI) is a growing problem with untoward economic and medical consequences. Anticancer drug toxicity remains an important and increasing cause of AKI. Importantly, drug-induced AKI affects all nephron segments—vasculature, glomerulus, tubules, and interstitium. Recent studies hav...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-07-01
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| Series: | Kidney International Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468024917300384 |
| _version_ | 1811213343714705408 |
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| author | Hassan Izzedine Mark A. Perazella |
| author_facet | Hassan Izzedine Mark A. Perazella |
| author_sort | Hassan Izzedine |
| collection | DOAJ |
| description | Acute kidney injury (AKI) is a growing problem with untoward economic and medical consequences. Anticancer drug toxicity remains an important and increasing cause of AKI. Importantly, drug-induced AKI affects all nephron segments—vasculature, glomerulus, tubules, and interstitium. Recent studies have increased insight into the subcellular mechanisms of drug-induced AKI that include direct cellular toxicity and immune-mediated effects. Identification of patients with high-risk cancer before drug exposure may allow prevention or at least a reduction in the development and severity of nephrotoxicity. Recognition of drug-induced AKI and rapid discontinuation (or dose reduction) of the offending agents, when appropriate, are critical to maximizing kidney function recovery. Preventive measures require understanding patient and drug-related risk factors coupled with correcting risk factors, assessing baseline kidney function before initiation of therapy, adjusting the drug dosage and avoiding use of nephrotoxic drug combinations. |
| first_indexed | 2024-04-12T05:45:15Z |
| format | Article |
| id | doaj.art-4cfe12288fb34d9b9a0d52be39bc8202 |
| institution | Directory Open Access Journal |
| issn | 2468-0249 |
| language | English |
| last_indexed | 2024-04-12T05:45:15Z |
| publishDate | 2017-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney International Reports |
| spelling | doaj.art-4cfe12288fb34d9b9a0d52be39bc82022022-12-22T03:45:29ZengElsevierKidney International Reports2468-02492017-07-012450451410.1016/j.ekir.2017.02.008Anticancer Drug-Induced Acute Kidney InjuryHassan Izzedine0Mark A. Perazella1Department of Nephrology, Monceau Park International Clinic, Paris, FranceSection of Nephrology, Yale University School of Medicine, New Haven, Connecticut, USAAcute kidney injury (AKI) is a growing problem with untoward economic and medical consequences. Anticancer drug toxicity remains an important and increasing cause of AKI. Importantly, drug-induced AKI affects all nephron segments—vasculature, glomerulus, tubules, and interstitium. Recent studies have increased insight into the subcellular mechanisms of drug-induced AKI that include direct cellular toxicity and immune-mediated effects. Identification of patients with high-risk cancer before drug exposure may allow prevention or at least a reduction in the development and severity of nephrotoxicity. Recognition of drug-induced AKI and rapid discontinuation (or dose reduction) of the offending agents, when appropriate, are critical to maximizing kidney function recovery. Preventive measures require understanding patient and drug-related risk factors coupled with correcting risk factors, assessing baseline kidney function before initiation of therapy, adjusting the drug dosage and avoiding use of nephrotoxic drug combinations.http://www.sciencedirect.com/science/article/pii/S2468024917300384acute interstitial nephritisacute kidney injuryacute tubular necrosisdrug nephrotoxicityglomerulopathyonco-nephrologythrombotic microangiopathy |
| spellingShingle | Hassan Izzedine Mark A. Perazella Anticancer Drug-Induced Acute Kidney Injury Kidney International Reports acute interstitial nephritis acute kidney injury acute tubular necrosis drug nephrotoxicity glomerulopathy onco-nephrology thrombotic microangiopathy |
| title | Anticancer Drug-Induced Acute Kidney Injury |
| title_full | Anticancer Drug-Induced Acute Kidney Injury |
| title_fullStr | Anticancer Drug-Induced Acute Kidney Injury |
| title_full_unstemmed | Anticancer Drug-Induced Acute Kidney Injury |
| title_short | Anticancer Drug-Induced Acute Kidney Injury |
| title_sort | anticancer drug induced acute kidney injury |
| topic | acute interstitial nephritis acute kidney injury acute tubular necrosis drug nephrotoxicity glomerulopathy onco-nephrology thrombotic microangiopathy |
| url | http://www.sciencedirect.com/science/article/pii/S2468024917300384 |
| work_keys_str_mv | AT hassanizzedine anticancerdruginducedacutekidneyinjury AT markaperazella anticancerdruginducedacutekidneyinjury |