Bone marrow vasculature advanced in vitro models for cancer and cardiovascular research
Cardiometabolic diseases and cancer are among the most common diseases worldwide and are a serious concern to the healthcare system. These conditions, apparently distant, share common molecular and cellular determinants, that can represent targets for preventive and therapeutic approaches. The bone...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1261849/full |
| _version_ | 1797658501952045056 |
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| author | Marzia Campanile Leonardo Bettinelli Leonardo Bettinelli Camilla Cerutti Gaia Spinetti |
| author_facet | Marzia Campanile Leonardo Bettinelli Leonardo Bettinelli Camilla Cerutti Gaia Spinetti |
| author_sort | Marzia Campanile |
| collection | DOAJ |
| description | Cardiometabolic diseases and cancer are among the most common diseases worldwide and are a serious concern to the healthcare system. These conditions, apparently distant, share common molecular and cellular determinants, that can represent targets for preventive and therapeutic approaches. The bone marrow plays an important role in this context as it is the main source of cells involved in cardiovascular regeneration, and one of the main sites of liquid and solid tumor metastasis, both characterized by the cellular trafficking across the bone marrow vasculature. The bone marrow vasculature has been widely studied in animal models, however, it is clear the need for human-specific in vitro models, that resemble the bone vasculature lined by endothelial cells to study the molecular mechanisms governing cell trafficking. In this review, we summarized the current knowledge on in vitro models of bone marrow vasculature developed for cardiovascular and cancer research. |
| first_indexed | 2024-03-11T18:00:58Z |
| format | Article |
| id | doaj.art-4cff32f99bfb4211accd27f54191f33e |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-11T18:00:58Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-4cff32f99bfb4211accd27f54191f33e2023-10-17T08:53:20ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-10-011010.3389/fcvm.2023.12618491261849Bone marrow vasculature advanced in vitro models for cancer and cardiovascular researchMarzia Campanile0Leonardo Bettinelli1Leonardo Bettinelli2Camilla Cerutti3Gaia Spinetti4Laboratory of Cardiovascular Research, IRCCS MultiMedica, Milan, ItalyLaboratory of Cardiovascular Research, IRCCS MultiMedica, Milan, ItalyDepartment of Experimental Oncology, IRCCS-IEO, European Institute of Oncology, Milan, Italy.Department of Experimental Oncology, IRCCS-IEO, European Institute of Oncology, Milan, Italy.Laboratory of Cardiovascular Research, IRCCS MultiMedica, Milan, ItalyCardiometabolic diseases and cancer are among the most common diseases worldwide and are a serious concern to the healthcare system. These conditions, apparently distant, share common molecular and cellular determinants, that can represent targets for preventive and therapeutic approaches. The bone marrow plays an important role in this context as it is the main source of cells involved in cardiovascular regeneration, and one of the main sites of liquid and solid tumor metastasis, both characterized by the cellular trafficking across the bone marrow vasculature. The bone marrow vasculature has been widely studied in animal models, however, it is clear the need for human-specific in vitro models, that resemble the bone vasculature lined by endothelial cells to study the molecular mechanisms governing cell trafficking. In this review, we summarized the current knowledge on in vitro models of bone marrow vasculature developed for cardiovascular and cancer research.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1261849/fullbone marrow vasculaturein vitro modelsHSPC mobilizationcancerdiabetes |
| spellingShingle | Marzia Campanile Leonardo Bettinelli Leonardo Bettinelli Camilla Cerutti Gaia Spinetti Bone marrow vasculature advanced in vitro models for cancer and cardiovascular research Frontiers in Cardiovascular Medicine bone marrow vasculature in vitro models HSPC mobilization cancer diabetes |
| title | Bone marrow vasculature advanced in vitro models for cancer and cardiovascular research |
| title_full | Bone marrow vasculature advanced in vitro models for cancer and cardiovascular research |
| title_fullStr | Bone marrow vasculature advanced in vitro models for cancer and cardiovascular research |
| title_full_unstemmed | Bone marrow vasculature advanced in vitro models for cancer and cardiovascular research |
| title_short | Bone marrow vasculature advanced in vitro models for cancer and cardiovascular research |
| title_sort | bone marrow vasculature advanced in vitro models for cancer and cardiovascular research |
| topic | bone marrow vasculature in vitro models HSPC mobilization cancer diabetes |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1261849/full |
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