Human Recombinant DNase I (Pulmozyme<sup>®</sup>) Inhibits Lung Metastases in Murine Metastatic B16 Melanoma Model That Correlates with Restoration of the DNase Activity and the Decrease SINE/LINE and c-Myc Fragments in Blood Cell-Free DNA

Human Recombinant DNase I (Pulmozyme<sup>®</sup>) Inhibits Lung Metastases in Murine Metastatic B16 Melanoma Model That Correlates with Restoration of the DNase Activity and the Decrease SINE/LINE and c-Myc Fragments in Blood Cell-Free DNA

Tumor-associated cell-free DNAs (cfDNA) play an important role in the promotion of metastases. Previous studies proved the high antimetastatic potential of bovine pancreatic DNase I and identified short interspersed nuclear elements (SINEs) and long interspersed nuclear elements (LINEs)and fragments...

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Bibliographic Details
Main Authors: Ludmila Alekseeva, Aleksandra Sen’kova, Innokenty Savin, Marina Zenkova, Nadezhda Mironova
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
DNase I
Pulmozyme<sup>®</sup>
drug repurposing
circulating cell-free DNA
neutrophil extracellular traps
SINE elements
Online Access:https://www.mdpi.com/1422-0067/22/21/12074

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