Oxidative Stress-Induced Cellular Senescence: Is Labile Iron the Connecting Link?
Cellular senescence, a cell state characterized by a generally irreversible cell cycle arrest, is implicated in various physiological processes and a wide range of age-related pathologies. Oxidative stress, a condition caused by an imbalance between the production and the elimination of reactive oxy...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/6/1250 |
| _version_ | 1827738830784954368 |
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| author | Lambros Nousis Panagiotis Kanavaros Alexandra Barbouti |
| author_facet | Lambros Nousis Panagiotis Kanavaros Alexandra Barbouti |
| author_sort | Lambros Nousis |
| collection | DOAJ |
| description | Cellular senescence, a cell state characterized by a generally irreversible cell cycle arrest, is implicated in various physiological processes and a wide range of age-related pathologies. Oxidative stress, a condition caused by an imbalance between the production and the elimination of reactive oxygen species (ROS) in cells and tissues, is a common driver of cellular senescence. ROS encompass free radicals and other molecules formed as byproducts of oxygen metabolism, which exhibit varying chemical reactivity. A prerequisite for the generation of strong oxidizing ROS that can damage macromolecules and impair cellular function is the availability of labile (redox-active) iron, which catalyzes the formation of highly reactive free radicals. Targeting labile iron has been proven an effective strategy to counteract the adverse effects of ROS, but evidence concerning cellular senescence is sparse. In the present review article, we discuss aspects of oxidative stress-induced cellular senescence, with special attention to the potential implication of labile iron. |
| first_indexed | 2024-03-11T02:49:35Z |
| format | Article |
| id | doaj.art-4d046eebd0f6484e8df9ac32dda30dec |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T02:49:35Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-4d046eebd0f6484e8df9ac32dda30dec2023-11-18T09:03:34ZengMDPI AGAntioxidants2076-39212023-06-01126125010.3390/antiox12061250Oxidative Stress-Induced Cellular Senescence: Is Labile Iron the Connecting Link?Lambros Nousis0Panagiotis Kanavaros1Alexandra Barbouti2Department of Hygiene and Epidemiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, GreeceDepartment of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, GreeceDepartment of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, GreeceCellular senescence, a cell state characterized by a generally irreversible cell cycle arrest, is implicated in various physiological processes and a wide range of age-related pathologies. Oxidative stress, a condition caused by an imbalance between the production and the elimination of reactive oxygen species (ROS) in cells and tissues, is a common driver of cellular senescence. ROS encompass free radicals and other molecules formed as byproducts of oxygen metabolism, which exhibit varying chemical reactivity. A prerequisite for the generation of strong oxidizing ROS that can damage macromolecules and impair cellular function is the availability of labile (redox-active) iron, which catalyzes the formation of highly reactive free radicals. Targeting labile iron has been proven an effective strategy to counteract the adverse effects of ROS, but evidence concerning cellular senescence is sparse. In the present review article, we discuss aspects of oxidative stress-induced cellular senescence, with special attention to the potential implication of labile iron.https://www.mdpi.com/2076-3921/12/6/1250oxidative stressreactive oxygen specieslabile ironcellular senescencetelomeresDNA-damage |
| spellingShingle | Lambros Nousis Panagiotis Kanavaros Alexandra Barbouti Oxidative Stress-Induced Cellular Senescence: Is Labile Iron the Connecting Link? Antioxidants oxidative stress reactive oxygen species labile iron cellular senescence telomeres DNA-damage |
| title | Oxidative Stress-Induced Cellular Senescence: Is Labile Iron the Connecting Link? |
| title_full | Oxidative Stress-Induced Cellular Senescence: Is Labile Iron the Connecting Link? |
| title_fullStr | Oxidative Stress-Induced Cellular Senescence: Is Labile Iron the Connecting Link? |
| title_full_unstemmed | Oxidative Stress-Induced Cellular Senescence: Is Labile Iron the Connecting Link? |
| title_short | Oxidative Stress-Induced Cellular Senescence: Is Labile Iron the Connecting Link? |
| title_sort | oxidative stress induced cellular senescence is labile iron the connecting link |
| topic | oxidative stress reactive oxygen species labile iron cellular senescence telomeres DNA-damage |
| url | https://www.mdpi.com/2076-3921/12/6/1250 |
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