Early on-treatment plasma interleukin-18 as a promising indicator for long-term virological response in patients with HIV-1 infection
Background and aimsIt is necessary to identify simple biomarkers that can efficiently predict the efficacy of long-term antiretroviral therapy (ART) against human immunodeficiency virus (HIV), especially in underdeveloped countries. We characterized the dynamic changes in plasma interleukin-18 (IL-1...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1170208/full |
| _version_ | 1797805750342385664 |
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| author | Weiyin Lin Liya Li Pengle Guo Yaozu He Haolan He Hong Li Huolin Zhong Cong Liu Peishan Du Weiping Cai Xiaoping Tang Linghua Li |
| author_facet | Weiyin Lin Liya Li Pengle Guo Yaozu He Haolan He Hong Li Huolin Zhong Cong Liu Peishan Du Weiping Cai Xiaoping Tang Linghua Li |
| author_sort | Weiyin Lin |
| collection | DOAJ |
| description | Background and aimsIt is necessary to identify simple biomarkers that can efficiently predict the efficacy of long-term antiretroviral therapy (ART) against human immunodeficiency virus (HIV), especially in underdeveloped countries. We characterized the dynamic changes in plasma interleukin-18 (IL-18) and assessed its performance as a predictor of long-term virological response.MethodsThis was a retrospective cohort study of HIV-1-infected patients enrolled in a randomized controlled trial with a follow-up of 144 weeks of ART. Enzyme-linked immunosorbent assay was performed to evaluate plasma IL-18. Long-term virological response was defined as HIV-1 RNA <20 copies/mL at week 144.ResultsAmong the 173 enrolled patients, the long-term virological response rate was 93.1%. Patients with a long-term virological response had significantly lower levels of week 24 IL-18 than non-responders. We defined 64 pg./mL, with a maximum sum of sensitivity and specificity, as the optimal cutoff value of week 24 IL-18 level to predict long-term virological response. After adjusting for age, gender, baseline CD4+ T-cell count, baseline CD4/CD8 ratio, baseline HIV-1 RNA level, HIV-1 genotype and treatment strategy, we found that lower week 24 IL-18 level (≤64 vs. >64 pg./mL, a OR 19.10, 95% CI: 2.36–154.80) was the only independent predictor of long-term virological response.ConclusionEarly on-treatment plasma IL-18 could act as a promising indicator for long-term virological response in patients with HIV-1 infection. Chronic immune activation and inflammation may represent a potential mechanism; further validation is necessary. |
| first_indexed | 2024-03-13T05:56:46Z |
| format | Article |
| id | doaj.art-4d0734ffed42496abb0ac42624a634f4 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-13T05:56:46Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-4d0734ffed42496abb0ac42624a634f42023-06-13T04:29:46ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-06-011010.3389/fmed.2023.11702081170208Early on-treatment plasma interleukin-18 as a promising indicator for long-term virological response in patients with HIV-1 infectionWeiyin LinLiya LiPengle GuoYaozu HeHaolan HeHong LiHuolin ZhongCong LiuPeishan DuWeiping CaiXiaoping TangLinghua LiBackground and aimsIt is necessary to identify simple biomarkers that can efficiently predict the efficacy of long-term antiretroviral therapy (ART) against human immunodeficiency virus (HIV), especially in underdeveloped countries. We characterized the dynamic changes in plasma interleukin-18 (IL-18) and assessed its performance as a predictor of long-term virological response.MethodsThis was a retrospective cohort study of HIV-1-infected patients enrolled in a randomized controlled trial with a follow-up of 144 weeks of ART. Enzyme-linked immunosorbent assay was performed to evaluate plasma IL-18. Long-term virological response was defined as HIV-1 RNA <20 copies/mL at week 144.ResultsAmong the 173 enrolled patients, the long-term virological response rate was 93.1%. Patients with a long-term virological response had significantly lower levels of week 24 IL-18 than non-responders. We defined 64 pg./mL, with a maximum sum of sensitivity and specificity, as the optimal cutoff value of week 24 IL-18 level to predict long-term virological response. After adjusting for age, gender, baseline CD4+ T-cell count, baseline CD4/CD8 ratio, baseline HIV-1 RNA level, HIV-1 genotype and treatment strategy, we found that lower week 24 IL-18 level (≤64 vs. >64 pg./mL, a OR 19.10, 95% CI: 2.36–154.80) was the only independent predictor of long-term virological response.ConclusionEarly on-treatment plasma IL-18 could act as a promising indicator for long-term virological response in patients with HIV-1 infection. Chronic immune activation and inflammation may represent a potential mechanism; further validation is necessary.https://www.frontiersin.org/articles/10.3389/fmed.2023.1170208/fullHIV-1IL-18indicatorlong-termvirological response |
| spellingShingle | Weiyin Lin Liya Li Pengle Guo Yaozu He Haolan He Hong Li Huolin Zhong Cong Liu Peishan Du Weiping Cai Xiaoping Tang Linghua Li Early on-treatment plasma interleukin-18 as a promising indicator for long-term virological response in patients with HIV-1 infection Frontiers in Medicine HIV-1 IL-18 indicator long-term virological response |
| title | Early on-treatment plasma interleukin-18 as a promising indicator for long-term virological response in patients with HIV-1 infection |
| title_full | Early on-treatment plasma interleukin-18 as a promising indicator for long-term virological response in patients with HIV-1 infection |
| title_fullStr | Early on-treatment plasma interleukin-18 as a promising indicator for long-term virological response in patients with HIV-1 infection |
| title_full_unstemmed | Early on-treatment plasma interleukin-18 as a promising indicator for long-term virological response in patients with HIV-1 infection |
| title_short | Early on-treatment plasma interleukin-18 as a promising indicator for long-term virological response in patients with HIV-1 infection |
| title_sort | early on treatment plasma interleukin 18 as a promising indicator for long term virological response in patients with hiv 1 infection |
| topic | HIV-1 IL-18 indicator long-term virological response |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1170208/full |
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