Structural brain alterations and their association with cognitive function and symptoms in Attention-deficit/Hyperactivity Disorder families
Gray matter disruptions have been found consistently in Attention-deficit/Hyperactivity Disorder (ADHD). The organization of these alterations into brain structural networks remains largely unexplored. We investigated 508 participants (281 males) with ADHD (N = 210), their unaffected siblings (N = 1...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-01-01
|
| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158220301108 |
| _version_ | 1828851445744533504 |
|---|---|
| author | Wenhao Jiang Kuaikuai Duan Kelly Rootes-Murdy Pieter J. Hoekstra Catharina A. Hartman Jaap Oosterlaan Dirk Heslenfeld Barbara Franke Jan Buitelaar Alejandro Arias-Vasquez Jingyu Liu Jessica A. Turner |
| author_facet | Wenhao Jiang Kuaikuai Duan Kelly Rootes-Murdy Pieter J. Hoekstra Catharina A. Hartman Jaap Oosterlaan Dirk Heslenfeld Barbara Franke Jan Buitelaar Alejandro Arias-Vasquez Jingyu Liu Jessica A. Turner |
| author_sort | Wenhao Jiang |
| collection | DOAJ |
| description | Gray matter disruptions have been found consistently in Attention-deficit/Hyperactivity Disorder (ADHD). The organization of these alterations into brain structural networks remains largely unexplored. We investigated 508 participants (281 males) with ADHD (N = 210), their unaffected siblings (N = 108), individuals with subthreshold ADHD (N = 49), and unrelated healthy controls (N = 141) with an age range from 7 to 18 years old from 336 families in the Dutch NeuroIMAGE project. Source based morphometry was used to examine structural brain network alterations and their association with symptoms and cognitive performance. Two networks showed significant reductions in individuals with ADHD compared to unrelated healthy controls after False Discovery Rate correction. Component A, mainly located in bilateral Crus I, showed a ADHD/typically developing difference with subthreshold cases being intermediate between ADHD and typically developing controls. The unaffected siblings were similar to controls. After correcting for IQ and medication status, component A showed a negative correlation with inattention symptoms across the entire sample. Component B included a maximum cluster in the bilateral insula, where unaffected siblings, similar to individuals with ADHD, showed significantly reduced loadings compared to controls; but no relationship with individual symptoms or cognitive measures was found for component B. This multivariate approach suggests that areas reflecting genetic liability within ADHD are partly separate from those areas modulating symptom severity. |
| first_indexed | 2024-12-12T23:32:51Z |
| format | Article |
| id | doaj.art-4d073564633b49788fc3d4f14c98d689 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-12T23:32:51Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-4d073564633b49788fc3d4f14c98d6892022-12-22T00:07:40ZengElsevierNeuroImage: Clinical2213-15822020-01-0127102273Structural brain alterations and their association with cognitive function and symptoms in Attention-deficit/Hyperactivity Disorder familiesWenhao Jiang0Kuaikuai Duan1Kelly Rootes-Murdy2Pieter J. Hoekstra3Catharina A. Hartman4Jaap Oosterlaan5Dirk Heslenfeld6Barbara Franke7Jan Buitelaar8Alejandro Arias-Vasquez9Jingyu Liu10Jessica A. Turner11Department of Psychology, Georgia State University, USASchool of Electrical and Computer Engineering, Georgia Institute of Technology, USADepartment of Psychology, Georgia State University, USAUniversity of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The NetherlandsUniversity of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The NetherlandsDepartment of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The NetherlandsDepartment of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The NetherlandsDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The NetherlandsDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The NetherlandsDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The NetherlandsDepartment of Computer Science, TReNDS Center, Georgia State University, Atlanta, USADepartment of Psychology, Georgia State University, USA; Neuroscience Institute, Georgia State University, USA; Corresponding author at: Psychology and Neuroscience, Georgia State University, Atlanta, GA, USA.Gray matter disruptions have been found consistently in Attention-deficit/Hyperactivity Disorder (ADHD). The organization of these alterations into brain structural networks remains largely unexplored. We investigated 508 participants (281 males) with ADHD (N = 210), their unaffected siblings (N = 108), individuals with subthreshold ADHD (N = 49), and unrelated healthy controls (N = 141) with an age range from 7 to 18 years old from 336 families in the Dutch NeuroIMAGE project. Source based morphometry was used to examine structural brain network alterations and their association with symptoms and cognitive performance. Two networks showed significant reductions in individuals with ADHD compared to unrelated healthy controls after False Discovery Rate correction. Component A, mainly located in bilateral Crus I, showed a ADHD/typically developing difference with subthreshold cases being intermediate between ADHD and typically developing controls. The unaffected siblings were similar to controls. After correcting for IQ and medication status, component A showed a negative correlation with inattention symptoms across the entire sample. Component B included a maximum cluster in the bilateral insula, where unaffected siblings, similar to individuals with ADHD, showed significantly reduced loadings compared to controls; but no relationship with individual symptoms or cognitive measures was found for component B. This multivariate approach suggests that areas reflecting genetic liability within ADHD are partly separate from those areas modulating symptom severity.http://www.sciencedirect.com/science/article/pii/S2213158220301108ADHDIndependent component analysisCerebellumInsulaInattention |
| spellingShingle | Wenhao Jiang Kuaikuai Duan Kelly Rootes-Murdy Pieter J. Hoekstra Catharina A. Hartman Jaap Oosterlaan Dirk Heslenfeld Barbara Franke Jan Buitelaar Alejandro Arias-Vasquez Jingyu Liu Jessica A. Turner Structural brain alterations and their association with cognitive function and symptoms in Attention-deficit/Hyperactivity Disorder families NeuroImage: Clinical ADHD Independent component analysis Cerebellum Insula Inattention |
| title | Structural brain alterations and their association with cognitive function and symptoms in Attention-deficit/Hyperactivity Disorder families |
| title_full | Structural brain alterations and their association with cognitive function and symptoms in Attention-deficit/Hyperactivity Disorder families |
| title_fullStr | Structural brain alterations and their association with cognitive function and symptoms in Attention-deficit/Hyperactivity Disorder families |
| title_full_unstemmed | Structural brain alterations and their association with cognitive function and symptoms in Attention-deficit/Hyperactivity Disorder families |
| title_short | Structural brain alterations and their association with cognitive function and symptoms in Attention-deficit/Hyperactivity Disorder families |
| title_sort | structural brain alterations and their association with cognitive function and symptoms in attention deficit hyperactivity disorder families |
| topic | ADHD Independent component analysis Cerebellum Insula Inattention |
| url | http://www.sciencedirect.com/science/article/pii/S2213158220301108 |
| work_keys_str_mv | AT wenhaojiang structuralbrainalterationsandtheirassociationwithcognitivefunctionandsymptomsinattentiondeficithyperactivitydisorderfamilies AT kuaikuaiduan structuralbrainalterationsandtheirassociationwithcognitivefunctionandsymptomsinattentiondeficithyperactivitydisorderfamilies AT kellyrootesmurdy structuralbrainalterationsandtheirassociationwithcognitivefunctionandsymptomsinattentiondeficithyperactivitydisorderfamilies AT pieterjhoekstra structuralbrainalterationsandtheirassociationwithcognitivefunctionandsymptomsinattentiondeficithyperactivitydisorderfamilies AT catharinaahartman structuralbrainalterationsandtheirassociationwithcognitivefunctionandsymptomsinattentiondeficithyperactivitydisorderfamilies AT jaapoosterlaan structuralbrainalterationsandtheirassociationwithcognitivefunctionandsymptomsinattentiondeficithyperactivitydisorderfamilies AT dirkheslenfeld structuralbrainalterationsandtheirassociationwithcognitivefunctionandsymptomsinattentiondeficithyperactivitydisorderfamilies AT barbarafranke structuralbrainalterationsandtheirassociationwithcognitivefunctionandsymptomsinattentiondeficithyperactivitydisorderfamilies AT janbuitelaar structuralbrainalterationsandtheirassociationwithcognitivefunctionandsymptomsinattentiondeficithyperactivitydisorderfamilies AT alejandroariasvasquez structuralbrainalterationsandtheirassociationwithcognitivefunctionandsymptomsinattentiondeficithyperactivitydisorderfamilies AT jingyuliu structuralbrainalterationsandtheirassociationwithcognitivefunctionandsymptomsinattentiondeficithyperactivitydisorderfamilies AT jessicaaturner structuralbrainalterationsandtheirassociationwithcognitivefunctionandsymptomsinattentiondeficithyperactivitydisorderfamilies |