Proton therapy for isolated local regional recurrence of breast cancer after mastectomy alone
Purpose/ObjectivesTo assess adverse events (AEs) and disease-specific outcomes after proton therapy for isolated local-regional recurrence (LRR) of breast cancer after mastectomy without prior radiotherapy (RT).Materials/MethodsPatients were identified from a multi-institutional prospective registry...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.925078/full |
| _version_ | 1828096669190717440 |
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| author | Brady S. Laughlin Ronik S. Bhangoo Joshua R. Niska Cameron S. Thorpe Marlene E. Girardo Justin D. Anderson Heidi E. Kosiorek Lisa A. McGee William F. Hartsell John H. Chang Carl J. Rossi Henry K. Tsai Isabelle J. Choi Carlos E. Vargas |
| author_facet | Brady S. Laughlin Ronik S. Bhangoo Joshua R. Niska Cameron S. Thorpe Marlene E. Girardo Justin D. Anderson Heidi E. Kosiorek Lisa A. McGee William F. Hartsell John H. Chang Carl J. Rossi Henry K. Tsai Isabelle J. Choi Carlos E. Vargas |
| author_sort | Brady S. Laughlin |
| collection | DOAJ |
| description | Purpose/ObjectivesTo assess adverse events (AEs) and disease-specific outcomes after proton therapy for isolated local-regional recurrence (LRR) of breast cancer after mastectomy without prior radiotherapy (RT).Materials/MethodsPatients were identified from a multi-institutional prospective registry and included if diagnosed with invasive breast cancer, initially underwent mastectomy without adjuvant RT, experienced an LRR, and subsequently underwent salvage treatment, including proton therapy. Follow-up and cancer outcomes were measured from the date of RT completion.ResultsNineteen patients were included. Seventeen patients were treated with proton therapy to the chest wall and comprehensive regional lymphatics (17/19, 90%). Maximum grade AE was grade 2 in 13 (69%) patients and grade 3 in 4 (21%) patients. All patients with grade 3 AE received > 60 GyE (p=0.04, Spearman correlation coefficient=0.5). At the last follow-up, 90% of patients were alive with no LRR or distant recurrence.ConclusionsFor breast cancer patients with isolated LRR after initial mastectomy without adjuvant RT, proton therapy is well-tolerated in the salvage setting with excellent loco-regional control. All grade 3 AEs occurred in patients receiving > 60 GyE. |
| first_indexed | 2024-04-11T07:35:08Z |
| format | Article |
| id | doaj.art-4d082877effa44838ed86aa178a4acf2 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T07:35:08Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4d082877effa44838ed86aa178a4acf22022-12-22T04:36:46ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-11-011210.3389/fonc.2022.925078925078Proton therapy for isolated local regional recurrence of breast cancer after mastectomy aloneBrady S. Laughlin0Ronik S. Bhangoo1Joshua R. Niska2Cameron S. Thorpe3Marlene E. Girardo4Justin D. Anderson5Heidi E. Kosiorek6Lisa A. McGee7William F. Hartsell8John H. Chang9Carl J. Rossi10Henry K. Tsai11Isabelle J. Choi12Carlos E. Vargas13Department of Radiation Oncology Mayo Clinic, Phoenix, AZ, United StatesDepartment of Radiation Oncology Mayo Clinic, Phoenix, AZ, United StatesDepartment of Radiation Oncology Mayo Clinic, Phoenix, AZ, United StatesDepartment of Radiation Oncology Mayo Clinic, Phoenix, AZ, United StatesHealth Sciences Research, Division of Biostatistics, Mayo Clinic, Scottsdale, AZ, United StatesDepartment of Radiation Oncology Mayo Clinic, Phoenix, AZ, United StatesHealth Sciences Research, Division of Biostatistics, Mayo Clinic, Scottsdale, AZ, United StatesDepartment of Radiation Oncology Mayo Clinic, Phoenix, AZ, United StatesNorthwestern Medicine Chicago Proton Center, Warrenville, IL, United StatesProCure Proton Therapy Center, Oklahoma City, OK, United StatesScripps Proton Therapy Center, San Diego, CA, United StatesProCure Proton Therapy Center, Somerset, NJ, United StatesNew York Proton Center, New York, NY, United StatesDepartment of Radiation Oncology Mayo Clinic, Phoenix, AZ, United StatesPurpose/ObjectivesTo assess adverse events (AEs) and disease-specific outcomes after proton therapy for isolated local-regional recurrence (LRR) of breast cancer after mastectomy without prior radiotherapy (RT).Materials/MethodsPatients were identified from a multi-institutional prospective registry and included if diagnosed with invasive breast cancer, initially underwent mastectomy without adjuvant RT, experienced an LRR, and subsequently underwent salvage treatment, including proton therapy. Follow-up and cancer outcomes were measured from the date of RT completion.ResultsNineteen patients were included. Seventeen patients were treated with proton therapy to the chest wall and comprehensive regional lymphatics (17/19, 90%). Maximum grade AE was grade 2 in 13 (69%) patients and grade 3 in 4 (21%) patients. All patients with grade 3 AE received > 60 GyE (p=0.04, Spearman correlation coefficient=0.5). At the last follow-up, 90% of patients were alive with no LRR or distant recurrence.ConclusionsFor breast cancer patients with isolated LRR after initial mastectomy without adjuvant RT, proton therapy is well-tolerated in the salvage setting with excellent loco-regional control. All grade 3 AEs occurred in patients receiving > 60 GyE.https://www.frontiersin.org/articles/10.3389/fonc.2022.925078/fullbreast cancerpost-mastectomy radiotherapyprotonslocal recurrencePMRT |
| spellingShingle | Brady S. Laughlin Ronik S. Bhangoo Joshua R. Niska Cameron S. Thorpe Marlene E. Girardo Justin D. Anderson Heidi E. Kosiorek Lisa A. McGee William F. Hartsell John H. Chang Carl J. Rossi Henry K. Tsai Isabelle J. Choi Carlos E. Vargas Proton therapy for isolated local regional recurrence of breast cancer after mastectomy alone Frontiers in Oncology breast cancer post-mastectomy radiotherapy protons local recurrence PMRT |
| title | Proton therapy for isolated local regional recurrence of breast cancer after mastectomy alone |
| title_full | Proton therapy for isolated local regional recurrence of breast cancer after mastectomy alone |
| title_fullStr | Proton therapy for isolated local regional recurrence of breast cancer after mastectomy alone |
| title_full_unstemmed | Proton therapy for isolated local regional recurrence of breast cancer after mastectomy alone |
| title_short | Proton therapy for isolated local regional recurrence of breast cancer after mastectomy alone |
| title_sort | proton therapy for isolated local regional recurrence of breast cancer after mastectomy alone |
| topic | breast cancer post-mastectomy radiotherapy protons local recurrence PMRT |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.925078/full |
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