The effect of resistance training with liposomal vitamin C on UCP1 and FIS1 expression in hepatocytes of elderly rats
Background: Aging can increase the risks of various liver diseases and act as an unfavorable prognostic factor and increase mortality. Therefore, this study aimed to investigate the effect of 8-week resistance training with liposomal vitamin C on the expression of UCP1 and FIS1 in hepatocytes of...
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| Format: | Article |
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Kashan University of Medical Sciences and Health Services
2022-04-01
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| Series: | Fiyz̤ |
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| Online Access: | http://feyz.kaums.ac.ir/article-1-4505-en.html |
| _version_ | 1818027354760413184 |
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| author | Mostafa Khodabandeh Maghsoud Peeri Mohammad Ali Azarbayjani Hassan Matinhomaee |
| author_facet | Mostafa Khodabandeh Maghsoud Peeri Mohammad Ali Azarbayjani Hassan Matinhomaee |
| author_sort | Mostafa Khodabandeh |
| collection | DOAJ |
| description | Background: Aging can increase the risks of various liver diseases and act as an
unfavorable prognostic factor and increase mortality. Therefore, this study aimed to
investigate the effect of 8-week resistance training with liposomal vitamin C on the
expression of UCP1 and FIS1 in hepatocytes of elderly rats.
Material and Methods: The present study was an experimental study with a control group.
Twenty-five male rats (Wistar) aged 24 weeks (280-320 g) were randomly divided into 5
groups; young control group, elderly + resistance training group, elderly + liposomal vitamin
C group, elderly + resistance training + liposomal vitamin C group and old age control
group. In the groups receiving liposomal vitamin C, liposomal vitamin C was administered
daily based on kilograms of body weight.
Results: UCP1 expression was significantly reduced in the elderly group compared to the
young group (P=0.001). However, the expression of UCP1 in the elderly group + resistance
training along with vitamin C consumption increased significantly compared to the elderly
group (P=0.001). Also, FIS1 expression was significantly increased in the elderly group
compared to the young group (P=0.001). However, the expression of FIS1 in the elderly
group + resistance training with vitamin C consumption was significantly reduced compared
to the young group (P=0.001).
Results: Aging increases FIS1 expression and decreases UCP1 expression in rat liver tissue.
However, resistance training with vitamin C decreases FIS1 expression and increases UCP1
expression in elderly rats |
| first_indexed | 2024-12-10T04:46:34Z |
| format | Article |
| id | doaj.art-4d0aa086d2324ff7969bd460cee6c38a |
| institution | Directory Open Access Journal |
| issn | 1029-7855 2008-9821 |
| language | fas |
| last_indexed | 2024-12-10T04:46:34Z |
| publishDate | 2022-04-01 |
| publisher | Kashan University of Medical Sciences and Health Services |
| record_format | Article |
| series | Fiyz̤ |
| spelling | doaj.art-4d0aa086d2324ff7969bd460cee6c38a2022-12-22T02:01:43ZfasKashan University of Medical Sciences and Health ServicesFiyz̤1029-78552008-98212022-04-012612229The effect of resistance training with liposomal vitamin C on UCP1 and FIS1 expression in hepatocytes of elderly ratsMostafa Khodabandeh0 Maghsoud Peeri1 Mohammad Ali Azarbayjani2 Hassan Matinhomaee 3Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, Central Tehran Branch, Islamic Azad University, Tehran, I.R. Iran.Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, Central Tehran Branch, Islamic Azad University, Tehran, I.R. Iran.Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, Central Tehran Branch, Islamic Azad University, Tehran, I.R. Iran.Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, Central Tehran Branch, Islamic Azad University, Tehran, I.R. Iran.Background: Aging can increase the risks of various liver diseases and act as an unfavorable prognostic factor and increase mortality. Therefore, this study aimed to investigate the effect of 8-week resistance training with liposomal vitamin C on the expression of UCP1 and FIS1 in hepatocytes of elderly rats. Material and Methods: The present study was an experimental study with a control group. Twenty-five male rats (Wistar) aged 24 weeks (280-320 g) were randomly divided into 5 groups; young control group, elderly + resistance training group, elderly + liposomal vitamin C group, elderly + resistance training + liposomal vitamin C group and old age control group. In the groups receiving liposomal vitamin C, liposomal vitamin C was administered daily based on kilograms of body weight. Results: UCP1 expression was significantly reduced in the elderly group compared to the young group (P=0.001). However, the expression of UCP1 in the elderly group + resistance training along with vitamin C consumption increased significantly compared to the elderly group (P=0.001). Also, FIS1 expression was significantly increased in the elderly group compared to the young group (P=0.001). However, the expression of FIS1 in the elderly group + resistance training with vitamin C consumption was significantly reduced compared to the young group (P=0.001). Results: Aging increases FIS1 expression and decreases UCP1 expression in rat liver tissue. However, resistance training with vitamin C decreases FIS1 expression and increases UCP1 expression in elderly ratshttp://feyz.kaums.ac.ir/article-1-4505-en.htmlresistance trainingvitamin cucpfis1 |
| spellingShingle | Mostafa Khodabandeh Maghsoud Peeri Mohammad Ali Azarbayjani Hassan Matinhomaee The effect of resistance training with liposomal vitamin C on UCP1 and FIS1 expression in hepatocytes of elderly rats Fiyz̤ resistance training vitamin c ucp fis1 |
| title | The effect of resistance training with liposomal vitamin C on UCP1 and FIS1 expression in hepatocytes of elderly rats |
| title_full | The effect of resistance training with liposomal vitamin C on UCP1 and FIS1 expression in hepatocytes of elderly rats |
| title_fullStr | The effect of resistance training with liposomal vitamin C on UCP1 and FIS1 expression in hepatocytes of elderly rats |
| title_full_unstemmed | The effect of resistance training with liposomal vitamin C on UCP1 and FIS1 expression in hepatocytes of elderly rats |
| title_short | The effect of resistance training with liposomal vitamin C on UCP1 and FIS1 expression in hepatocytes of elderly rats |
| title_sort | effect of resistance training with liposomal vitamin c on ucp1 and fis1 expression in hepatocytes of elderly rats |
| topic | resistance training vitamin c ucp fis1 |
| url | http://feyz.kaums.ac.ir/article-1-4505-en.html |
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