Protein and Antigen Diversity in the Vesicular Fluid of Taenia Solium Cysticerci Dissected from Naturally Infected Pigs
<p>Cysticercosis caused by <i>Taenia solium</i> is a health threat for humans and pigs living in developing countries, for which there is neither a flawless immunodiagnostic test nor a totally effective vaccine. Suspecting of individual diversity of hosts and parasites as possible...
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| Format: | Article |
| Language: | English |
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Ivyspring International Publisher
2011-01-01
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| Series: | International Journal of Biological Sciences |
| Online Access: | http://www.biolsci.org/v07p1287.htm |
| _version_ | 1818153279270420480 |
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| author | Marcela Esquivel-Velázquez, Carlos Larralde, Julio Morales, Pedro Ostoa-Saloma |
| author_facet | Marcela Esquivel-Velázquez, Carlos Larralde, Julio Morales, Pedro Ostoa-Saloma |
| author_sort | Marcela Esquivel-Velázquez, Carlos Larralde, Julio Morales, Pedro Ostoa-Saloma |
| collection | DOAJ |
| description | <p>Cysticercosis caused by <i>Taenia solium</i> is a health threat for humans and pigs living in developing countries, for which there is neither a flawless immunodiagnostic test nor a totally effective vaccine. Suspecting of individual diversity of hosts and parasites as possible sources of the variations of the parasite loads among cysticercotic animals and of the limited success of such immunological applications as well as, we explored and measured both in nine cases of naturally acquired porcine cysticercosis. For this purpose, 2-Dimensional IgG immunoblots were performed by reacting the sera of each cysticercotic pig with the antigens contained in the vesicular fluid (VF) of their own cysticerci. We found an unexpectedly large diversity among the proteins and antigens contained in each of the nine VFs. Also diverse were the serum IgG antibody responses of the nine pigs, as none of their 2D- immunoblot images exhibited the same number of spots and resembled each other in only 6.3% to 65.3% of their features. So large an individual immunological diversity of the cysticercal antigens and of the infected pigs´ IgG antibody response should be taken into account in the design of immunological tools for diagnosis and prevention of cysticercosis and should also be considered as a possibly significant source of diversity in <i>Taenia solium´s</i> infectiveness and pathogenicity.</p> |
| first_indexed | 2024-12-11T14:08:05Z |
| format | Article |
| id | doaj.art-4d0d18fff4f4456cb50d03c546a60b71 |
| institution | Directory Open Access Journal |
| issn | 1449-2288 |
| language | English |
| last_indexed | 2024-12-11T14:08:05Z |
| publishDate | 2011-01-01 |
| publisher | Ivyspring International Publisher |
| record_format | Article |
| series | International Journal of Biological Sciences |
| spelling | doaj.art-4d0d18fff4f4456cb50d03c546a60b712022-12-22T01:03:34ZengIvyspring International PublisherInternational Journal of Biological Sciences1449-22882011-01-017912871297Protein and Antigen Diversity in the Vesicular Fluid of Taenia Solium Cysticerci Dissected from Naturally Infected PigsMarcela Esquivel-Velázquez, Carlos Larralde, Julio Morales, Pedro Ostoa-Saloma<p>Cysticercosis caused by <i>Taenia solium</i> is a health threat for humans and pigs living in developing countries, for which there is neither a flawless immunodiagnostic test nor a totally effective vaccine. Suspecting of individual diversity of hosts and parasites as possible sources of the variations of the parasite loads among cysticercotic animals and of the limited success of such immunological applications as well as, we explored and measured both in nine cases of naturally acquired porcine cysticercosis. For this purpose, 2-Dimensional IgG immunoblots were performed by reacting the sera of each cysticercotic pig with the antigens contained in the vesicular fluid (VF) of their own cysticerci. We found an unexpectedly large diversity among the proteins and antigens contained in each of the nine VFs. Also diverse were the serum IgG antibody responses of the nine pigs, as none of their 2D- immunoblot images exhibited the same number of spots and resembled each other in only 6.3% to 65.3% of their features. So large an individual immunological diversity of the cysticercal antigens and of the infected pigs´ IgG antibody response should be taken into account in the design of immunological tools for diagnosis and prevention of cysticercosis and should also be considered as a possibly significant source of diversity in <i>Taenia solium´s</i> infectiveness and pathogenicity.</p>http://www.biolsci.org/v07p1287.htm |
| spellingShingle | Marcela Esquivel-Velázquez, Carlos Larralde, Julio Morales, Pedro Ostoa-Saloma Protein and Antigen Diversity in the Vesicular Fluid of Taenia Solium Cysticerci Dissected from Naturally Infected Pigs International Journal of Biological Sciences |
| title | Protein and Antigen Diversity in the Vesicular Fluid of Taenia Solium Cysticerci Dissected from Naturally Infected Pigs |
| title_full | Protein and Antigen Diversity in the Vesicular Fluid of Taenia Solium Cysticerci Dissected from Naturally Infected Pigs |
| title_fullStr | Protein and Antigen Diversity in the Vesicular Fluid of Taenia Solium Cysticerci Dissected from Naturally Infected Pigs |
| title_full_unstemmed | Protein and Antigen Diversity in the Vesicular Fluid of Taenia Solium Cysticerci Dissected from Naturally Infected Pigs |
| title_short | Protein and Antigen Diversity in the Vesicular Fluid of Taenia Solium Cysticerci Dissected from Naturally Infected Pigs |
| title_sort | protein and antigen diversity in the vesicular fluid of taenia solium cysticerci dissected from naturally infected pigs |
| url | http://www.biolsci.org/v07p1287.htm |
| work_keys_str_mv | AT marcelaesquivelvel225zquezcarloslarraldejuliomoralespedroostoasaloma proteinandantigendiversityinthevesicularfluidoftaeniasoliumcysticercidissectedfromnaturallyinfectedpigs |