Distractibility, anxiety, irritability, and agitation symptoms are associated with the severity of depressive and manic symptoms in mixed depression
Objective: To explore whether there is an association between distractibility, anxiety, irritability, and agitation (DAIA) symptoms and the severity of depressive and manic symptoms. Methods: Patients with unipolar and bipolar disorder (I and II) and mixed depression were evaluated. DAIA symptoms...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Psiquiatria (ABP)
2022-09-01
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| Series: | Brazilian Journal of Psychiatry |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462022005010203&tlng=en |
| _version_ | 1811181606792069120 |
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| author | Diego Freitas Tavares Paulo Suen Doris Hupfeld Moreno Eduard Vieta Ricardo Alberto Moreno André R. Brunoni |
| author_facet | Diego Freitas Tavares Paulo Suen Doris Hupfeld Moreno Eduard Vieta Ricardo Alberto Moreno André R. Brunoni |
| author_sort | Diego Freitas Tavares |
| collection | DOAJ |
| description | Objective: To explore whether there is an association between distractibility, anxiety, irritability, and agitation (DAIA) symptoms and the severity of depressive and manic symptoms. Methods: Patients with unipolar and bipolar disorder (I and II) and mixed depression were evaluated. DAIA symptoms were assessed using previously described definitions. Results: The full analysis set comprised 100 patients. The severity of depressive symptoms in mixed depression, assessed by Montgomery-Åsberg Depression Rating Scale (MADRS), was significantly associated with the presence of two or more DAIA symptoms in the bipolar sample, influenced mainly by anxiety. The severity of manic symptoms in mixed depression, assessed by Young Mania Rating Scale (YMRS), was significantly associated with the presence of two or more DAIA symptoms in the bipolar sample and three or four DAIA symptoms in the unipolar sample. Conclusion: DAIA symptoms were associated with greater severity of manic symptoms in mixed depression. DAIA symptoms must be evaluated in all patients with mixed features and are associated with the severity of depressive and manic symptoms in mixed depression. Clinical trial registration: ClinicalTrials.gov (NCT04123301). |
| first_indexed | 2024-04-11T09:20:18Z |
| format | Article |
| id | doaj.art-4d0dec781ff549da90d125a291a6b901 |
| institution | Directory Open Access Journal |
| issn | 1809-452X |
| language | English |
| last_indexed | 2024-04-11T09:20:18Z |
| publishDate | 2022-09-01 |
| publisher | Associação Brasileira de Psiquiatria (ABP) |
| record_format | Article |
| series | Brazilian Journal of Psychiatry |
| spelling | doaj.art-4d0dec781ff549da90d125a291a6b9012022-12-22T04:32:13ZengAssociação Brasileira de Psiquiatria (ABP)Brazilian Journal of Psychiatry1809-452X2022-09-0110.47626/1516-4446-2022-2606Distractibility, anxiety, irritability, and agitation symptoms are associated with the severity of depressive and manic symptoms in mixed depressionDiego Freitas Tavareshttps://orcid.org/0000-0002-2265-9805Paulo Suenhttps://orcid.org/0000-0002-7806-6603Doris Hupfeld Morenohttps://orcid.org/0000-0001-7028-1168Eduard Vietahttps://orcid.org/0000-0002-0548-0053Ricardo Alberto Morenohttps://orcid.org/0000-0001-9843-3442André R. Brunonihttps://orcid.org/0000-0002-6310-3571 Objective: To explore whether there is an association between distractibility, anxiety, irritability, and agitation (DAIA) symptoms and the severity of depressive and manic symptoms. Methods: Patients with unipolar and bipolar disorder (I and II) and mixed depression were evaluated. DAIA symptoms were assessed using previously described definitions. Results: The full analysis set comprised 100 patients. The severity of depressive symptoms in mixed depression, assessed by Montgomery-Åsberg Depression Rating Scale (MADRS), was significantly associated with the presence of two or more DAIA symptoms in the bipolar sample, influenced mainly by anxiety. The severity of manic symptoms in mixed depression, assessed by Young Mania Rating Scale (YMRS), was significantly associated with the presence of two or more DAIA symptoms in the bipolar sample and three or four DAIA symptoms in the unipolar sample. Conclusion: DAIA symptoms were associated with greater severity of manic symptoms in mixed depression. DAIA symptoms must be evaluated in all patients with mixed features and are associated with the severity of depressive and manic symptoms in mixed depression. Clinical trial registration: ClinicalTrials.gov (NCT04123301).http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462022005010203&tlng=enMixed depressionmixed statemixed affective statebipolar disordermajor depressive disorder |
| spellingShingle | Diego Freitas Tavares Paulo Suen Doris Hupfeld Moreno Eduard Vieta Ricardo Alberto Moreno André R. Brunoni Distractibility, anxiety, irritability, and agitation symptoms are associated with the severity of depressive and manic symptoms in mixed depression Brazilian Journal of Psychiatry Mixed depression mixed state mixed affective state bipolar disorder major depressive disorder |
| title | Distractibility, anxiety, irritability, and agitation symptoms are associated with the severity of depressive and manic symptoms in mixed depression |
| title_full | Distractibility, anxiety, irritability, and agitation symptoms are associated with the severity of depressive and manic symptoms in mixed depression |
| title_fullStr | Distractibility, anxiety, irritability, and agitation symptoms are associated with the severity of depressive and manic symptoms in mixed depression |
| title_full_unstemmed | Distractibility, anxiety, irritability, and agitation symptoms are associated with the severity of depressive and manic symptoms in mixed depression |
| title_short | Distractibility, anxiety, irritability, and agitation symptoms are associated with the severity of depressive and manic symptoms in mixed depression |
| title_sort | distractibility anxiety irritability and agitation symptoms are associated with the severity of depressive and manic symptoms in mixed depression |
| topic | Mixed depression mixed state mixed affective state bipolar disorder major depressive disorder |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462022005010203&tlng=en |
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