The Effect of Cholesterol on Membrane-Bound Islet Amyloid Polypeptide

The Effect of Cholesterol on Membrane-Bound Islet Amyloid Polypeptide

Islet amyloid polypeptide (IAPP) is a proposed cause of the decreased beta-cell mass in patients with type-II diabetes. The molecular composition of the cell-membrane is important for regulating IAPP cytotoxicity and aggregation. Cholesterol is present at high concentrations in the pancreatic beta-c...

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Bibliographic Details
Main Authors: Mikkel Christensen, Nils A. Berglund, Birgit Schiøtt
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
cholesterol
amylin
simulations
diabetes
aggregation
amyloid
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.657946/full

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