Dynamic Hydrogels Based on Double Imine Connections and Application for Delivery of Fluorouracil
Dynamic hydrogels have been prepared by cross-linking of O-carboxymethyl chitosan (O-CMCS) with reversibly connected imino-PEGylated dynamers. The double imine chitosan/dynamer and dynamer bonds and were used to provide tighter structures and adaptive drug release behaviors of the hydrogels. The str...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2020.00739/full |
| _version_ | 1818240194277539840 |
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| author | Yan Zhang Chi-Yen Pham Rui Yu Eddy Petit Suming Li Mihail Barboiu |
| author_facet | Yan Zhang Chi-Yen Pham Rui Yu Eddy Petit Suming Li Mihail Barboiu |
| author_sort | Yan Zhang |
| collection | DOAJ |
| description | Dynamic hydrogels have been prepared by cross-linking of O-carboxymethyl chitosan (O-CMCS) with reversibly connected imino-PEGylated dynamers. The double imine chitosan/dynamer and dynamer bonds and were used to provide tighter structures and adaptive drug release behaviors of the hydrogels. The structural and physical properties of the resulted hydrogels were examined, showing good thermal stability and higher swelling behaviors (up to 3,000%). When hydrogels with various composition ratios were further applied for delivery of anti-cancer drug fluorouracil (5-FU), high drug encapsulation rates were recorded, up to 97%. The release profile of 5-FU showed fast rate at the beginning, followed by slow increase to the maximum amount within 12 h, demonstrating potential as drug carriers for efficient drug delivery. |
| first_indexed | 2024-12-12T13:09:34Z |
| format | Article |
| id | doaj.art-4d11f72ff2e849fa87df7a59e1063cc9 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-12T13:09:34Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-4d11f72ff2e849fa87df7a59e1063cc92022-12-22T00:23:33ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462020-08-01810.3389/fchem.2020.00739567242Dynamic Hydrogels Based on Double Imine Connections and Application for Delivery of FluorouracilYan Zhang0Chi-Yen Pham1Rui Yu2Eddy Petit3Suming Li4Mihail Barboiu5Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, Wuxi, ChinaDepartment of Pharmacological, Medical and Agronomical Biotechnology, Hanoi University of Science and Technology, Hanoi, VietnamInstitut Europeen des Membranes, UMR5635, University of Montpellier, ENSCM, CNRS, Montpellier, FranceInstitut Europeen des Membranes, UMR5635, University of Montpellier, ENSCM, CNRS, Montpellier, FranceInstitut Europeen des Membranes, UMR5635, University of Montpellier, ENSCM, CNRS, Montpellier, FranceInstitut Europeen des Membranes, UMR5635, University of Montpellier, ENSCM, CNRS, Montpellier, FranceDynamic hydrogels have been prepared by cross-linking of O-carboxymethyl chitosan (O-CMCS) with reversibly connected imino-PEGylated dynamers. The double imine chitosan/dynamer and dynamer bonds and were used to provide tighter structures and adaptive drug release behaviors of the hydrogels. The structural and physical properties of the resulted hydrogels were examined, showing good thermal stability and higher swelling behaviors (up to 3,000%). When hydrogels with various composition ratios were further applied for delivery of anti-cancer drug fluorouracil (5-FU), high drug encapsulation rates were recorded, up to 97%. The release profile of 5-FU showed fast rate at the beginning, followed by slow increase to the maximum amount within 12 h, demonstrating potential as drug carriers for efficient drug delivery.https://www.frontiersin.org/article/10.3389/fchem.2020.00739/fulldynamic covalent chemistrydynamershydrogelsdrug deliveryiminefluorouracil |
| spellingShingle | Yan Zhang Chi-Yen Pham Rui Yu Eddy Petit Suming Li Mihail Barboiu Dynamic Hydrogels Based on Double Imine Connections and Application for Delivery of Fluorouracil Frontiers in Chemistry dynamic covalent chemistry dynamers hydrogels drug delivery imine fluorouracil |
| title | Dynamic Hydrogels Based on Double Imine Connections and Application for Delivery of Fluorouracil |
| title_full | Dynamic Hydrogels Based on Double Imine Connections and Application for Delivery of Fluorouracil |
| title_fullStr | Dynamic Hydrogels Based on Double Imine Connections and Application for Delivery of Fluorouracil |
| title_full_unstemmed | Dynamic Hydrogels Based on Double Imine Connections and Application for Delivery of Fluorouracil |
| title_short | Dynamic Hydrogels Based on Double Imine Connections and Application for Delivery of Fluorouracil |
| title_sort | dynamic hydrogels based on double imine connections and application for delivery of fluorouracil |
| topic | dynamic covalent chemistry dynamers hydrogels drug delivery imine fluorouracil |
| url | https://www.frontiersin.org/article/10.3389/fchem.2020.00739/full |
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