Synthesis and antioxidant properties of some new 5-phenethyl-3-thio-1,2,4-triazoles
Novel derivatives of 4-R-5-phenethyl-4H-1,2,4-triazole-3-thiols were synthesized. The proposed approaches and developed synthetic protocols provided the possibility to design 4-R-5-phenethyl-4H-1,2,4-triazole-3-thiols and their derivatives have been shown. The antioxidant activity of the synthesized...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2021-01-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/53320/download/pdf/ |
| _version_ | 1819062589658759168 |
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| author | Tetiana Ihnatova Andriy Kaplaushenko Yuliia Frolova Evheniy Pryhlo |
| author_facet | Tetiana Ihnatova Andriy Kaplaushenko Yuliia Frolova Evheniy Pryhlo |
| author_sort | Tetiana Ihnatova |
| collection | DOAJ |
| description | Novel derivatives of 4-R-5-phenethyl-4H-1,2,4-triazole-3-thiols were synthesized. The proposed approaches and developed synthetic protocols provided the possibility to design 4-R-5-phenethyl-4H-1,2,4-triazole-3-thiols and their derivatives have been shown. The antioxidant activity of the synthesized compounds was evaluated in vitro by the method of the non-enzymatic initiation of BOD with salts of iron (II). When compared with existing antioxidants, some of our compounds were found to be more potent. |
| first_indexed | 2024-12-21T15:01:11Z |
| format | Article |
| id | doaj.art-4d13a8c613d04449a533ab7aa7577510 |
| institution | Directory Open Access Journal |
| issn | 2603-557X |
| language | English |
| last_indexed | 2024-12-21T15:01:11Z |
| publishDate | 2021-01-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Pharmacia |
| spelling | doaj.art-4d13a8c613d04449a533ab7aa75775102022-12-21T18:59:35ZengPensoft PublishersPharmacia2603-557X2021-01-0168112913310.3897/pharmacia.68.e5332053320Synthesis and antioxidant properties of some new 5-phenethyl-3-thio-1,2,4-triazolesTetiana Ihnatova0Andriy Kaplaushenko1Yuliia Frolova2Evheniy Pryhlo3Zaporizhzhia State Medical UniversityZaporizhzhia State Medical UniversityZaporizhzhia State Medical UniversityZaporizhzhia State Medical UniversityNovel derivatives of 4-R-5-phenethyl-4H-1,2,4-triazole-3-thiols were synthesized. The proposed approaches and developed synthetic protocols provided the possibility to design 4-R-5-phenethyl-4H-1,2,4-triazole-3-thiols and their derivatives have been shown. The antioxidant activity of the synthesized compounds was evaluated in vitro by the method of the non-enzymatic initiation of BOD with salts of iron (II). When compared with existing antioxidants, some of our compounds were found to be more potent.https://pharmacia.pensoft.net/article/53320/download/pdf/ |
| spellingShingle | Tetiana Ihnatova Andriy Kaplaushenko Yuliia Frolova Evheniy Pryhlo Synthesis and antioxidant properties of some new 5-phenethyl-3-thio-1,2,4-triazoles Pharmacia |
| title | Synthesis and antioxidant properties of some new 5-phenethyl-3-thio-1,2,4-triazoles |
| title_full | Synthesis and antioxidant properties of some new 5-phenethyl-3-thio-1,2,4-triazoles |
| title_fullStr | Synthesis and antioxidant properties of some new 5-phenethyl-3-thio-1,2,4-triazoles |
| title_full_unstemmed | Synthesis and antioxidant properties of some new 5-phenethyl-3-thio-1,2,4-triazoles |
| title_short | Synthesis and antioxidant properties of some new 5-phenethyl-3-thio-1,2,4-triazoles |
| title_sort | synthesis and antioxidant properties of some new 5 phenethyl 3 thio 1 2 4 triazoles |
| url | https://pharmacia.pensoft.net/article/53320/download/pdf/ |
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