The Protein Corona as a Confounding Variable of Nanoparticle-Mediated Targeted Vaccine Delivery
Nanocarriers (NC) are very promising tools for cancer immunotherapy. Whereas conventional vaccines are based on the administration of an antigen and an adjuvant in an independent fashion, nanovaccines can facilitate cell-specific co-delivery of antigen and adjuvant. Furthermore, nanovaccines can be...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.01760/full |
| _version_ | 1811329769671753728 |
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| author | Matthias Bros Lutz Nuhn Johanna Simon Johanna Simon Lorna Moll Lorna Moll Volker Mailänder Volker Mailänder Katharina Landfester Stephan Grabbe |
| author_facet | Matthias Bros Lutz Nuhn Johanna Simon Johanna Simon Lorna Moll Lorna Moll Volker Mailänder Volker Mailänder Katharina Landfester Stephan Grabbe |
| author_sort | Matthias Bros |
| collection | DOAJ |
| description | Nanocarriers (NC) are very promising tools for cancer immunotherapy. Whereas conventional vaccines are based on the administration of an antigen and an adjuvant in an independent fashion, nanovaccines can facilitate cell-specific co-delivery of antigen and adjuvant. Furthermore, nanovaccines can be decorated on their surface with molecules that facilitate target-specific antigen delivery to certain antigen-presenting cell types or tumor cells. However, the target cell-specific uptake of nanovaccines is highly dependent on the modifications of the nanocarrier itself. One of these is the formation of a protein corona around NC after in vivo administration, which may potently affect cell-specific targeting and uptake of the NC. Understanding the formation and composition of the protein corona is, therefore, of major importance for the use of nanocarriers in vaccine approaches. This Mini Review will give a short overview of potential non-specific interactions of NC with body fluids or cell surfaces that need to be considered for the design of NC vaccines for immunotherapy of cancer. |
| first_indexed | 2024-04-13T15:49:43Z |
| format | Article |
| id | doaj.art-4d147dd5bd6c4db2a903f75e476bef71 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T15:49:43Z |
| publishDate | 2018-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-4d147dd5bd6c4db2a903f75e476bef712022-12-22T02:40:53ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-08-01910.3389/fimmu.2018.01760365286The Protein Corona as a Confounding Variable of Nanoparticle-Mediated Targeted Vaccine DeliveryMatthias Bros0Lutz Nuhn1Johanna Simon2Johanna Simon3Lorna Moll4Lorna Moll5Volker Mailänder6Volker Mailänder7Katharina Landfester8Stephan Grabbe9Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, GermanyMax Planck Institute for Polymer Research, Mainz, GermanyDepartment of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, GermanyMax Planck Institute for Polymer Research, Mainz, GermanyDepartment of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, GermanyMax Planck Institute for Polymer Research, Mainz, GermanyDepartment of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, GermanyMax Planck Institute for Polymer Research, Mainz, GermanyMax Planck Institute for Polymer Research, Mainz, GermanyDepartment of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, GermanyNanocarriers (NC) are very promising tools for cancer immunotherapy. Whereas conventional vaccines are based on the administration of an antigen and an adjuvant in an independent fashion, nanovaccines can facilitate cell-specific co-delivery of antigen and adjuvant. Furthermore, nanovaccines can be decorated on their surface with molecules that facilitate target-specific antigen delivery to certain antigen-presenting cell types or tumor cells. However, the target cell-specific uptake of nanovaccines is highly dependent on the modifications of the nanocarrier itself. One of these is the formation of a protein corona around NC after in vivo administration, which may potently affect cell-specific targeting and uptake of the NC. Understanding the formation and composition of the protein corona is, therefore, of major importance for the use of nanocarriers in vaccine approaches. This Mini Review will give a short overview of potential non-specific interactions of NC with body fluids or cell surfaces that need to be considered for the design of NC vaccines for immunotherapy of cancer.https://www.frontiersin.org/article/10.3389/fimmu.2018.01760/fullnanocarrierscancer vaccinesimmunotherapyprotein coronacell-specific targeting |
| spellingShingle | Matthias Bros Lutz Nuhn Johanna Simon Johanna Simon Lorna Moll Lorna Moll Volker Mailänder Volker Mailänder Katharina Landfester Stephan Grabbe The Protein Corona as a Confounding Variable of Nanoparticle-Mediated Targeted Vaccine Delivery Frontiers in Immunology nanocarriers cancer vaccines immunotherapy protein corona cell-specific targeting |
| title | The Protein Corona as a Confounding Variable of Nanoparticle-Mediated Targeted Vaccine Delivery |
| title_full | The Protein Corona as a Confounding Variable of Nanoparticle-Mediated Targeted Vaccine Delivery |
| title_fullStr | The Protein Corona as a Confounding Variable of Nanoparticle-Mediated Targeted Vaccine Delivery |
| title_full_unstemmed | The Protein Corona as a Confounding Variable of Nanoparticle-Mediated Targeted Vaccine Delivery |
| title_short | The Protein Corona as a Confounding Variable of Nanoparticle-Mediated Targeted Vaccine Delivery |
| title_sort | protein corona as a confounding variable of nanoparticle mediated targeted vaccine delivery |
| topic | nanocarriers cancer vaccines immunotherapy protein corona cell-specific targeting |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.01760/full |
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