Bioactive Alkaloids from the Sea: A Review
Abstract: In our ongoing search for bioactive substances from marine organisms, novel alkaloids have been isolated. Pinnatoxins and pinnamine, potent shellfish poisons, were purified from the Okinawan bivalve Pinna muricata. Pinnatoxins activate Ca2+ channels. Halichlorine was isolated from the mari...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2004-02-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/2/1/39/ |
| _version_ | 1811185212826058752 |
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| author | Makoto Kuramoto Hirokazu Arimoto Daisuke Uemura |
| author_facet | Makoto Kuramoto Hirokazu Arimoto Daisuke Uemura |
| author_sort | Makoto Kuramoto |
| collection | DOAJ |
| description | Abstract: In our ongoing search for bioactive substances from marine organisms, novel alkaloids have been isolated. Pinnatoxins and pinnamine, potent shellfish poisons, were purified from the Okinawan bivalve Pinna muricata. Pinnatoxins activate Ca2+ channels. Halichlorine was isolated from the marine sponge Halichondria okadai. This compound inhibits the induction of VCAM-1. Drugs that block VCAM-1 may be useful for treating coronary artery diseases, angina, and noncardiovascular inflammatory diseases. Pinnaic acids, which are cPLA2 inhibitors, were also obtained from P. muricata. Interestingly, the structures of pinnaic acids are closely related to that of halichlorine. Norzoanthamine hydrochloride, isolated from the colonial zoanthid Zoanthus sp., suppresses decreases in bone weight and strength in ovariectomized mice, and could be a good candidate for an osteoporotic drug. Ircinamine, purified from the marine sponge Ircinia sp., has a reactive thioester. Aburatubolactams, inhibitors of superoxide anion generation, were isolated from Streptomyces sp. This article covers the bioactive marine alkaloids that have been recently isolated by this research group. |
| first_indexed | 2024-04-11T13:25:32Z |
| format | Article |
| id | doaj.art-4d15d9312c2d47328c1b3c455301175d |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T13:25:32Z |
| publishDate | 2004-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-4d15d9312c2d47328c1b3c455301175d2022-12-22T04:22:05ZengMDPI AGMarine Drugs1660-33972004-02-0121395410.3390/md201039Bioactive Alkaloids from the Sea: A ReviewMakoto KuramotoHirokazu ArimotoDaisuke UemuraAbstract: In our ongoing search for bioactive substances from marine organisms, novel alkaloids have been isolated. Pinnatoxins and pinnamine, potent shellfish poisons, were purified from the Okinawan bivalve Pinna muricata. Pinnatoxins activate Ca2+ channels. Halichlorine was isolated from the marine sponge Halichondria okadai. This compound inhibits the induction of VCAM-1. Drugs that block VCAM-1 may be useful for treating coronary artery diseases, angina, and noncardiovascular inflammatory diseases. Pinnaic acids, which are cPLA2 inhibitors, were also obtained from P. muricata. Interestingly, the structures of pinnaic acids are closely related to that of halichlorine. Norzoanthamine hydrochloride, isolated from the colonial zoanthid Zoanthus sp., suppresses decreases in bone weight and strength in ovariectomized mice, and could be a good candidate for an osteoporotic drug. Ircinamine, purified from the marine sponge Ircinia sp., has a reactive thioester. Aburatubolactams, inhibitors of superoxide anion generation, were isolated from Streptomyces sp. This article covers the bioactive marine alkaloids that have been recently isolated by this research group.http://www.mdpi.com/1660-3397/2/1/39/Ca2+ channelVCAM-1cPLA2anti-OsteoporosisSuperoxide anion |
| spellingShingle | Makoto Kuramoto Hirokazu Arimoto Daisuke Uemura Bioactive Alkaloids from the Sea: A Review Marine Drugs Ca2+ channel VCAM-1 cPLA2 anti-Osteoporosis Superoxide anion |
| title | Bioactive Alkaloids from the Sea: A Review |
| title_full | Bioactive Alkaloids from the Sea: A Review |
| title_fullStr | Bioactive Alkaloids from the Sea: A Review |
| title_full_unstemmed | Bioactive Alkaloids from the Sea: A Review |
| title_short | Bioactive Alkaloids from the Sea: A Review |
| title_sort | bioactive alkaloids from the sea a review |
| topic | Ca2+ channel VCAM-1 cPLA2 anti-Osteoporosis Superoxide anion |
| url | http://www.mdpi.com/1660-3397/2/1/39/ |
| work_keys_str_mv | AT makotokuramoto bioactivealkaloidsfromtheseaareview AT hirokazuarimoto bioactivealkaloidsfromtheseaareview AT daisukeuemura bioactivealkaloidsfromtheseaareview |