Associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general population
We investigated the associations of insulin resistance and β-cell secretion with bone mineral density (BMD) and osteoporosis using data from the National Health and Nutrition Examination Survey. Data on BMD assessed using dual-energy x-ray absorptiometry from 5292 participants were analyzed. Insulin...
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| Format: | Article |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.971960/full |
| _version_ | 1811266399320932352 |
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| author | Yi-Hsiu Fu Wei-Ju Liu Chia-Lin Lee Chia-Lin Lee Chia-Lin Lee Chia-Lin Lee Jun-Sing Wang Jun-Sing Wang Jun-Sing Wang Jun-Sing Wang |
| author_facet | Yi-Hsiu Fu Wei-Ju Liu Chia-Lin Lee Chia-Lin Lee Chia-Lin Lee Chia-Lin Lee Jun-Sing Wang Jun-Sing Wang Jun-Sing Wang Jun-Sing Wang |
| author_sort | Yi-Hsiu Fu |
| collection | DOAJ |
| description | We investigated the associations of insulin resistance and β-cell secretion with bone mineral density (BMD) and osteoporosis using data from the National Health and Nutrition Examination Survey. Data on BMD assessed using dual-energy x-ray absorptiometry from 5292 participants were analyzed. Insulin resistance and β-cell secretion were assessed using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and β-cell function (HOMA-β), respectively. We divided the study population into four groups according to HOMA-IR (<2 vs. ≥ 2) and HOMA-β (<100 vs. ≥ 100). BMD and T score at the lumbar spine, hip joint, and femur were used for analyses. Osteoporosis was defined as a T score ≤ -2.5. Logistic regression analyses were conducted to examine the associations of HOMA-IR and HOMA-β with osteoporosis, and the joint effects of HOMA-IR and HOMA-β on osteoporosis. We found a positive association between HOMA-IR and osteoporosis in participants with a HOMA-β ≥ 100 (OR 8.773, 95% CI 2.160-35.637, p=0.002 at the femoral neck). A negative association between HOMA-β and osteoporosis was noted in those with a HOMA-IR <2 (OR 0.183, 95% CI 0.038-0.882, p=0.034 at the femoral neck). Compared with participants who had HOMA-IR <2 and HOMA-β <100, those with HOMA-IR <2 and HOMA-β ≥ 100 had a lower risk of osteoporosis (OR 0.126, 95% CI 0.020-0.805, p=0.032 at the femoral neck). In conclusion, the association between HOMA-β and BMD/osteoporosis changed as HOMA-IR increased. HOMA-β was negatively associated with osteoporosis when HOMA-IR <2. The association was not significant when HOMA-IR ≥ 2. |
| first_indexed | 2024-04-12T20:42:32Z |
| format | Article |
| id | doaj.art-4d17150dbd444a6fa8ea5709c5c37a7c |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T20:42:32Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-4d17150dbd444a6fa8ea5709c5c37a7c2022-12-22T03:17:22ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-09-011310.3389/fendo.2022.971960971960Associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general populationYi-Hsiu Fu0Wei-Ju Liu1Chia-Lin Lee2Chia-Lin Lee3Chia-Lin Lee4Chia-Lin Lee5Jun-Sing Wang6Jun-Sing Wang7Jun-Sing Wang8Jun-Sing Wang9Department of Education, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, TaiwanRong Hsing Research Center for Translational Medicine, Institute of Biomedical Science, National Chung Hsing University, Taichung, TaiwanWe investigated the associations of insulin resistance and β-cell secretion with bone mineral density (BMD) and osteoporosis using data from the National Health and Nutrition Examination Survey. Data on BMD assessed using dual-energy x-ray absorptiometry from 5292 participants were analyzed. Insulin resistance and β-cell secretion were assessed using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and β-cell function (HOMA-β), respectively. We divided the study population into four groups according to HOMA-IR (<2 vs. ≥ 2) and HOMA-β (<100 vs. ≥ 100). BMD and T score at the lumbar spine, hip joint, and femur were used for analyses. Osteoporosis was defined as a T score ≤ -2.5. Logistic regression analyses were conducted to examine the associations of HOMA-IR and HOMA-β with osteoporosis, and the joint effects of HOMA-IR and HOMA-β on osteoporosis. We found a positive association between HOMA-IR and osteoporosis in participants with a HOMA-β ≥ 100 (OR 8.773, 95% CI 2.160-35.637, p=0.002 at the femoral neck). A negative association between HOMA-β and osteoporosis was noted in those with a HOMA-IR <2 (OR 0.183, 95% CI 0.038-0.882, p=0.034 at the femoral neck). Compared with participants who had HOMA-IR <2 and HOMA-β <100, those with HOMA-IR <2 and HOMA-β ≥ 100 had a lower risk of osteoporosis (OR 0.126, 95% CI 0.020-0.805, p=0.032 at the femoral neck). In conclusion, the association between HOMA-β and BMD/osteoporosis changed as HOMA-IR increased. HOMA-β was negatively associated with osteoporosis when HOMA-IR <2. The association was not significant when HOMA-IR ≥ 2.https://www.frontiersin.org/articles/10.3389/fendo.2022.971960/fullbone mineral densityinsulininsulinemiainsulin resistanceosteoporosis |
| spellingShingle | Yi-Hsiu Fu Wei-Ju Liu Chia-Lin Lee Chia-Lin Lee Chia-Lin Lee Chia-Lin Lee Jun-Sing Wang Jun-Sing Wang Jun-Sing Wang Jun-Sing Wang Associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general population Frontiers in Endocrinology bone mineral density insulin insulinemia insulin resistance osteoporosis |
| title | Associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general population |
| title_full | Associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general population |
| title_fullStr | Associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general population |
| title_full_unstemmed | Associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general population |
| title_short | Associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general population |
| title_sort | associations of insulin resistance and insulin secretion with bone mineral density and osteoporosis in a general population |
| topic | bone mineral density insulin insulinemia insulin resistance osteoporosis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.971960/full |
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