Hematinic deficiencies and anemia statuses in anti-gastric parietal cell antibody-positive or all autoantibodies-negative erosive oral lichen planus patients
Approximately 27% of erosive oral lichen planus (EOLP) patients have serum anti-gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA or EOLP itself was a significant factor that caused hematinic deficiencies and anemia statuses in GPCA-positive or autoantibodies-n...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-03-01
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| Series: | Journal of the Formosan Medical Association |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664617308665 |
| _version_ | 1818250800028188672 |
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| author | Julia Yu-Fong Chang Yi-Ping Wang Yu-Hsueh Wu Yu-Xuan Su Yu-Kang Tu Andy Sun |
| author_facet | Julia Yu-Fong Chang Yi-Ping Wang Yu-Hsueh Wu Yu-Xuan Su Yu-Kang Tu Andy Sun |
| author_sort | Julia Yu-Fong Chang |
| collection | DOAJ |
| description | Approximately 27% of erosive oral lichen planus (EOLP) patients have serum anti-gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA or EOLP itself was a significant factor that caused hematinic deficiencies and anemia statuses in GPCA-positive or autoantibodies-negative EOLP patients (GPCA+/EOLP and Abs−/EOLP patients).
Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 41 GPCA+/EOLP patients, 198 Abs−/EOLP patients, and 184 healthy control subjects.
Results: GPCA+/EOLP patients had significantly lower mean Hb, iron (for women only), and vitamin B12 level as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy control subjects. Moreover, GPCA+/EOLP patients had significantly lower serum vitamin B12 level and significantly higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than Abs−/EOLP patients. Furthermore, Abs−/EOLP patients did have significantly lower mean Hb, MCV, iron (for women only), vitamin B12, and folic acid levels as well as significantly greater frequencies of Hb and iron deficiencies than healthy control subjects.
Conclusion: We conclude that serum GPCA is the major factor that causes vitamin B12 deficiency, macrocytosis and pernicious anemia in GPCA+/EOLP patients. Approximately 29–32% GPCA-positive EOLP patients have vitamin B12 deficiency or macrocytosis and about 23–25% vitamin B12 deficiency or macrocytosis EOLP patients have pernicious anemia. ELOP itself does play a significant role in causing anemia and hematinic deficiencies in Abs−/EOLP patients. |
| first_indexed | 2024-12-12T15:58:08Z |
| format | Article |
| id | doaj.art-4d1825ff936d4452a86bbe3e9457e755 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-12T15:58:08Z |
| publishDate | 2018-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-4d1825ff936d4452a86bbe3e9457e7552022-12-22T00:19:27ZengElsevierJournal of the Formosan Medical Association0929-66462018-03-01117322723410.1016/j.jfma.2017.12.009Hematinic deficiencies and anemia statuses in anti-gastric parietal cell antibody-positive or all autoantibodies-negative erosive oral lichen planus patientsJulia Yu-Fong Chang0Yi-Ping Wang1Yu-Hsueh Wu2Yu-Xuan Su3Yu-Kang Tu4Andy Sun5Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, TaiwanInstitute of Epidemiology & Preventive Medicine, Department of Public Health, College of Public Health, National Taiwan University, TaiwanDepartment of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, TaiwanApproximately 27% of erosive oral lichen planus (EOLP) patients have serum anti-gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA or EOLP itself was a significant factor that caused hematinic deficiencies and anemia statuses in GPCA-positive or autoantibodies-negative EOLP patients (GPCA+/EOLP and Abs−/EOLP patients). Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 41 GPCA+/EOLP patients, 198 Abs−/EOLP patients, and 184 healthy control subjects. Results: GPCA+/EOLP patients had significantly lower mean Hb, iron (for women only), and vitamin B12 level as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy control subjects. Moreover, GPCA+/EOLP patients had significantly lower serum vitamin B12 level and significantly higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than Abs−/EOLP patients. Furthermore, Abs−/EOLP patients did have significantly lower mean Hb, MCV, iron (for women only), vitamin B12, and folic acid levels as well as significantly greater frequencies of Hb and iron deficiencies than healthy control subjects. Conclusion: We conclude that serum GPCA is the major factor that causes vitamin B12 deficiency, macrocytosis and pernicious anemia in GPCA+/EOLP patients. Approximately 29–32% GPCA-positive EOLP patients have vitamin B12 deficiency or macrocytosis and about 23–25% vitamin B12 deficiency or macrocytosis EOLP patients have pernicious anemia. ELOP itself does play a significant role in causing anemia and hematinic deficiencies in Abs−/EOLP patients.http://www.sciencedirect.com/science/article/pii/S0929664617308665Anti-gastric parietal cell antibodyOral lichen planusIronMacrocytosisPernicious anemiaVitamin B12 deficiency |
| spellingShingle | Julia Yu-Fong Chang Yi-Ping Wang Yu-Hsueh Wu Yu-Xuan Su Yu-Kang Tu Andy Sun Hematinic deficiencies and anemia statuses in anti-gastric parietal cell antibody-positive or all autoantibodies-negative erosive oral lichen planus patients Journal of the Formosan Medical Association Anti-gastric parietal cell antibody Oral lichen planus Iron Macrocytosis Pernicious anemia Vitamin B12 deficiency |
| title | Hematinic deficiencies and anemia statuses in anti-gastric parietal cell antibody-positive or all autoantibodies-negative erosive oral lichen planus patients |
| title_full | Hematinic deficiencies and anemia statuses in anti-gastric parietal cell antibody-positive or all autoantibodies-negative erosive oral lichen planus patients |
| title_fullStr | Hematinic deficiencies and anemia statuses in anti-gastric parietal cell antibody-positive or all autoantibodies-negative erosive oral lichen planus patients |
| title_full_unstemmed | Hematinic deficiencies and anemia statuses in anti-gastric parietal cell antibody-positive or all autoantibodies-negative erosive oral lichen planus patients |
| title_short | Hematinic deficiencies and anemia statuses in anti-gastric parietal cell antibody-positive or all autoantibodies-negative erosive oral lichen planus patients |
| title_sort | hematinic deficiencies and anemia statuses in anti gastric parietal cell antibody positive or all autoantibodies negative erosive oral lichen planus patients |
| topic | Anti-gastric parietal cell antibody Oral lichen planus Iron Macrocytosis Pernicious anemia Vitamin B12 deficiency |
| url | http://www.sciencedirect.com/science/article/pii/S0929664617308665 |
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