Polish and New Zealand Propolis as Sources of Antioxidant Compounds Inhibit Glioblastoma (T98G, LN-18) Cell Lines and Astrocytoma Cells Derived from Patient
Gliomas, including glioblastoma multiforme and astrocytoma, are common brain cancers in adults. Propolis is a natural product containing many active ingredients. The aim of this study was to compare the chemical composition, total phenolic content and concentration of toxic elements as well as the a...
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MDPI AG
2022-06-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/7/1305 |
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| author | Justyna Moskwa Sylwia Katarzyna Naliwajko Renata Markiewicz-Żukowska Krystyna Joanna Gromkowska-Kępka Jolanta Soroczyńska Anna Puścion-Jakubik Maria Halina Borawska Valery Isidorov Katarzyna Socha |
| author_facet | Justyna Moskwa Sylwia Katarzyna Naliwajko Renata Markiewicz-Żukowska Krystyna Joanna Gromkowska-Kępka Jolanta Soroczyńska Anna Puścion-Jakubik Maria Halina Borawska Valery Isidorov Katarzyna Socha |
| author_sort | Justyna Moskwa |
| collection | DOAJ |
| description | Gliomas, including glioblastoma multiforme and astrocytoma, are common brain cancers in adults. Propolis is a natural product containing many active ingredients. The aim of this study was to compare the chemical composition, total phenolic content and concentration of toxic elements as well as the anticancer potential of Polish (PPE) and New Zealand (Manuka—MPE) propolis extracts on diffuse astrocytoma derived from patient (DASC) and glioblastoma (T98G, LN-18) cell lines. The antioxidants such as flavonoids and chalcones (pinocembrin, pinobanksin, pinobanksin 3-acetate and chrysin) were the main components in both types of propolis. The content of arsenic (As) and lead (Pb) in MPE was higher than PPE. The anti-proliferative study showed strong activity of PPE and MPE propolis on DASC, T98G, and LN-18 cells by apoptosis induction, cell cycle arrest and attenuated migration. These findings suggest that despite their different geographic origins, Polish and New Zealand propolis are sources of antioxidant compounds and show similar activity and a promising anti-glioma potential in in vitro study. However, further in vivo studies are required in order to assess therapeutic potential of propolis. |
| first_indexed | 2024-03-09T10:23:06Z |
| format | Article |
| id | doaj.art-4d184d00b77c40d99cd30e697d8b1e14 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T10:23:06Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-4d184d00b77c40d99cd30e697d8b1e142023-12-01T21:49:49ZengMDPI AGAntioxidants2076-39212022-06-01117130510.3390/antiox11071305Polish and New Zealand Propolis as Sources of Antioxidant Compounds Inhibit Glioblastoma (T98G, LN-18) Cell Lines and Astrocytoma Cells Derived from PatientJustyna Moskwa0Sylwia Katarzyna Naliwajko1Renata Markiewicz-Żukowska2Krystyna Joanna Gromkowska-Kępka3Jolanta Soroczyńska4Anna Puścion-Jakubik5Maria Halina Borawska6Valery Isidorov7Katarzyna Socha8Department of Bromatology, Faculty of Pharmacy with Division of Laboratory Medicine, Medical University of Białystok, Mickiewicza 2D Street, 15-222 Białystok, PolandDepartment of Bromatology, Faculty of Pharmacy with Division of Laboratory Medicine, Medical University of Białystok, Mickiewicza 2D Street, 15-222 Białystok, PolandDepartment of Bromatology, Faculty of Pharmacy with Division of Laboratory Medicine, Medical University of Białystok, Mickiewicza 2D Street, 15-222 Białystok, PolandDepartment of Bromatology, Faculty of Pharmacy with Division of Laboratory Medicine, Medical University of Białystok, Mickiewicza 2D Street, 15-222 Białystok, PolandDepartment of Bromatology, Faculty of Pharmacy with Division of Laboratory Medicine, Medical University of Białystok, Mickiewicza 2D Street, 15-222 Białystok, PolandDepartment of Bromatology, Faculty of Pharmacy with Division of Laboratory Medicine, Medical University of Białystok, Mickiewicza 2D Street, 15-222 Białystok, PolandDepartment of Bromatology, Faculty of Pharmacy with Division of Laboratory Medicine, Medical University of Białystok, Mickiewicza 2D Street, 15-222 Białystok, PolandForest Faculty, Białystok University of Technology, Wiejska 45A Street, 15-351 Białystok, PolandDepartment of Bromatology, Faculty of Pharmacy with Division of Laboratory Medicine, Medical University of Białystok, Mickiewicza 2D Street, 15-222 Białystok, PolandGliomas, including glioblastoma multiforme and astrocytoma, are common brain cancers in adults. Propolis is a natural product containing many active ingredients. The aim of this study was to compare the chemical composition, total phenolic content and concentration of toxic elements as well as the anticancer potential of Polish (PPE) and New Zealand (Manuka—MPE) propolis extracts on diffuse astrocytoma derived from patient (DASC) and glioblastoma (T98G, LN-18) cell lines. The antioxidants such as flavonoids and chalcones (pinocembrin, pinobanksin, pinobanksin 3-acetate and chrysin) were the main components in both types of propolis. The content of arsenic (As) and lead (Pb) in MPE was higher than PPE. The anti-proliferative study showed strong activity of PPE and MPE propolis on DASC, T98G, and LN-18 cells by apoptosis induction, cell cycle arrest and attenuated migration. These findings suggest that despite their different geographic origins, Polish and New Zealand propolis are sources of antioxidant compounds and show similar activity and a promising anti-glioma potential in in vitro study. However, further in vivo studies are required in order to assess therapeutic potential of propolis.https://www.mdpi.com/2076-3921/11/7/1305propolispolyphenols contentglioma cellscancer prevention and treatment |
| spellingShingle | Justyna Moskwa Sylwia Katarzyna Naliwajko Renata Markiewicz-Żukowska Krystyna Joanna Gromkowska-Kępka Jolanta Soroczyńska Anna Puścion-Jakubik Maria Halina Borawska Valery Isidorov Katarzyna Socha Polish and New Zealand Propolis as Sources of Antioxidant Compounds Inhibit Glioblastoma (T98G, LN-18) Cell Lines and Astrocytoma Cells Derived from Patient Antioxidants propolis polyphenols content glioma cells cancer prevention and treatment |
| title | Polish and New Zealand Propolis as Sources of Antioxidant Compounds Inhibit Glioblastoma (T98G, LN-18) Cell Lines and Astrocytoma Cells Derived from Patient |
| title_full | Polish and New Zealand Propolis as Sources of Antioxidant Compounds Inhibit Glioblastoma (T98G, LN-18) Cell Lines and Astrocytoma Cells Derived from Patient |
| title_fullStr | Polish and New Zealand Propolis as Sources of Antioxidant Compounds Inhibit Glioblastoma (T98G, LN-18) Cell Lines and Astrocytoma Cells Derived from Patient |
| title_full_unstemmed | Polish and New Zealand Propolis as Sources of Antioxidant Compounds Inhibit Glioblastoma (T98G, LN-18) Cell Lines and Astrocytoma Cells Derived from Patient |
| title_short | Polish and New Zealand Propolis as Sources of Antioxidant Compounds Inhibit Glioblastoma (T98G, LN-18) Cell Lines and Astrocytoma Cells Derived from Patient |
| title_sort | polish and new zealand propolis as sources of antioxidant compounds inhibit glioblastoma t98g ln 18 cell lines and astrocytoma cells derived from patient |
| topic | propolis polyphenols content glioma cells cancer prevention and treatment |
| url | https://www.mdpi.com/2076-3921/11/7/1305 |
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