Effects of Exercise Training during Advanced Maternal Age on the Cognitive Function of Offspring
Advanced maternal age (AMA) denotes an age of ≥35 years during the time of delivery. Maternal metabolism affects the offspring’s physical and neurological development as well as their cognitive function. This study aimed to elucidate the effects of exercise training among old female animals on the c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/10/5517 |
| _version_ | 1797499219516325888 |
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| author | Tae-Woon Kim Sang-Seo Park Hye-Sang Park |
| author_facet | Tae-Woon Kim Sang-Seo Park Hye-Sang Park |
| author_sort | Tae-Woon Kim |
| collection | DOAJ |
| description | Advanced maternal age (AMA) denotes an age of ≥35 years during the time of delivery. Maternal metabolism affects the offspring’s physical and neurological development as well as their cognitive function. This study aimed to elucidate the effects of exercise training among old female animals on the cognitive function, hippocampal neuroplasticity, mitochondrial function, and apoptosis in the offspring. We found that the offspring of mothers with AMA without exercise training had decreased spatial learning and memory, brain-derived neurotrophic factor (BDNF) and postsynaptic density protein 95 (PSD-95) protein levels, neurogenesis, and mitochondrial function, as well as hippocampal cell death. Contrastingly, offspring of mothers with AMA with exercise training showed improved spatial learning, memory, hippocampal neuroplasticity, and mitochondrial function. These findings indicate that despite the AMA, increasing fitness through exercise significantly contributes to a positive prenatal environment for fetuses. The maternal exercises augmented the hippocampal levels of BDNF, which prevents decreased cognitive function in the offspring of mothers with AMA. |
| first_indexed | 2024-03-10T03:44:20Z |
| format | Article |
| id | doaj.art-4d1b6c8ce0df45b5b0c0fe58178d6b79 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:44:20Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4d1b6c8ce0df45b5b0c0fe58178d6b792023-11-23T11:24:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-012310551710.3390/ijms23105517Effects of Exercise Training during Advanced Maternal Age on the Cognitive Function of OffspringTae-Woon Kim0Sang-Seo Park1Hye-Sang Park2Department of Human Health Care, Gyeongsang National University, Jinju 52725, KoreaSchool of Health and Kinesiology, University of Nebraska at Omaha, Omaha, NE 68182, USADepartment of Physiology, College of Medicine, KyungHee University, Seoul 02453, KoreaAdvanced maternal age (AMA) denotes an age of ≥35 years during the time of delivery. Maternal metabolism affects the offspring’s physical and neurological development as well as their cognitive function. This study aimed to elucidate the effects of exercise training among old female animals on the cognitive function, hippocampal neuroplasticity, mitochondrial function, and apoptosis in the offspring. We found that the offspring of mothers with AMA without exercise training had decreased spatial learning and memory, brain-derived neurotrophic factor (BDNF) and postsynaptic density protein 95 (PSD-95) protein levels, neurogenesis, and mitochondrial function, as well as hippocampal cell death. Contrastingly, offspring of mothers with AMA with exercise training showed improved spatial learning, memory, hippocampal neuroplasticity, and mitochondrial function. These findings indicate that despite the AMA, increasing fitness through exercise significantly contributes to a positive prenatal environment for fetuses. The maternal exercises augmented the hippocampal levels of BDNF, which prevents decreased cognitive function in the offspring of mothers with AMA.https://www.mdpi.com/1422-0067/23/10/5517advanced maternal ageoffspringexercisecognitive functionhippocampusneuroplasticity |
| spellingShingle | Tae-Woon Kim Sang-Seo Park Hye-Sang Park Effects of Exercise Training during Advanced Maternal Age on the Cognitive Function of Offspring International Journal of Molecular Sciences advanced maternal age offspring exercise cognitive function hippocampus neuroplasticity |
| title | Effects of Exercise Training during Advanced Maternal Age on the Cognitive Function of Offspring |
| title_full | Effects of Exercise Training during Advanced Maternal Age on the Cognitive Function of Offspring |
| title_fullStr | Effects of Exercise Training during Advanced Maternal Age on the Cognitive Function of Offspring |
| title_full_unstemmed | Effects of Exercise Training during Advanced Maternal Age on the Cognitive Function of Offspring |
| title_short | Effects of Exercise Training during Advanced Maternal Age on the Cognitive Function of Offspring |
| title_sort | effects of exercise training during advanced maternal age on the cognitive function of offspring |
| topic | advanced maternal age offspring exercise cognitive function hippocampus neuroplasticity |
| url | https://www.mdpi.com/1422-0067/23/10/5517 |
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