Methylation of p15INK4b and expression of ANRIL on chromosome 9p21 are associated with coronary artery disease.

Methylation of p15INK4b and expression of ANRIL on chromosome 9p21 are associated with coronary artery disease.

BACKGROUND: Genome-wide association studies have identified that multiple single nucleiotide polymorphisms on chromosome 9p21 are tightly associated with coronary artery disease (CAD). However, the mechanism linking this risk locus to CAD remains unclear. METHODOLOGY/PRINCIPAL FINDINGS: The methylat...

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Bibliographic Details
Main Authors: Jianhui Zhuang, Wenhui Peng, Hailing Li, Wei Wang, Yidong Wei, Weiming Li, Yawei Xu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3473029?pdf=render

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