Computational Analysis of Coronary Blood Flow: The Role of Asynchronous Pacing and Arrhythmias
In this work we present a one-dimensional (1D) mathematical model of the coronary circulation and use it to study the effects of arrhythmias on coronary blood flow (CBF). Hydrodynamical models are rarely used to study arrhythmias’ effects on CBF. Our model accounts for action potential duration, whi...
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| Format: | Article |
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MDPI AG
2020-07-01
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| Series: | Mathematics |
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| Online Access: | https://www.mdpi.com/2227-7390/8/8/1205 |
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| author | Timur Gamilov Philipp Kopylov Maria Serova Roman Syunyaev Andrey Pikunov Sofya Belova Fuyou Liang Jordi Alastruey Sergey Simakov |
| author_facet | Timur Gamilov Philipp Kopylov Maria Serova Roman Syunyaev Andrey Pikunov Sofya Belova Fuyou Liang Jordi Alastruey Sergey Simakov |
| author_sort | Timur Gamilov |
| collection | DOAJ |
| description | In this work we present a one-dimensional (1D) mathematical model of the coronary circulation and use it to study the effects of arrhythmias on coronary blood flow (CBF). Hydrodynamical models are rarely used to study arrhythmias’ effects on CBF. Our model accounts for action potential duration, which updates the length of systole depending on the heart rate. It also includes dependency of stroke volume on heart rate, which is based on clinical data. We apply the new methodology to the computational evaluation of CBF during interventricular asynchrony due to cardiac pacing and some types of arrhythmias including tachycardia, bradycardia, long QT syndrome and premature ventricular contraction (bigeminy, trigeminy, quadrigeminy). We find that CBF can be significantly affected by arrhythmias. CBF at rest (60 bpm) is 26% lower in LCA and 22% lower in RCA for long QT syndrome. During bigeminy, trigeminy and quadrigeminy, respectively, CBF decreases by 28%, 19% and 14% with respect to a healthy case. |
| first_indexed | 2024-03-10T18:17:49Z |
| format | Article |
| id | doaj.art-4d22d85b01b543d5b070093bf8cc5e31 |
| institution | Directory Open Access Journal |
| issn | 2227-7390 |
| language | English |
| last_indexed | 2024-03-10T18:17:49Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Mathematics |
| spelling | doaj.art-4d22d85b01b543d5b070093bf8cc5e312023-11-20T07:31:44ZengMDPI AGMathematics2227-73902020-07-0188120510.3390/math8081205Computational Analysis of Coronary Blood Flow: The Role of Asynchronous Pacing and ArrhythmiasTimur Gamilov0Philipp Kopylov1Maria Serova2Roman Syunyaev3Andrey Pikunov4Sofya Belova5Fuyou Liang6Jordi Alastruey7Sergey Simakov8Moscow Institute of Physics and Technology, 141701 Dolgoprudny, RussiaInstitute of Personalized Medicine, Sechenov University, 119992 Moscow, RussiaInstitute of Personalized Medicine, Sechenov University, 119992 Moscow, RussiaMoscow Institute of Physics and Technology, 141701 Dolgoprudny, RussiaMoscow Institute of Physics and Technology, 141701 Dolgoprudny, RussiaInstitute of Psychology of Russian Academy of Sciences, 129366 Moscow, RussiaInstitute of Personalized Medicine, Sechenov University, 119992 Moscow, RussiaInstitute of Personalized Medicine, Sechenov University, 119992 Moscow, RussiaMoscow Institute of Physics and Technology, 141701 Dolgoprudny, RussiaIn this work we present a one-dimensional (1D) mathematical model of the coronary circulation and use it to study the effects of arrhythmias on coronary blood flow (CBF). Hydrodynamical models are rarely used to study arrhythmias’ effects on CBF. Our model accounts for action potential duration, which updates the length of systole depending on the heart rate. It also includes dependency of stroke volume on heart rate, which is based on clinical data. We apply the new methodology to the computational evaluation of CBF during interventricular asynchrony due to cardiac pacing and some types of arrhythmias including tachycardia, bradycardia, long QT syndrome and premature ventricular contraction (bigeminy, trigeminy, quadrigeminy). We find that CBF can be significantly affected by arrhythmias. CBF at rest (60 bpm) is 26% lower in LCA and 22% lower in RCA for long QT syndrome. During bigeminy, trigeminy and quadrigeminy, respectively, CBF decreases by 28%, 19% and 14% with respect to a healthy case.https://www.mdpi.com/2227-7390/8/8/12051D haemodynamicssystole variationscoronary circulationcardiac pacingtachycardiabradycardia |
| spellingShingle | Timur Gamilov Philipp Kopylov Maria Serova Roman Syunyaev Andrey Pikunov Sofya Belova Fuyou Liang Jordi Alastruey Sergey Simakov Computational Analysis of Coronary Blood Flow: The Role of Asynchronous Pacing and Arrhythmias Mathematics 1D haemodynamics systole variations coronary circulation cardiac pacing tachycardia bradycardia |
| title | Computational Analysis of Coronary Blood Flow: The Role of Asynchronous Pacing and Arrhythmias |
| title_full | Computational Analysis of Coronary Blood Flow: The Role of Asynchronous Pacing and Arrhythmias |
| title_fullStr | Computational Analysis of Coronary Blood Flow: The Role of Asynchronous Pacing and Arrhythmias |
| title_full_unstemmed | Computational Analysis of Coronary Blood Flow: The Role of Asynchronous Pacing and Arrhythmias |
| title_short | Computational Analysis of Coronary Blood Flow: The Role of Asynchronous Pacing and Arrhythmias |
| title_sort | computational analysis of coronary blood flow the role of asynchronous pacing and arrhythmias |
| topic | 1D haemodynamics systole variations coronary circulation cardiac pacing tachycardia bradycardia |
| url | https://www.mdpi.com/2227-7390/8/8/1205 |
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