Multiple-Hit Hypothesis in Parkinson’s Disease: LRRK2 and Inflammation

Multiple-Hit Hypothesis in Parkinson’s Disease: LRRK2 and Inflammation

The multiple hit hypothesis for Parkinson’s disease (PD) suggests that an interaction between multiple (genetic and/or environmental) risk factors is needed to trigger the pathology. Leucine-Rich Repeat Kinase 2 (LRRK2) is an interesting protein to study in this context and is the focus of this revi...

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Bibliographic Details
Main Authors: Diego Cabezudo, Veerle Baekelandt, Evy Lobbestael
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Neuroscience
Subjects:
LRRK2
Parkinson’s disease
inflammation
neuroinflammation
IBD
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00376/full

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