Evaluation of the effect of orexin-1 receptors in the nucleus accumbens shell on cost-benefit decision making in male rats
Background: Cost-benefit decision-making is a one of the decision-making models in which the animal achieves a final benefit (reward) by evaluating the cost (effort or delay). The role of different brain regions such as nucleus accumbens in this process has been proven. Orexin is a neuropeptide expr...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Kashan University of Medical Sciences and Health Services
2019-06-01
|
| Series: | Fiyz̤ |
| Subjects: | |
| Online Access: | http://feyz.kaums.ac.ir/article-1-3800-en.html |
| _version_ | 1817993614119141376 |
|---|---|
| author | Saeedeh Nasrollahi Sara Karimi Alireza Abed Gholamali Hamidi |
| author_facet | Saeedeh Nasrollahi Sara Karimi Alireza Abed Gholamali Hamidi |
| author_sort | Saeedeh Nasrollahi |
| collection | DOAJ |
| description | Background: Cost-benefit decision-making is a one of the decision-making models in which the animal achieves a final benefit (reward) by evaluating the cost (effort or delay). The role of different brain regions such as nucleus accumbens in this process has been proven. Orexin is a neuropeptide expressed exclusively by lateral hypothalamus area neurons and orexin-producing neurons project their axons throughout the brain such as nucleus accumbens. The nucleus accumbens is a region of neural system that serves effort-based decision-making and orexin 1 receptor is distributed extensively throughout nucleus accumbens. Different physiological acts for erixin have been shown including cognitive actions and rewards. Since there is limited knowledge about this subject, this study aimed to examine the effect of orexin 1 receptor in the nucleus accumbens shell on effort-based decision-making.
Materials and Methods: In this study, T-maze was used to investigate cost-benefit decision-making based on effort, and the effect of SB334867 (30, 100, 300 nM/0.5µlDMSO), as selective orexin 1 receptor antagonist, within the nucleus accumbens shell was examined.
Results: SB334867 300 nM/0.5µl DMSO (injection in the shell of nucleus accumbens) significantly decreased the percentage of high reward choice (P<0.01) than the control group.
Conclusion: SB334867 affects the animal's preference for crossing the barrier and achieving more rewards, and the animal chooses to lower reward, without any effort. |
| first_indexed | 2024-04-14T01:42:11Z |
| format | Article |
| id | doaj.art-4d26c4dfc9534a278eec898cdecaba90 |
| institution | Directory Open Access Journal |
| issn | 2008-9821 2008-9821 |
| language | fas |
| last_indexed | 2024-04-14T01:42:11Z |
| publishDate | 2019-06-01 |
| publisher | Kashan University of Medical Sciences and Health Services |
| record_format | Article |
| series | Fiyz̤ |
| spelling | doaj.art-4d26c4dfc9534a278eec898cdecaba902022-12-22T02:19:41ZfasKashan University of Medical Sciences and Health ServicesFiyz̤2008-98212008-98212019-06-01232143152Evaluation of the effect of orexin-1 receptors in the nucleus accumbens shell on cost-benefit decision making in male ratsSaeedeh Nasrollahi0 Sara Karimi1 Alireza Abed 2 Gholamali Hamidi 3Student Research Committee, Kashan University of Medical Sciences, Kashan, I.R. Iran.Student Research Committee, Kashan University of Medical Sciences, Kashan, I.R. Iran.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. IranPhysiology Research Center, Kashan University of Medical Sciences, Kashan, I.R. Iran.Background: Cost-benefit decision-making is a one of the decision-making models in which the animal achieves a final benefit (reward) by evaluating the cost (effort or delay). The role of different brain regions such as nucleus accumbens in this process has been proven. Orexin is a neuropeptide expressed exclusively by lateral hypothalamus area neurons and orexin-producing neurons project their axons throughout the brain such as nucleus accumbens. The nucleus accumbens is a region of neural system that serves effort-based decision-making and orexin 1 receptor is distributed extensively throughout nucleus accumbens. Different physiological acts for erixin have been shown including cognitive actions and rewards. Since there is limited knowledge about this subject, this study aimed to examine the effect of orexin 1 receptor in the nucleus accumbens shell on effort-based decision-making. Materials and Methods: In this study, T-maze was used to investigate cost-benefit decision-making based on effort, and the effect of SB334867 (30, 100, 300 nM/0.5µlDMSO), as selective orexin 1 receptor antagonist, within the nucleus accumbens shell was examined. Results: SB334867 300 nM/0.5µl DMSO (injection in the shell of nucleus accumbens) significantly decreased the percentage of high reward choice (P<0.01) than the control group. Conclusion: SB334867 affects the animal's preference for crossing the barrier and achieving more rewards, and the animal chooses to lower reward, without any effort.http://feyz.kaums.ac.ir/article-1-3800-en.htmlCost-benefit decision-makingOrexin |
| spellingShingle | Saeedeh Nasrollahi Sara Karimi Alireza Abed Gholamali Hamidi Evaluation of the effect of orexin-1 receptors in the nucleus accumbens shell on cost-benefit decision making in male rats Fiyz̤ Cost-benefit decision-making Orexin |
| title | Evaluation of the effect of orexin-1 receptors in the nucleus accumbens shell on cost-benefit decision making in male rats |
| title_full | Evaluation of the effect of orexin-1 receptors in the nucleus accumbens shell on cost-benefit decision making in male rats |
| title_fullStr | Evaluation of the effect of orexin-1 receptors in the nucleus accumbens shell on cost-benefit decision making in male rats |
| title_full_unstemmed | Evaluation of the effect of orexin-1 receptors in the nucleus accumbens shell on cost-benefit decision making in male rats |
| title_short | Evaluation of the effect of orexin-1 receptors in the nucleus accumbens shell on cost-benefit decision making in male rats |
| title_sort | evaluation of the effect of orexin 1 receptors in the nucleus accumbens shell on cost benefit decision making in male rats |
| topic | Cost-benefit decision-making Orexin |
| url | http://feyz.kaums.ac.ir/article-1-3800-en.html |
| work_keys_str_mv | AT saeedehnasrollahi evaluationoftheeffectoforexin1receptorsinthenucleusaccumbensshelloncostbenefitdecisionmakinginmalerats AT sarakarimi evaluationoftheeffectoforexin1receptorsinthenucleusaccumbensshelloncostbenefitdecisionmakinginmalerats AT alirezaabed evaluationoftheeffectoforexin1receptorsinthenucleusaccumbensshelloncostbenefitdecisionmakinginmalerats AT gholamalihamidi evaluationoftheeffectoforexin1receptorsinthenucleusaccumbensshelloncostbenefitdecisionmakinginmalerats |