Pancreatic stellate cells in pancreatic cancer: as potential targets for future therapy
Pancreatic cancer is a strongly malignant gastrointestinal carcinoma characterized by late detection, high mortality rates, poor patient prognosis and lack of effective treatments. Consequently, there is an urgent need to identify novel therapeutic strategies for this disease. Pancreatic stellate ce...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1185093/full |
| _version_ | 1797799757688602624 |
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| author | Zhengfeng Wang Ru He Shi Dong Wence Zhou Wence Zhou |
| author_facet | Zhengfeng Wang Ru He Shi Dong Wence Zhou Wence Zhou |
| author_sort | Zhengfeng Wang |
| collection | DOAJ |
| description | Pancreatic cancer is a strongly malignant gastrointestinal carcinoma characterized by late detection, high mortality rates, poor patient prognosis and lack of effective treatments. Consequently, there is an urgent need to identify novel therapeutic strategies for this disease. Pancreatic stellate cells, which constitute a significant component of the mesenchymal cellular layer within the pancreatic tumor microenvironment, play a pivotal role in modulating this environment through their interactions with pancreatic cancer cells. This paper reviews the mechanisms by which pancreatic stellate cells inhibit antitumor immune responses and promote cancer progression. We also discuss preclinical studies focusing on these cells, with the goal of providing some theoretical references for the development of new therapeutic approaches for pancreatic cancer. |
| first_indexed | 2024-03-13T04:23:44Z |
| format | Article |
| id | doaj.art-4d27350cf4e44791adb23e23e857be46 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T04:23:44Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4d27350cf4e44791adb23e23e857be462023-06-20T08:23:05ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-06-011310.3389/fonc.2023.11850931185093Pancreatic stellate cells in pancreatic cancer: as potential targets for future therapyZhengfeng Wang0Ru He1Shi Dong2Wence Zhou3Wence Zhou4Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, ChinaThe Second School of Clinical Medicine, Lanzhou University Medical College, Lanzhou, ChinaThe Second School of Clinical Medicine, Lanzhou University Medical College, Lanzhou, ChinaThe Second School of Clinical Medicine, Lanzhou University Medical College, Lanzhou, ChinaDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, ChinaPancreatic cancer is a strongly malignant gastrointestinal carcinoma characterized by late detection, high mortality rates, poor patient prognosis and lack of effective treatments. Consequently, there is an urgent need to identify novel therapeutic strategies for this disease. Pancreatic stellate cells, which constitute a significant component of the mesenchymal cellular layer within the pancreatic tumor microenvironment, play a pivotal role in modulating this environment through their interactions with pancreatic cancer cells. This paper reviews the mechanisms by which pancreatic stellate cells inhibit antitumor immune responses and promote cancer progression. We also discuss preclinical studies focusing on these cells, with the goal of providing some theoretical references for the development of new therapeutic approaches for pancreatic cancer.https://www.frontiersin.org/articles/10.3389/fonc.2023.1185093/fullpancreatic cancerpancreatic stellate cellsoxidative stressmolecular targetsdrug theraphy |
| spellingShingle | Zhengfeng Wang Ru He Shi Dong Wence Zhou Wence Zhou Pancreatic stellate cells in pancreatic cancer: as potential targets for future therapy Frontiers in Oncology pancreatic cancer pancreatic stellate cells oxidative stress molecular targets drug theraphy |
| title | Pancreatic stellate cells in pancreatic cancer: as potential targets for future therapy |
| title_full | Pancreatic stellate cells in pancreatic cancer: as potential targets for future therapy |
| title_fullStr | Pancreatic stellate cells in pancreatic cancer: as potential targets for future therapy |
| title_full_unstemmed | Pancreatic stellate cells in pancreatic cancer: as potential targets for future therapy |
| title_short | Pancreatic stellate cells in pancreatic cancer: as potential targets for future therapy |
| title_sort | pancreatic stellate cells in pancreatic cancer as potential targets for future therapy |
| topic | pancreatic cancer pancreatic stellate cells oxidative stress molecular targets drug theraphy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1185093/full |
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