The Use of Volumetric Chest Computed Tomography in Determination of Chronic Obstructive Pulmonary Disease Phenotypes
Background: Chronic Obstructive Pulmonary Disease (COPD) represents one of the major causes of chronic morbidity where, airflow limitation is caused by a mixture of small airways disease and parenchyma destruction. Objective: to correlate the clinical characteristics of patients with COPD with imagi...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
College of Medicine University of Baghdad
2014-04-01
|
| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/419 |
| _version_ | 1827392816667426816 |
|---|---|
| author | Atheer A. Fadhil Mustafa Nema Shaymaa A. Abdalrazak |
| author_facet | Atheer A. Fadhil Mustafa Nema Shaymaa A. Abdalrazak |
| author_sort | Atheer A. Fadhil |
| collection | DOAJ |
| description | Background: Chronic Obstructive Pulmonary Disease (COPD) represents one of the major causes of chronic morbidity where, airflow limitation is caused by a mixture of small airways disease and parenchyma destruction.
Objective: to correlate the clinical characteristics of patients with COPD with imaging classification into phenotypes.
Patients and Methods: Thirty patients with stable COPD were examined by chest CT. Bronchial wall thickness is evaluated by measuring the wall area percentage by identifying the trunk of the apical bronchus of the right upper lobe, while the extent of emphysema was assessed using the percentage of lung voxels with X-ray attenuation values less than -950 HU {automatically calculated by special software}.
Results: Three phenotypes were found: A phenotype (airway-predominant) , 66.6% of total, E phenotype (emphysema predominant), 20% of total and M phenotype (mixed), 13.3% of total.
Conclusions: Using volumetric chest CT in patients with chronic obstructive pulmonary diseases determine three disease patterns. Airway predominant disease which correlate to patients who have clinical & spirometric pattern of chronic bronchitis rather than emphysema. Emphysema predominant on CT correlated with patients with clinical findings of lung hyperinflation rather than bronchial inflammation. Patients with mixed CT findings combined of both previously mentioned types found to be correlated with those with overlapped clinical patterns of both chronic bronchitis & emphysema. |
| first_indexed | 2024-03-08T17:38:50Z |
| format | Article |
| id | doaj.art-4d2792d86b6e4f1a8e686ce5bcf5b0bc |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:38:50Z |
| publishDate | 2014-04-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-4d2792d86b6e4f1a8e686ce5bcf5b0bc2024-01-02T11:30:20ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572014-04-0156110.32007/jfacmedbagdad.v120-24%The Use of Volumetric Chest Computed Tomography in Determination of Chronic Obstructive Pulmonary Disease PhenotypesAtheer A. Fadhil0Mustafa Nema1Shaymaa A. Abdalrazak2Dept. of Radiology, Baghdad Teaching Hospital, Medical City.Dept. of Medicine, College of Medicine, University of Baghdad.Dept. of Radiology, Baghdad Teaching Hospital, Medical City.Background: Chronic Obstructive Pulmonary Disease (COPD) represents one of the major causes of chronic morbidity where, airflow limitation is caused by a mixture of small airways disease and parenchyma destruction. Objective: to correlate the clinical characteristics of patients with COPD with imaging classification into phenotypes. Patients and Methods: Thirty patients with stable COPD were examined by chest CT. Bronchial wall thickness is evaluated by measuring the wall area percentage by identifying the trunk of the apical bronchus of the right upper lobe, while the extent of emphysema was assessed using the percentage of lung voxels with X-ray attenuation values less than -950 HU {automatically calculated by special software}. Results: Three phenotypes were found: A phenotype (airway-predominant) , 66.6% of total, E phenotype (emphysema predominant), 20% of total and M phenotype (mixed), 13.3% of total. Conclusions: Using volumetric chest CT in patients with chronic obstructive pulmonary diseases determine three disease patterns. Airway predominant disease which correlate to patients who have clinical & spirometric pattern of chronic bronchitis rather than emphysema. Emphysema predominant on CT correlated with patients with clinical findings of lung hyperinflation rather than bronchial inflammation. Patients with mixed CT findings combined of both previously mentioned types found to be correlated with those with overlapped clinical patterns of both chronic bronchitis & emphysema.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/419chronic obstructive airway disease (COPD), volumetric chest CT, COPD phenotypes. |
| spellingShingle | Atheer A. Fadhil Mustafa Nema Shaymaa A. Abdalrazak The Use of Volumetric Chest Computed Tomography in Determination of Chronic Obstructive Pulmonary Disease Phenotypes مجلة كلية الطب chronic obstructive airway disease (COPD), volumetric chest CT, COPD phenotypes. |
| title | The Use of Volumetric Chest Computed Tomography in Determination of Chronic Obstructive Pulmonary Disease Phenotypes |
| title_full | The Use of Volumetric Chest Computed Tomography in Determination of Chronic Obstructive Pulmonary Disease Phenotypes |
| title_fullStr | The Use of Volumetric Chest Computed Tomography in Determination of Chronic Obstructive Pulmonary Disease Phenotypes |
| title_full_unstemmed | The Use of Volumetric Chest Computed Tomography in Determination of Chronic Obstructive Pulmonary Disease Phenotypes |
| title_short | The Use of Volumetric Chest Computed Tomography in Determination of Chronic Obstructive Pulmonary Disease Phenotypes |
| title_sort | use of volumetric chest computed tomography in determination of chronic obstructive pulmonary disease phenotypes |
| topic | chronic obstructive airway disease (COPD), volumetric chest CT, COPD phenotypes. |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/419 |
| work_keys_str_mv | AT atheerafadhil theuseofvolumetricchestcomputedtomographyindeterminationofchronicobstructivepulmonarydiseasephenotypes AT mustafanema theuseofvolumetricchestcomputedtomographyindeterminationofchronicobstructivepulmonarydiseasephenotypes AT shaymaaaabdalrazak theuseofvolumetricchestcomputedtomographyindeterminationofchronicobstructivepulmonarydiseasephenotypes AT atheerafadhil useofvolumetricchestcomputedtomographyindeterminationofchronicobstructivepulmonarydiseasephenotypes AT mustafanema useofvolumetricchestcomputedtomographyindeterminationofchronicobstructivepulmonarydiseasephenotypes AT shaymaaaabdalrazak useofvolumetricchestcomputedtomographyindeterminationofchronicobstructivepulmonarydiseasephenotypes |